Detalhe da pesquisa
1.
Discovery and Development of Cyclic Peptide Proteasome Stimulators.
Chembiochem
; 25(3): e202300671, 2024 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055197
2.
Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.
Tetrahedron
; 1562024 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38618612
3.
20S proteasome hydrolysis of LLVY substrates to determine preferences for moieties in its primed substrate channel.
Bioorg Med Chem Lett
; 85: 129233, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905968
4.
Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers.
Bioorg Med Chem Lett
; 95: 129485, 2023 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714498
5.
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Molecules
; 26(5)2021 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33668938
6.
N-Terminal Targeting of Regulator of G Protein Signaling Protein 2 for F-Box Only Protein 44-Mediated Proteasomal Degradation.
Mol Pharmacol
; 98(6): 677-685, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33008920
7.
Small-Molecule Inhibitors of the Proteasome's Regulatory Particle.
Chembiochem
; 20(14): 1739-1753, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30740849
8.
Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators.
Bioorg Med Chem Lett
; 29(3): 420-423, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587447
9.
High-throughput assay exploiting disorder-to-order conformational switches: application to the proteasomal Rpn10:E6AP complex.
Chem Sci
; 15(11): 4041-4053, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38487241
10.
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.
J Med Chem
; 67(6): 4496-4524, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38488146
11.
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
ACS Med Chem Lett
; 12(5): 791-797, 2021 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34055227
12.
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
J Med Chem
; 64(7): 3940-3955, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780623