Detalhe da pesquisa
1.
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.
Mol Cell
; 80(3): 437-451.e6, 2020 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33157014
2.
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
EMBO J
; 42(1): e111389, 2023 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36444797
3.
A TGF-ß-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration.
J Cell Sci
; 136(15)2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37439249
4.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Cell
; 141(2): 290-303, 2010 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20381137
5.
The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB.
J Biol Chem
; 298(3): 101744, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35183507
6.
SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
J Biol Chem
; 298(3): 101630, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35085554
7.
p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine.
Cell Struct Funct
; 45(2): 93-105, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32641600
8.
Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site.
J Cell Sci
; 131(3)2018 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29222112
9.
Ubiquitination of Src promotes its secretion via small extracellular vesicles.
Biochem Biophys Res Commun
; 2020 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32085898
10.
Atg5-mediated autophagy controls apoptosis/anoikis via p53/Rb pathway in naked mole-rat fibroblasts.
Biochem Biophys Res Commun
; 528(1): 146-153, 2020 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32451084
11.
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
J Immunol
; 200(11): 3790-3800, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29686050
12.
Src mediates TGF-ß-induced intraocular pressure elevation in glaucoma.
J Cell Physiol
; 234(2): 1730-1744, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30144071
13.
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
J Immunol
; 199(6): 2008-2019, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28768723
14.
Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.
J Am Soc Nephrol
; 27(12): 3653-3665, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27032892
15.
The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.
Mol Cell
; 30(4): 426-36, 2008 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18498747
16.
The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes.
J Cell Sci
; 126(Pt 16): 3575-84, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23781028
17.
Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation.
J Exp Med
; 221(7)2024 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38753246
18.
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
J Cell Sci
; 124(Pt 10): 1726-38, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21525037
19.
Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
J Biol Chem
; 286(37): 32651-60, 2011 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21784859
20.
The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.
Biochem Biophys Res Commun
; 417(4): 1151-7, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22227194