Detalhe da pesquisa
1.
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Bioorg Med Chem
; 46: 116347, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34507163
2.
STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice.
J Immunol
; 199(10): 3453-3465, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29055004
3.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.
Prostaglandins Other Lipid Mediat
; 136: 23-32, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29605541
4.
Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis.
J Biol Chem
; 291(13): 6626-40, 2016 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26757816
5.
Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation.
Mediators Inflamm
; 2017: 5420718, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400678
6.
Lipids and immunoinflammatory pathways of beta cell destruction.
Diabetologia
; 59(4): 673-8, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26868492
7.
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.
Diabetologia
; 58(3): 549-57, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25417214
8.
Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes.
Diabetologia
; 57(3): 491-501, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24429578
9.
Macrophage Specific Lipoxygenase Deletion Amplify Cardiac Repair Activating Tregs in Chronic Heart Failure.
J Leukoc Biol
; 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38785336
10.
Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1.
Arterioscler Thromb Vasc Biol
; 32(2): 247-56, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22199371
11.
12- and 15-lipoxygenases in adipose tissue inflammation.
Prostaglandins Other Lipid Mediat
; 104-105: 84-92, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22951339
12.
Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr -/- mice.
bioRxiv
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865098
13.
Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr-/- mice.
Front Cardiovasc Med
; 10: 1175673, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37396582
14.
Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.
Commun Biol
; 6(1): 967, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783748
15.
The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner.
Br J Pharmacol
; 180(20): 2677-2693, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259182
16.
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Am J Physiol Endocrinol Metab
; 302(6): E654-65, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22215650
17.
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.
Crit Care
; 16(5): R166, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22973824
18.
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.
Mediators Inflamm
; 2012: 851798, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23326022
19.
The AAV-PCSK9 murine model of atherosclerosis and metabolic dysfunction.
Eur Heart J Open
; 2(3): oeac028, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35919346
20.
Proinflammatory signaling in islet ß cells propagates invasion of pathogenic immune cells in autoimmune diabetes.
Cell Rep
; 39(13): 111011, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35767947