Detalhe da pesquisa
1.
A synthetic antibiotic class overcoming bacterial multidrug resistance.
Nature
; 599(7885): 507-512, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34707295
2.
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Nat Chem Biol
; 2024 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38238495
3.
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.
Nucleic Acids Res
; 51(9): 4536-4554, 2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36951104
4.
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp.
Nucleic Acids Res
; 50(11): 6174-6189, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35699226
5.
[3+2] Dipolar Cycloaddition of a Stabilized Azomethine Ylide and an Electron-Deficient Dipolarophile: Revision of Regioselectivity.
J Org Chem
; 88(3): 1907-1908, 2023 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649386
6.
Proposed Resolution of a Mechanistic Puzzle of Long Duration: Self-Condensation of Cyclopentanone to Form an 11-Carbon Dienoic Acid.
J Org Chem
; 88(11): 7557-7559, 2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37130428
7.
A method for tritiation of iboxamycin permits measurement of its ribosomal binding.
Bioorg Med Chem Lett
; 91: 129364, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37295615
8.
Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens.
Acc Chem Res
; 54(7): 1635-1645, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33691070
9.
A platform for the discovery of new macrolide antibiotics.
Nature
; 533(7603): 338-45, 2016 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27193679
10.
Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate.
J Am Chem Soc
; 143(29): 11019-11025, 2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34264649
11.
A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics.
J Am Chem Soc
; 143(18): 6829-6835, 2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33930268
12.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Nature
; 526(7572): 273-276, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416749
13.
Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars.
Angew Chem Int Ed Engl
; 55(2): 523-7, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26612347
14.
Crystalline guanine adducts of natural and synthetic trioxacarcins suggest a common biological mechanism and reveal a basis for the instability of trioxacarcin A.
Bioorg Med Chem Lett
; 24(18): 4410-4413, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25176186
15.
A multiply convergent platform for the synthesis of trioxacarcins.
Proc Natl Acad Sci U S A
; 108(17): 6709-14, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245350
16.
The evolving role of chemical synthesis in antibacterial drug discovery.
Angew Chem Int Ed Engl
; 53(34): 8840-69, 2014 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24990531
17.
Stereocontrolled synthesis of syn-ß-Hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide.
Angew Chem Int Ed Engl
; 53(18): 4642-7, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24692320
18.
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Science
; 383(6684): 721-726, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359125
19.
(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.
Bioorg Med Chem Lett
; 23(24): 6905-10, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269479
20.
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion.
bioRxiv
; 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37808676