RESUMO
We have considered the opportunity to add some remarks about the management and treatment of bleeding due to stomal varices, after reading the article written by López-Couceiro et al, in which our previous article is referred.
Assuntos
Hipertensão Portal , Varizes , Hemorragia , Humanos , Cirrose HepáticaRESUMO
BACKGROUND AND AIM: Capsule endoscopy and double balloon enteroscopy are well-recognized procedures in obscure gastrointestinal bleeding, with many factors that may influence their diagnosis yield. The aim of the present study was to characterize the degree of agreement between both techniques with focus on the type of lesion in a large cohort of patients at a referral center. MATERIAL AND METHOD: One thousand two hundred and nine capsules were administered in 1,078 patients and 381 enteroscopies were performed in 361 patients with obscure-gastrointestinal bleeding from 2004 to 2014. RESULTS: Both procedures were carried out in 332 patients (mean age: 65.22 +/- 15.41, 183 men) and they have a similar diagnosis yield (70.5% vs. 69.6%, p = 0.9). Overall enteroscopy diagnosis yield was higher within patients with a previous positive capsule endoscopy (79.3% vs. 27.9%, p < 0.001). The degree of agreement was very good for polyps (0.89 [95% CI: 0.78-0.99]), good for vascular lesions (0.66 [95% CI: 0.55-0.77]) and tumors(0.66 [95% CI: 0.55-0.76]) and moderate for ulcers (0.56 [95% CI: 0.46-0.67]). Diverticula (0.39 [95% CI: 0.29-0.5]) achieved a fair agreement. The results of CE and DBE differed in 73 patients (22%). CONCLUSIONS: The present study confirms that although overall diagnostic yield by capsule endoscopy and double-balloon enteroscopy is similar, there are many factors which can modify these values, mainly the type of lesion.
Assuntos
Endoscopia por Cápsula , Enteroscopia de Duplo Balão , Hemorragia Gastrointestinal/etiologia , Adulto , Idoso , Feminino , Hemorragia Gastrointestinal/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Centros de Atenção TerciáriaRESUMO
Wilson's Disease (WD) is an autosomal recessive disorder of copper metabolism resulting in a pathological accumulation of this metal, initially in the liver and later in other organs, mainly brain. Treatment with copper chelating agents and zinc salts results in a depletion of copper deposits and prevents or reverses the clinical manifestations. Copper deficiency may cause haematological and neurological changes, the latter principally being polyneuropathy and myelopathy. We report a patient with WD who developed a myelopathy associated with a deficiency of copper following prolonged treatment with D-penicillamine and zinc salts.
Assuntos
Quelantes/efeitos adversos , Terapia por Quelação/efeitos adversos , Cobre/deficiência , Degeneração Hepatolenticular/complicações , Penicilamina/efeitos adversos , Polineuropatias/induzido quimicamente , Doenças da Medula Espinal/induzido quimicamente , Zinco/efeitos adversos , Ceruloplasmina/análise , Quelantes/uso terapêutico , Cobre/farmacocinética , Cobre/urina , Feminino , Transtornos Neurológicos da Marcha/induzido quimicamente , Degeneração Hepatolenticular/tratamento farmacológico , Degeneração Hepatolenticular/metabolismo , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Exame Neurológico , Penicilamina/uso terapêutico , Polineuropatias/diagnóstico , Reflexo Anormal , Transtornos de Sensação/induzido quimicamente , Doenças da Medula Espinal/diagnóstico , Zinco/farmacocinética , Zinco/uso terapêuticoAssuntos
Hemorragia/etiologia , Hipertensão Portal/complicações , Varizes/complicações , Hemorragia/cirurgia , Humanos , Hipertensão Portal/cirurgia , Cirrose Hepática Alcoólica/complicações , Masculino , Pessoa de Meia-Idade , Derivação Portossistêmica Cirúrgica , Resultado do Tratamento , Varizes/cirurgiaRESUMO
Reactivation of hepatitis B virus infection in patients with resolved infection is rare and is usually associated with immunosuppressive therapy. Morbidity and mortality are high. Some cases of hepatitis B reactivation associated with the use of rituximab have previously been published. We present the case of a patient with B-cell non-Hodgkin lymphoma receiving combination chemotherapy with rituximab who showed hepatitis B reactivation followed by liver failure. The most recent literature on this topic is reviewed and discussed.