Detalhe da pesquisa
1.
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry
; 29(29): e202203868, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912255
2.
An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.
Nature
; 539(7630): 593-597, 2016 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27851736
3.
Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches.
J Biol Chem
; 295(22): 7595-7607, 2020 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303637
4.
A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.
Int J Mol Sci
; 22(21)2021 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34768811
5.
Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.
J Am Chem Soc
; 142(37): 15764-15779, 2020 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32811149
6.
Cytochrome P450 1A1 opens up to new substrates.
J Biol Chem
; 293(50): 19211-19212, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552114
7.
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.
Bioorg Med Chem
; 27(8): 1546-1561, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837169
8.
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
J Biol Chem
; 292(4): 1310-1329, 2017 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27932461
9.
Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.
J Biol Chem
; 292(12): 5128-5143, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28053093
10.
Structure and function of the cytochrome P450 peroxygenase enzymes.
Biochem Soc Trans
; 46(1): 183-196, 2018 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432141
11.
Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.
Bioorg Med Chem
; 26(1): 161-176, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29183661
12.
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
Proc Natl Acad Sci U S A
; 112(9): 2847-52, 2015 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25691737
13.
What makes a P450 tick?
Trends Biochem Sci
; 38(3): 140-50, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23356956
14.
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Biochemistry
; 56(11): 1559-1572, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169518
15.
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
Anal Chem
; 89(18): 9976-9983, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28803470
16.
Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.
Biochemistry
; 55(36): 5073-83, 2016 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27546061
17.
Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium.
J Biol Chem
; 289(10): 6535-6550, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24443585
18.
The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
Mol Microbiol
; 93(2): 247-61, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24865947
19.
Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.
Biochem J
; 460(2): 247-59, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24588219
20.
Biological diversity of cytochrome P450 redox partner systems.
Adv Exp Med Biol
; 851: 299-317, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26002740