Detalhe da pesquisa
1.
Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem.
Pediatr Res
; 83(4): 889-896, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29278642
2.
Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial.
Lancet
; 384(9937): 37-44, 2014 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24743000
3.
Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis.
Mol Genet Metab
; 114(2): 281-93, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25257657
4.
Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: safety, pharmacokinetics, and distribution.
Toxicol Appl Pharmacol
; 277(1): 49-57, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24642058
5.
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
J Pharmacol Exp Ther
; 331(2): 470-84, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19704033
6.
An in vivo microdialysis coupled with liquid chromatography/tandem mass spectrometry study of cortisol metabolism in monkey adipose tissue.
Anal Biochem
; 381(2): 214-23, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18638442
7.
Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 873(2): 195-202, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18799366
8.
Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 863(1): 64-73, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255359
9.
Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry.
J Pharm Biomed Anal
; 46(3): 534-42, 2008 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096349
10.
Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function.
Clin Ther
; 39(7): 1360-1370, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28641995
11.
Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization.
J Chromatogr B Analyt Technol Biomed Life Sci
; 843(1): 47-56, 2006 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16815762
12.
Stability studies of vorinostat and its two metabolites in human plasma, serum and urine.
J Pharm Biomed Anal
; 42(5): 556-64, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16824724
13.
Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 817(2): 287-96, 2005 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686997
14.
Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine.
J Chromatogr B Analyt Technol Biomed Life Sci
; 818(2): 241-8, 2005 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15734165
15.
Application of a novel ultra-low elution volume 96-well solid-phase extraction method to the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma.
J Pharm Biomed Anal
; 38(3): 521-7, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15925254
16.
Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults.
Clin Ther
; 37(7): 1555-63, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101174
17.
A prospective population pharmacokinetic analysis of sapropterin dihydrochloride in infants and young children with phenylketonuria.
Clin Pharmacokinet
; 54(2): 195-207, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25338975
18.
Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial.
Clin Ther
; 37(5): 1012-1021.e6, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487082
19.
Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate.
Pharmacol Res Perspect
; 3(1): e00099, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25692017
20.
Simultaneous determination of clofibrate and its active metabolite clofibric acid in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet absorbance detection.
J Chromatogr B Analyt Technol Biomed Life Sci
; 794(2): 343-51, 2003 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12954386