Detalhe da pesquisa
1.
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs.
Proc Natl Acad Sci U S A
; 119(28): e2206113119, 2022 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35867764
2.
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
J Am Chem Soc
; 146(1): 62-67, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38134034
3.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J Chem Inf Model
; 63(9): 2828-2841, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060320
4.
Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 47: 128168, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091041
5.
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 30(13): 127197, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331932
6.
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Bioorg Med Chem Lett
; 30(17): 127367, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738976
7.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
J Chem Inf Model
; 64(3): 1106, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258980
8.
Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.
J Biol Chem
; 291(45): 23428-23439, 2016 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621313
9.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
10.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
11.
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Proc Natl Acad Sci U S A
; 108(13): 5378-83, 2011 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21389266
12.
Determining engagement in services for high-need individuals with serious mental illness.
Adm Policy Ment Health
; 41(5): 588-97, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23636712
13.
Evidence-Based Supported Employment for Individuals With Obsessive-Compulsive Disorder.
Psychiatr Serv
; 75(4): 381-383, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38018152
14.
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Front Physiol
; 14: 1163389, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36950298
15.
Retrospective State Medicaid Claims Analysis of Children and Adults With Obsessive-Compulsive Disorder.
Psychiatr Serv
; 74(11): 1185-1188, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37096356
16.
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nat Commun
; 14(1): 637, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788210
17.
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
bioRxiv
; 2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37808863
18.
Statewide Workforce Development Program to Improve Care for Individuals With Obsessive-Compulsive Disorder.
Psychiatr Serv
; 73(3): 343-345, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34369802
19.
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Front Physiol
; 13: 1013845, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36246105
20.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
J Med Chem
; 65(22): 15208-15226, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36346696