Detalhe da pesquisa
1.
The dynamic process of ß(2)-adrenergic receptor activation.
Cell
; 152(3): 532-42, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374348
2.
Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design.
J Comput Aided Mol Des
; 37(11): 519-535, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535171
3.
Correction: Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design.
J Comput Aided Mol Des
; 38(1): 12, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38472529
4.
An improved protocol for amino acid type-selective isotope labeling in insect cells.
J Biomol NMR
; 68(4): 237-247, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28711957
5.
Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.
Anal Chem
; 89(4): 2250-2258, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193005
6.
NMR in drug design.
Arch Biochem Biophys
; 628: 132-147, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28619618
7.
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature
; 463(7277): 108-12, 2010 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20054398
8.
Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research.
J Med Chem
; 67(3): 1701-1733, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290426
9.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg Med Chem Lett
; 23(14): 4107-11, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23747226
10.
Ranking mAb-excipient interactions in biologics formulations by NMR spectroscopy and computational approaches.
MAbs
; 15(1): 2212416, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37218059
11.
NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
J Med Chem
; 49(16): 5013-7, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884313
12.
Atropisomer Control in Macrocyclic Factor VIIa Inhibitors.
J Med Chem
; 59(8): 4007-18, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27015008
13.
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
J Med Chem
; 59(17): 8042-60, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27564532
14.
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.
J Med Chem
; 58(6): 2799-808, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25764119
15.
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1730-52, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24564672
16.
Correction to "Atropisomer Control in Macrocyclic Factor VIIa Inhibitors".
J Med Chem
; 61(8): 3752, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29620363
17.
Alternate HMQC experiments for recording HN and HC-correlation spectra in proteins at high throughput.
J Biomol NMR
; 42(2): 129-37, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18820839
18.
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.
J Med Chem
; 51(19): 6225-9, 2008 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771253
19.
Metabolomic analysis using optimized NMR and statistical methods.
Anal Biochem
; 355(1): 62-70, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16762305
20.
Protein-ligand NOE matching: a high-throughput method for binding pose evaluation that does not require protein NMR resonance assignments.
J Am Chem Soc
; 128(22): 7252-63, 2006 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16734479