Pesquisa | Portal de Pesquisa da BVS

1.

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

Jayavelu, Ashok Kumar; Schnöder, Tina M; Perner, Florian; Herzog, Carolin; Meiler, Arno; Krishnamoorthy, Gurumoorthy; Huber, Nicolas; Mohr, Juliane; Edelmann-Stephan, Bärbel; Austin, Rebecca; Brandt, Sabine; Palandri, Francesca; Schröder, Nicolas; Isermann, Berend; Edlich, Frank; Sinha, Amit U; Ungelenk, Martin; Hübner, Christian A; Zeiser, Robert; Rahmig, Susann; Waskow, Claudia; Coldham, Iain; Ernst, Thomas; Hochhaus, Andreas; Jilg, Stefanie; Jost, Philipp J; Mullally, Ann; Bullinger, Lars; Mertens, Peter R; Lane, Steven W; Mann, Matthias; Heidel, Florian H.

Nature ; 588(7836): 157-163, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33239784

2.

Biology and therapeutic targeting of molecular mechanisms in MPNs.

How, Joan; Garcia, Jacqueline S; Mullally, Ann.

Blood ; 141(16): 1922-1933, 2023 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-36534936

3.

Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms.

Contreras Castillo, Stephania; Montibus, Bertille; Rocha, Azucena; Duke, Will; von Meyenn, Ferdinand; McLornan, Donal; Harrison, Claire; Mullally, Ann; Schulz, Reiner; Oakey, Rebecca J.

Genome Res ; 31(8): 1381-1394, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34244229

4.

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs.

Jutzi, Jonas S; Marneth, Anna E; Ciboddo, Michele; Guerra-Moreno, Angel; Jiménez-Santos, María José; Kosmidou, Anastasia; Dressman, James W; Liang, Hongyan; Hamel, Rebecca; Lozano, Patricia; Rumi, Elisa; Doench, John G; Gotlib, Jason; Krishnan, Anandi; Elf, Shannon; Al-Shahrour, Fátima; Mullally, Ann.

Blood ; 140(11): 1291-1304, 2022 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-35763665

5.

Antibody targeting of mutant calreticulin in myeloproliferative neoplasms.

Kramer, Frederike; Mullally, Ann.

J Cell Mol Med ; 28(5): e17896, 2023 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-37551061

6.

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches.

Vining, Kyle H; Marneth, Anna E; Adu-Berchie, Kwasi; Grolman, Joshua M; Tringides, Christina M; Liu, Yutong; Wong, Waihay J; Pozdnyakova, Olga; Severgnini, Mariano; Stafford, Alexander; Duda, Georg N; Hodi, F Stephen; Mullally, Ann; Wucherpfennig, Kai W; Mooney, David J.

Nat Mater ; 21(8): 939-950, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35817965

7.

Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.

Takei, Hisashi; Coelho-Silva, Juan Luiz; Tavares Leal, Cristina; Queiroz Arantes Rocha, Adriana; Mantello Bianco, Thiago; Welner, Robert S; Mishima, Yuta; Kobayashi, Ikei S; Mullally, Ann; Lima, Keli; Machado-Neto, João Agostinho; Kobayashi, Susumu S; Lobo de Figueiredo-Pontes, Lorena.

Cancer Sci ; 113(2): 597-608, 2022 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-34808021

8.

Mutant calreticulin in myeloproliferative neoplasms.

How, Joan; Hobbs, Gabriela S; Mullally, Ann.

Blood ; 134(25): 2242-2248, 2019 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-31562135

9.

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN.

Elf, Shannon; Abdelfattah, Nouran S; Baral, April J; Beeson, Danielle; Rivera, Jeanne F; Ko, Amy; Florescu, Natalie; Birrane, Gabriel; Chen, Edwin; Mullally, Ann.

Blood ; 131(7): 782-786, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29288169

10.

Two to tango! IL-13 and TGF-ß drive myelofibrosis.

Jutzi, Jonas S; Mullally, Ann.

Blood ; 140(26): 2767-2768, 2022 12 29.

Artigo em Inglês | MEDLINE | ID: mdl-36580345

11.

Myeloproliferative neoplasm stem cells.

Mead, Adam J; Mullally, Ann.

Blood ; 129(12): 1607-1616, 2017 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-28159736

12.

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.

Koppikar, Priya; Bhagwat, Neha; Kilpivaara, Outi; Manshouri, Taghi; Adli, Mazhar; Hricik, Todd; Liu, Fan; Saunders, Lindsay M; Mullally, Ann; Abdel-Wahab, Omar; Leung, Laura; Weinstein, Abby; Marubayashi, Sachie; Goel, Aviva; Gönen, Mithat; Estrov, Zeev; Ebert, Benjamin L; Chiosis, Gabriela; Nimer, Stephen D; Bernstein, Bradley E; Verstovsek, Srdan; Levine, Ross L.

Nature ; 489(7414): 155-9, 2012 Sep 06.

Artigo em Inglês | MEDLINE | ID: mdl-22820254

13.

Both sides now: losses and gains of mutant CALR.

Mullally, Ann.

Blood ; 135(2): 82-83, 2020 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-31917838

14.

Marked hyperferritinemia does not predict for HLH in the adult population.

Schram, Alison M; Campigotto, Federico; Mullally, Ann; Fogerty, Annemarie; Massarotti, Elena; Neuberg, Donna; Berliner, Nancy.

Blood ; 125(10): 1548-52, 2015 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-25573993

15.

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.

Chen, Edwin; Schneider, Rebekka K; Breyfogle, Lawrence J; Rosen, Emily A; Poveromo, Luke; Elf, Shannon; Ko, Amy; Brumme, Kristina; Levine, Ross; Ebert, Benjamin L; Mullally, Ann.

Blood ; 125(2): 327-35, 2015 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-25281607

16.

Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.

Bender, Markus; Giannini, Silvia; Grozovsky, Renata; Jönsson, Terese; Christensen, Hilary; Pluthero, Fred G; Ko, Amy; Mullally, Ann; Kahr, Walter H A; Hoffmeister, Karin M; Falet, Hervé.

Blood ; 125(6): 1014-24, 2015 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-25468568

17.

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Chen, Edwin; Ahn, Jong Sook; Massie, Charlie E; Clynes, David; Godfrey, Anna L; Li, Juan; Park, Hyun Jung; Nangalia, Jyoti; Silber, Yvonne; Mullally, Ann; Gibbons, Richard J; Green, Anthony R.

Proc Natl Acad Sci U S A ; 111(42): 15190-5, 2014 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-25288776

18.

Haemophagocytic lymphohistiocytosis in adults: a multicentre case series over 7 years.

Schram, Alison M; Comstock, Paige; Campo, Meghan; Gorovets, Daniel; Mullally, Ann; Bodio, Kelly; Arnason, Jon; Berliner, Nancy.

Br J Haematol ; 172(3): 412-9, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26537747

19.

Hit the spleen, JAK!

Lane, Steven W; Mullally, Ann.

Blood ; 124(19): 2898-900, 2014 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-25377558

20.

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.

Mullally, Ann; Bruedigam, Claudia; Poveromo, Luke; Heidel, Florian H; Purdon, Amy; Vu, Therese; Austin, Rebecca; Heckl, Dirk; Breyfogle, Lawrence J; Kuhn, Catherine Paine; Kalaitzidis, Demetrios; Armstrong, Scott A; Williams, David A; Hill, Geoff R; Ebert, Benjamin L; Lane, Steven W.

Blood ; 121(18): 3692-702, 2013 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-23487027

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