Detalhe da pesquisa
1.
Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay.
Drug Metab Dispos
; 45(6): 604-611, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28325716
2.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28818462
3.
Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.
Drug Metab Dispos
; 44(8): 1332-1340, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961241
4.
Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
Antimicrob Agents Chemother
; 58(6): 3485-95, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733465
5.
Application of an in vitro OAT assay in drug design and optimization of renal clearance.
Xenobiotica
; 44(7): 657-65, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24417751
6.
Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis.
Nucleic Acids Res
; 40(22): 11499-509, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23066095
7.
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Drug Metab Dispos
; 38(1): 16-24, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19833845
8.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28234467
9.
Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
J Pharm Sci
; 104(9): 2813-23, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631585
10.
Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
Biopharm Drug Dispos
; 29(5): 270-9, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18548464
11.
Biaryl isoxazolinone antibacterial agents.
Bioorg Med Chem Lett
; 15(11): 2728-33, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15869878
12.
Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity.
Bioconjug Chem
; 13(4): 855-69, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12121142