RESUMO
OBJECTIVES: To compare clinical, radiographic, biological and technical long-term outcomes of two types of dental implants over a period of 10 years. MATERIALS AND METHODS: Ninety-eight implants were placed in 64 patients, randomly allocated to one of two manufacturers (AST and STM). All implants were loaded with fixed restorations. Outcome measures were assessed at implant insertion (Ti), at baseline examination (TL), at 1, 3, 5, 8 and 10 (T10) years. Data analysis included survival, bone level changes, complications and clinical measures. RESULTS: Re-examination was performed in 43 patients (23 AST and 20 STM) at 10 years. The implant level analysis was based on 37 (AST) and 32 (STM) implants. Survival rates of 100% were obtained for both groups. The median changes of the marginal bone levels between baseline and T10 (the primary endpoint) amounted to a loss of 0.07 mm for group AST and a gain of 0.37 mm for group STM (intergroup p = 0.008). Technical complications occurred in 27.0% of the implants in group AST and in 15.6% in group STM. The prevalence of peri-implant mucositis was 29.7% (AST) and 50.1% (STM). The prevalence of peri-implantitis amounted to 0% (AST) and 6.3% (STM). CONCLUSIONS: Irrespective of the implant system used, the survival rates after 10 years were high. Minimal bone level changes were observed, statistically significant but clinically negligible in favor of STM. Technical complications were more frequently encountered in group AST, while group STM had a higher prevalence of peri-implant mucositis.
Assuntos
Perda do Osso Alveolar , Implantes Dentários , Mucosite , Peri-Implantite , Humanos , Prótese Dentária Fixada por Implante/efeitos adversos , Falha de Restauração Dentária , Implantação Dentária Endóssea/efeitos adversos , Peri-Implantite/etiologia , Peri-Implantite/complicações , Seguimentos , Perda do Osso Alveolar/etiologiaRESUMO
OBJECTIVES: To describe the methodology of the "L-shape" technique in guided bone regeneration (GBR) with simultaneous implant placement and report on the clinical, esthetic, and patient satisfaction outcomes up to 14 years of follow-up. MATERIAL AND METHODS: Fourteen patients treated with the "L-shape" technique were included in this retrospective study. The L-shape technique was performed by trimming and placing a soft-type bone block made of deproteinized bovine bone mineral with 10% collagen at the buccal-occlusal aspect of the dental implant. The remaining gaps were filled with deproteinized bovine bone mineral granules and the augmented area was covered with a collagen membrane. The following parameters were recorded: probing depth (PD), bleeding on probing (BOP), plaque index (PI), keratinized tissue width (KT) and marginal bone level (MBL). Esthetic outcomes were assessed according to the pink esthetic score (PES) and the white esthetic score (WES). Patient satisfaction was evaluated by means of a numerical rating scale (0-10). The stability of each augmented site was assessed by measuring the volumetric changes between baseline (crown delivery) and the respective follow-up. RESULTS: A total of 13 maxillary incisors and one maxillary canine in 14 patients were included. The mean follow-up period was 7.7 ± 3.8 years. PES values amounted to 10.7 ± 3.3 and WES to 8.8 ± 1.4. Patient satisfaction reached 9.4 ± 0.8. Mean PD at implant sites were 2.7 ± 0.7 mm while BOP amounted to 15.0 ± 0.2% and Pl to 5.0 ± 0.0%. Volumetric analyses revealed minimal changes at the augmented sites irrespective of the region of interest. Radiographic MBL remained relatively stable. CONCLUSIONS: Within the limitation of the present study the L-shape augmentation procedure seems to be a reliable technique when performing GBR with simultaneous implant placement in the esthetic zone. Outcomes encompassed stable clinical and esthetic results accompanied by high levels of patient satisfaction. Future randomized controlled trials are warranted to confirm possible benefits of the L-shape technique over traditional approaches. CLINICAL SIGNIFICANCE: The L-shape appears to be a simple yet promising technique in GBR with simultaneous implant placement that can easily be translated into clinical practice.
Assuntos
Implantação Dentária Endóssea , Implantes Dentários para Um Único Dente , Animais , Bovinos , Implantação Dentária Endóssea/métodos , Estudos Retrospectivos , Resultado do Tratamento , Estética Dentária , Regeneração Óssea , Maxila/cirurgiaRESUMO
OBJECTIVES: To test whether early implant placement with alveolar ridge preservation (ARP) results in different esthetic, clinical and patient-reported outcome measures (PROMs) compared with early implant placement without ARP. MATERIAL AND METHODS: Seventy-five patients requiring single tooth extraction in the anterior maxilla were recruited. Following tooth extraction, the patients were randomly allocated to three groups: (a) ARP using demineralized bovine bone mineral containing 10% collagen (DBBM-C) covered by a collagen matrix (CM) (n = 25), (b) ARP using DBBM-C covered with a palatal graft (PG) (n = 25) and (c) spontaneous healing (control) (n = 25). Eight weeks after tooth extraction, a CBCT was taken and early implant placement was performed in all patients. Esthetic, clinical and PROMs were evaluated one year post-loading. RESULTS: A total of 70 patients were available for re-examination at one year post-loading. The median mid-facial mucosal margin change amounted to -0.02 mm (IQR -0.27-0.46) in the CM group, -0.13 mm (IQR -0.44-0.25) in the PG group and -0.14 mm (IQR -0.29-0.07) in the control group, with no significant differences between the groups. Mean PES scores amounted to 7.0 ± 1.4 in the CM group, 7.1 ± 1.5 in the PG group and 7.3 ± 1.7 in the control group without significant differences between the groups. Plaque, bleeding on probing and probing depth did not differ between treatment groups. PROMs in general revealed no significant differences between the groups. CONCLUSION: Early implant placement with ARP using either a collagen matrix or a palatal graft rendered similar esthetic, clinical and PROMs to early implant placement without ARP. When a failing tooth can be replaced with an implant within 2 months after tooth extraction, the added value of ARP might be clinically negligible.
Assuntos
Aumento do Rebordo Alveolar , Implantes Dentários , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/cirurgia , Animais , Bovinos , Estética , Humanos , Medidas de Resultados Relatados pelo Paciente , Extração Dentária , Alvéolo Dental/diagnóstico por imagem , Alvéolo Dental/cirurgiaRESUMO
OBJECTIVES: To compare two ridge preservation techniques and spontaneous healing in terms of hard and soft tissue changes 2 months after tooth extraction. MATERIAL AND METHODS: The study was designed as a randomized controlled trial and included 75 patients. After single tooth extraction in the maxillary incisor/premolar area, patients were randomly allocated to one of the following groups: (a) ridge preservation with a xenogeneic bone substitute covered with a collagen matrix (CM-group), (b) ridge preservation with a xenogeneic bone substitute covered with a free palatal graft (PG-group) or (c) spontaneous healing (control). Eight weeks after tooth extraction, implants were placed and clinical, profilometric and radiographic evaluations were performed. In addition, the need for further guided bone regeneration (GBR) at implant placement was assessed. The differences between the treatment groups were compared with the One-way ANOVA or Kruskal-Wallis test with the corresponding post hoc analysis. The proportions of the categorical parameters were compared with the Fisher´s exact test. RESULTS: Seventy-five patients underwent early implant placement 8 weeks after tooth extraction and were evaluated. CM-group (-0.9 SD 0.6 mm) and PG-group (-1.0 SD 0.8 mm) showed less horizontal bone resorption compared to the control group (-3.2 SD 2.1 mm) (p < .001). Moreover, the necessity of GBR at implant placement was significantly less in CM-group (32%) and PG-group (24%) when compared to control group (72%) (p = .001). Patients in CM-group experienced less pain than PG-group, one week after tooth extraction (p = .042). No significant differences were found regarding graft evaluation, post-operative complications, and soft tissue contour. CONCLUSIONS: Ridge preservation using a xenogeneic bone substitute covered with a collagen matrix or a palatal graft, results in less bone resorption and fewer GBR procedures at early implant placement compared to spontaneous healing.
Assuntos
Aumento do Rebordo Alveolar , Implantes Dentários , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/cirurgia , Humanos , Extração Dentária/efeitos adversos , Alvéolo Dental/diagnóstico por imagem , Alvéolo Dental/cirurgiaRESUMO
OBJECTIVES: To assess clinical and radiographic outcomes as well as the profilometric contour alterations of peri-implant hard and soft tissues around single implants treated with simultaneous guided bone regeneration (GBR) at 5 years. MATERIALS AND METHODS: Twenty-seven patients presenting with a single tooth gap in the esthetic zone received a two-piece implant. GBR was randomly performed using a resorbable (RES) or a non-resorbable membrane (N-RES) combined with a bone substitute material. Follow-up examinations were performed at baseline (BL = crown insertion), 1 year (FU-1), 3 years (FU-3), and at 5 years (FU-5) including clinical and radiographic parameters as well as profilometric changes. Statistics were performed by means of parametric and nonparametric tests. RESULTS: At 5 years, 20 out of 27 patients (9 RES, 11 N-RES) were re-examined. Median values for probing depth changed insignificantly between BL and FU-5 in both groups. The median marginal bone levels were located 0.23 mm (0.06; 0.46; RES) and 0.17 mm (0.13;0.28; N-RES) below the implant shoulder at FU-5 (changes over time p < .05). The calculated median profilometric change between BL and FU-5 was -0.28 mm (-0.53;-0.20; RES; p = .016) and -0.24 mm (-0.43;0.08; N-RES; p = .102; intergroup p = .380). The horizontal bone thickness decreased significantly between re-entry and FU-5 for group RES at all measured levels (p < .05) measuring 0.87 mm (0.0; 2.05) at the implant shoulder, whereas the decrease for group N-RES was insignificant (p = .031) with 0 mm (0; 0.84) at the implant shoulder at 5 years. CONCLUSIONS: Implants sites with concomitant GBR using a resorbable or non-resorbable membrane revealed stable marginal bone levels and clinical outcomes. Profilometric changes were clinically negligible over 5 years. The observed change in hard tissue thickness was partially compensated by an increase in soft tissue thickness.
Assuntos
Aumento do Rebordo Alveolar , Implantes Dentários , Regeneração Óssea , Implantação Dentária Endóssea , Estética Dentária , Regeneração Tecidual Guiada Periodontal , Humanos , Membranas Artificiais , Resultado do TratamentoRESUMO
AIM: To assess histopathological and histomorphometric outcomes of soft tissue volume augmentation procedures at pontic sites using a volume-stable cross-linked collagen matrix (VCMX) and a non-cross-linked collagen matrix (XCM). MATERIALS AND METHODS: In twelve adult beagle dogs, the mandibular premolars and first molar were hemisected and the mesial root extracted. Soft tissue augmentation was randomly performed using VCMX, XCM, or a sham-operated control. Sacrifice was performed after 4, 8, and 26 weeks. Non-decalcified sections were analyzed for histopathologic and histomorphometric measurements at four different levels below the crest (1.5, 2.5, 3.5, and 5.5 mm). RESULTS: Group VCMX presented a greater overall amount of soft tissue at all healing time points, more pronounced fibroblast ingrowth, vascularization, and a substantial new collagen deposition. Over time, group XCM demonstrated faster signs of degradation compared with group VCMX. Four weeks after augmentation, group VCMX yielded a higher mean ridge width compared with groups XCM (2.22 mm VCMX, 0.89 mm XCM (at 2.5 mm); 2.05 mm VCMX, 0.80 mm XCM (at 3.5 mm) p < 0.05) and sham (0.59 mm sham (at 1.5 mm); 0.48 mm (at 2.5 mm); 0.44 mm (at 3.5 mm) p < 0.05). After healing periods of 8 and 26 weeks, measurements in group VCMX remained significantly higher compared with group sham both at 8 weeks (levels of 1.5 mm, 2.5 mm and 5.5 mm) and at 26 weeks (levels of 1.5 mm, 3.5 mm and 5.5 mm) (p < 0.05). CONCLUSION: The use of a cross-linked collagen matrix resulted in a greater and more stable ridge width over time compared with control groups. CLINICAL RELEVANCE: Soft tissue volume augmentation at pontic sites is more effective when using a cross-linked compared with a non-cross-linked collagen matrix.
Assuntos
Aumento do Rebordo Alveolar , Tecido Conjuntivo , Animais , Colágeno , Tecido Conjuntivo/transplante , Arco Dental , Prótese Parcial Fixa , Cães , Raiz DentáriaRESUMO
OBJECTIVE: To follow-up the radiographic changes in peri-implant bone of short (6 mm, test group) and long (10 mm, control group) single-unit implants five years after loading. MATERIALS AND METHODS: Forty-three implants of the test and 44 implants of the control group could be reassessed from 96 originally included implants. Standardized areas of interest (AOI) were defined in the peri-implant bone at pre-defined locations at mid-length on both sides of the implants, and at the apex. An arbitrary mean grey scale value (GSV) was calculated for the AOI after brightness calibration of the radiographs. Changes for GSV were calculated and tested for possible inter- and intra-group differences using the Mann-Whitney and Wilcoxon tests. RESULTS: The calculated intra-group differences between baseline and 5 years in the test group accounted for 2.4 ± 19.6 (i.e. slight brightening) and -6.2 ± 20.2 for the control group (i.e. slight shading), which resulted in a statistically significant difference in GSV change (p < .05). Crown-to-implant ratio was the only parameter showing an effect on GSV change (p = .001). CONCLUSIONS: Assessing conventional radiographs, longer implants showed a slightly stronger change of radiopacity of the peri-implant bone (slight loss of density) than short ones (slightly enhanced density) after five years of loading.
Assuntos
Perda do Osso Alveolar , Implantes Dentários , Coroas , Implantação Dentária Endóssea , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Falha de Restauração Dentária , Seguimentos , Resultado do TratamentoRESUMO
OBJECTIVES: To radiographically evaluate the effect of the adjunctive use of tenting screws (TS) for primary horizontal guided bone regeneration (GBR). MATERIALS & METHODS: Twenty-eight patients in need of staged bone augmentation were consecutively treated in a private practice. A xenogenic particulate bone substitute material (DBBM) and a resorbable collagen membrane were used in all patients. Subjects were divided into two groups: control (conventional GBR; n = 22) and test (tenting screws in conjunction with GBR - TS; n = 22). CBCT images were obtained before augmentation and after 6-8 months. CBCTs were superimposed, and linear horizontal measurements were performed. Alveolar ridge width (RW) and ridge width change (RWchange) were assessed at 1, 3, 5, and 7 mm below the bone crest. RESULTS: Forty-four sites in 28 patients were evaluated. No differences between the groups were detected for RW at baseline (TS: 5.87 ± 2.41; control: 5.36 ± 1.65). Regarding RWchange, TS promoted an additional effect at 1 and 3 mm below the crest compared to control (p < .05; RWchange-1 TS: 3.72 ± 2.46; control: 1.25 ± 3.05; RWchange-3 TS: 3.98 ± 2.53; control: 2.50 ± 2.02). The final RW was greater in group TS compared to the control group at the 1, 3, and 5 mm level (p < .05). CONCLUSIONS: The use of tenting screws exerted a positive effect on staged GBR with a greater final RW at the 3 mm level. In addition, GBR in conjunction with TS was able to provide consistent bone augmentation at lingual/palatal sites.
Assuntos
Aumento do Rebordo Alveolar , Regeneração Óssea , Parafusos Ósseos , Tomografia Computadorizada de Feixe Cônico , Implantação Dentária Endóssea , Humanos , Estudos RetrospectivosRESUMO
AIM: The aim of the current systematic review was to critically appraise evidence from randomized and prospective non-randomized comparative clinical trials about the efficacy of lateral bone augmentation prior to implant placement and their outcome regarding bone width gain. MATERIALS AND METHODS: Eight databases were searched until May 2018 for randomized and prospective non-randomized comparative trials on lateral bone augmentation prior to implant placement. After elimination of duplicate studies, data extraction and risk-of-bias assessment according to the Cochrane guidelines, random-effects meta-analyses of mean differences (MD) or relative risks (RR) and their 95% CIs were performed, followed by subgroup, meta-regression and sensitivity analyses. RESULTS: Overall, 25 trials (16 randomized/9 non-randomized) were identified, which included a total of 553 patients (42.2% male; mean age of 43.9 years). In these included studies and populations, various modalities for primary lateral bone augmentation rendered implant placement feasible. Small discrepancies were found between overall clinical and radiographic gain (pooled gains of 3.45 ± 1.18 mm versus 2.90 ± 0.83 mm, respectively), but were not statistically significant. Bone width gain was significantly inversely associated with baseline bone width (pooled effect: -0.35 mm/mm; 95% CI: -0.63 to -0.07 mm; p = 0.01). Additionally, % graft resorption was associated with patient age (36%/year, 95% CI: -0.62 to -0.11 mm; p = 0.01). The presence of xenograft added to autologous graft led to less resorption compared to autologous graft alone (MD: 1.06 mm; 95% CI: 0.21 to 1.92 mm; p = 0.01). Barrier membrane did not yield significant difference in terms of bone width gain (MD: -0.33 mm; 95% CI: -2.24 to 1.58 mm; p > 0.05) and graft resorption (MD: 0.84 mm; 95% CI: -1.42 to 3.09 mm; p > 0.05). However, the quality of evidence ranged from very low to moderate due to bias and imprecision. CONCLUSIONS: Initially smaller bone dimensions are associated with favours larger bone width gain, which indicates that a severe lateral bone deficiency can be effectively augmented applying primary lateral bone augmentation. Both Patients' age and recipient site (maxilla or mandible) seem to influence graft resorption. The addition of a xenograft can be helpful in reducing graft resorption. Existing evidence from randomized and prospective non-randomized trials on humans indicates that lateral bone augmentation prior to implant placement can successfully increase bone width. There are some indications that patient-related, site-related, and technique-related characteristics might influence the amount of gained bone width, but the quality of evidence is for the most part hampered by the small number of existing studies and methodological limitations that might lead to bias.
Assuntos
Aumento do Rebordo Alveolar , Implantes Dentários , Adulto , Transplante Ósseo , Implantação Dentária Endóssea , Xenoenxertos , Humanos , Mandíbula , Maxila , Estudos ProspectivosRESUMO
BACKGROUND AND AIMS: Bone augmentation procedures to enable dental implant placement are frequently performed. The remit of this working group was to evaluate the current evidence on the efficacy of regenerative measures for the reconstruction of alveolar ridge defects. MATERIAL AND METHODS: The discussions were based on four systematic reviews focusing on lateral bone augmentation with implant placement at a later stage, vertical bone augmentation, reconstructive treatment of peri-implantitis associated defects, and long-term results of lateral window sinus augmentation procedures. RESULTS: A substantial body of evidence supports lateral bone augmentation prior to implant placement as a predictable procedure in order to gain sufficient ridge width for implant placement. Also, vertical ridge augmentation procedures were in many studies shown to be effective in treating deficient alveolar ridges to allow for dental implant placement. However, for both procedures the rate of associated complications was high. The adjunctive benefit of reconstructive measures for the treatment of peri-implantitis-related bone defects has only been assessed in a few RCTs. Meta-analyses demonstrated a benefit with regard to radiographic bone gain but not for clinical outcomes. Lateral window sinus floor augmentation was shown to be a reliable procedure in the long term for the partially and fully edentulous maxilla. CONCLUSIONS: The evaluated bone augmentation procedures were proven to be effective for the reconstruction of alveolar ridge defects. However, some procedures are demanding and bear a higher risk for post-operative complications.
Assuntos
Aumento do Rebordo Alveolar , Implantes Dentários , Levantamento do Assoalho do Seio Maxilar , Processo Alveolar , Regeneração Óssea , Transplante Ósseo , Consenso , Implantação Dentária EndósseaRESUMO
OBJECTIVES: To investigate whether one of two synthetic bone substitute materials used for ridge preservation in the extraction sockets with buccal dehiscence defects was superior regarding new bone formation and ridge preservation and to compare it to sites left for spontaneous healing. MATERIALS AND METHODS: In sixteen dogs, P3 and P4 were hemi-sectioned and the respective distal roots were extracted. Following the preparation of a mucoperiosteal flap without vertical releasing incisions, 50% of the buccal bone was carefully removed. The extraction sites were randomly assigned either to a ridge preservation procedure (alloplastic bone substitute material (two test groups)) or to spontaneous healing (control group). Descriptive histology and histomorphometric analyses were performed at healing times of 4, 8, and 16 weeks. In case of homogeneous variances, the results were analyzed by one-way ANOVA, followed by Tukey's post-hoc test. If inhomogeneous, the data was analyzed using Welch-type ANOVA, followed by the Games-Howell post-hoc test. RESULTS: The use of bone substitute material led to significantly greater horizontal dimensions amounting to 3.3 mm (SD = 0.67; test 1) and 3.5 mm (SD = 0.72; test 2) compared to spontaneous healing (1.7 mm, SD = 0.23) at 16 weeks of healing (p < 0.0001). A significant difference was observed between spontaneous healing and the test groups in terms of newly formed bone tissue at 4, 8, and 16 weeks (p = 0.001), with values reaching 7.9, 21.8, and 36.8% (test 1), 5.0, 10.4, and 29% (test 2), and 26.2, 43.5, and 56.4% (control), but there were no significant differences between the test groups (p > 0.05). The final ridge profile was more favorable after ridge preservation (p < 0.001) as demonstrated by a loss of 28.8% (spontaneous healing) and an increase in both test groups at 16 weeks (test 1 = 60.5% and test 2 = 31.2%). CONCLUSIONS: The use of alloplastic materials rendered greater horizontal dimensions and a more favorable maintenance of the ridge profile. CLINICAL RELEVANCE: Alloplastic bone substitute materials can successfully be used for ridge preservation procedures.
Assuntos
Aumento do Rebordo Alveolar , Substitutos Ósseos , Extração Dentária , Animais , Cães , Distribuição Aleatória , Alvéolo Dental , CicatrizaçãoRESUMO
AIM: To assess volumetric and linear changes following ridge preservation (RP) or spontaneous healing plus early implant placement with or without simultaneous guided bone regeneration (GBR). MATERIALS AND METHODS: In eight adult beagle dogs, the mesial roots of the mandibular P3, P4 and M1 were extracted. Sites were randomized to either ridge preservation (RP) or spontaneous healing (SH). Four weeks later dental implants were placed either with (RP2) or without removing non-integrated DBBM (RP1). In RP2 and SH sites, GBR was applied using a demineralized bovine bone mineral and a resorbable membrane. Impressions were taken postextraction (SH)/postridge preservation (RP1; RP2), before and after implant placement and after healing of 4 and 12 weeks. Casts were digitized to allow for superimposition and measurement of contour alterations. RESULTS: Median ridge width reduction from postextraction (SH)/postridge preservation (RP1;RP2) to implant placement ranged from -13.9% (SH) to -19.7% (RP) (p > .05), whereas from implant placement to sacrifice, it was statistically significantly lower in group RP1 (-5.5%) compared to group SH (-23.4%; p = .0013) and group RP2 (-22.1%; p = .0026). Encompassing the entire study period, median ridge width changes ranged between -17.8% (SH), -24.8% (RP2) and -32.5% (RP1) (p > .05). CONCLUSIONS: Irrespective of the treatment modality and the healing period, part of the ridge contour was lost. Early implant placement after ridge preservation without additional GBR resulted in a more stable ridge contour after implant placement compared to controls.
Assuntos
Perda do Osso Alveolar/prevenção & controle , Processo Alveolar/anatomia & histologia , Aumento do Rebordo Alveolar/métodos , Regeneração Óssea , Implantação Dentária Endóssea , Regeneração Tecidual Guiada , Cicatrização , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/fisiologia , Processo Alveolar/cirurgia , Animais , Cães , Masculino , Modelos Animais , Distribuição AleatóriaRESUMO
OBJECTIVES: To assess two- and three-dimensional changes of the peri-implant tissues as well as clinical, biological, and radiological outcomes of implants having been treated with resorbable or nonresorbable membranes at 3 years. MATERIALS AND METHODS: Twenty-three patients were re-examined after having received a single-tooth implant in the esthetic zone in conjunction with guided bone regeneration (GBR) using either a resorbable (RES) or a titanium-reinforced nonresorbable membrane (N-RES) and demineralized bovine bone mineral. Volumetric and linear as well as clinical and radiographic measurements were performed at crown insertion (baseline), at 1 year (FU-1) and 3 years (FU-3). Statistics were performed by means of parametric and nonparametric tests. RESULTS: Minor, but ongoing buccal volume loss was observed in both groups during the 3-year follow-up. A slightly higher volume loss was observed in group RES (-0.22 mm) compared to N-RES (-0.14 mm) at 1 year (FU-1), but aligned at 3 years (FU-3) RES (-0.30 mm) N-RES (-0.32 mm). All changes over time were statistically significantly different within (p < .05), but not between the groups (p > .05). Stable median interproximal bone levels after 3 years (FU-3); 0.26 mm (0.04; 0.36) (RES) and 0.14 mm (0.08; 0.20) (N-RES) and healthy tissues (BOP, PD) were obtained with both membranes. CONCLUSIONS: Both treatment modalities resulted in minor, but ongoing contour changes of the peri-implant tissues. Stable interproximal bone levels and healthy tissues can be obtained with membranes up to 3 years.
Assuntos
Aumento do Rebordo Alveolar/métodos , Regeneração Tecidual Guiada Periodontal/métodos , Substitutos Ósseos/uso terapêutico , Implantação Dentária Endóssea , Implantes Dentários para Um Único Dente , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: To review the dental literature in terms of soft tissue augmentation procedures and their influence on peri-implant health or disease in partially and fully edentulous patients. METHODS: A MEDLINE search from 1966 to 2016 was performed to identify controlled clinical studies comparing soft tissue grafting versus no soft tissue grafting (maintenance) or two types of soft tissue grafting procedures at implant sites. The soft tissue grafting procedures included either an increase of keratinized tissue or an increase of the thickness of the peri-implant mucosa. Studies reporting on the peri-implant tissue health, as assessed by bleeding or gingival indices, were included in the review. The search was complemented by an additional hand search of all selected full-text articles and reviews published between 2011 and 2016. The initial search yielded a total number of 2,823 studies. Eligible studies were selected based on the inclusion criteria (finally included: four studies on gain of keratinized tissue; six studies on gain of mucosal thickness) and quality assessments conducted. Meta-analyses were applied whenever possible. RESULTS: Soft tissue grafting procedures for gain of keratinized tissue resulted in a significantly greater improvement of gingival index values compared to maintenance groups (with or without keratinized tissue) [n = 2; WMD = 0.863; 95% CI (0.658; 1.067); p < .001]. For final marginal bone levels, statistically significant differences were calculated in favor of an apically positioned flap (APF) plus autogenous grafts versus all control treatments (APF alone; APF plus a collagen matrix; maintenance without intervention [with or without residual keratinized tissue]) [n = 4; WMD = -0.175 mm; 95% CI: (-0.313; -0.037); p = .013]. Soft tissue grafting procedures for gain of mucosal thickness did not result in significant improvements in bleeding indices over time, but in significantly less marginal bone loss over time [WMD = 0.110; 95% CI: 0.067; 0.154; p < .001] and a borderline significance for marginal bone levels at the study endpoints compared to sites without grafting. CONCLUSIONS: Within the limitations of this review, it was concluded that soft tissue grafting procedures result in more favorable peri-implant health: (i) for gain of keratinized mucosa using autogenous grafts with a greater improvement of bleeding indices and higher marginal bone levels; (ii) for gain of mucosal thickness using autogenous grafts with significantly less marginal bone loss.
Assuntos
Aumento do Rebordo Alveolar/métodos , Implantação Dentária Endóssea , Implantes Dentários , Gengiva/cirurgia , Gengiva/transplante , Perda do Osso Alveolar , Colágeno/uso terapêutico , Tecido Conjuntivo/transplante , Bases de Dados Factuais , Índice de Placa Dentária , Gengivoplastia/métodos , Humanos , Arcada Parcialmente Edêntula/cirurgia , Metanálise como Assunto , Mucosa Bucal/cirurgia , Mucosa Bucal/transplante , Índice Periodontal , Retalhos CirúrgicosRESUMO
OBJECTIVES: The objective of this study was to test whether or not soft tissue augmentation with a volume-stable collagen matrix (VCMX) leads to similar volume gain around dental implants compared to autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS: In 12 adult beagle dogs, immediate implants were placed with simultaneous guided bone regeneration. After 25-45 weeks, soft tissue augmentation was randomly performed using VCMX, SCTG, or a sham-operated control. Impressions were taken pre-op and post-op (tissue augmentation) and again at sacrifice after healing periods of 4, 8, and 24 weeks. They were then digitized to allow for superimposition. Values of linear and volumetric changes were calculated. RESULTS: The median increase (pre-op to post-op) in buccal volume measured 0.92 mm for VCMX, 1.47 mm for SCTG, and 0.24 mm for SH. The values (pre-op to sacrifice) were - 0.25 mm for VCMX, 0.52 mm for SCTG, and - 0.06 mm for group SH. The median ridge width 2 mm below the crest measured - 0.26 mm for VCMX, 0.53 mm for SCTG, and - 0.15 mm for SH (pre-op to sacrifice). CONCLUSIONS: Volume augmentation using VCMX and SCTG resulted in an increase in ridge dimension (pre- to post-op). During the follow-up, the volume decreased in all three groups to a level close to the situation prior to surgery. CLINICAL RELEVANCE: Soft tissue volume augmentation around dental implants is usually performed using the patient's own tissue. This therapy is associated with an increased morbidity due to a second surgical site. Soft tissue volume at implant sites can be augmented using VCMX and SCTG. The gain on top of the ridge appears not to be stable during the follow-up in both groups.
Assuntos
Colágeno/uso terapêutico , Tecido Conjuntivo/transplante , Implantes Dentários , Gengiva/cirurgia , Animais , Cães , Regeneração Tecidual Guiada Periodontal , Carga Imediata em Implante Dentário , MasculinoRESUMO
OBJECTIVE: To test whether or not one out of two alloplastic materials used for ridge preservation (RP) is superior to the other in terms of volumetric and linear ridge changes over time. MATERIALS AND METHODS: In 16 adult beagle dogs, the distal roots of P3 and P4 were extracted and 50% of the buccal bone plate removed. Ridge preservation was performed randomly using two different alloplastic bone grafting substitutes (poly lactic-co-glycolic acid (PLGA) coated biphasic calcium phosphate particles consisting of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (ß-TCP=test 1), (a biphasic calcium phosphate consisting 60% HA and 40% ß-TCP=test 2) and a resorbable collagen membrane or a control group (sham). Sacrifice was performed at three time-points (4, 8, 16 weeks later). Impressions were taken before extraction, after RP, and at sacrifice, allowing for assessment of volumetric changes. A multi-way ANOVA was computed, and partial Type-II F tests were performed. RESULTS: Both ridge preservation procedures minimized the volume loss compared to spontaneous healing. The median buccal volume changes between pre-extraction and sacrifice were - 1.76 mm (Q1 = - 2.56; Q3 = - 1.42) for test 1, - 1.62 mm (Q1 = - 2.06; Q3 = - 1.38) for test 2, and - 2.42 mm (Q1 = - 2.63; Q3 = - 2.03) for control. The mean ridge width measurements did not show statistically significant differences between test 1 (- 2.51 mm; Q1 = - 3.25; Q3 = - 1.70) and test 2 (- 2.04 mm; Q1 = - 3.82; Q3 = - 1.81) (p = 0.813), but between test and control (- 3.85 mm; Q1 = - 5.02; Q3 = - 3.27) (p = 0.003). CONCLUSIONS: Both RP techniques were successful in maintaining the buccal contour from pre-extraction to sacrifice to a similar extent and more favorable compared to spontaneous healing. CLINICAL RELEVANCE: Alloplastic materials can successfully be used for RP procedures.
Assuntos
Perda do Osso Alveolar , Aumento do Rebordo Alveolar , Substitutos Ósseos , Fosfatos de Cálcio , Hidroxiapatitas , Copolímero de Ácido Poliláctico e Ácido Poliglicólico , Deiscência da Ferida Operatória , Alvéolo Dental , Animais , Cães , Masculino , Perda do Osso Alveolar/prevenção & controle , Aumento do Rebordo Alveolar/métodos , Substitutos Ósseos/farmacologia , Fosfatos de Cálcio/farmacologia , Colágeno/farmacologia , Hidroxiapatitas/farmacologia , Membranas Artificiais , Copolímero de Ácido Poliláctico e Ácido Poliglicólico/farmacologia , Distribuição Aleatória , Deiscência da Ferida Operatória/cirurgia , Alvéolo Dental/cirurgia , Cicatrização/efeitos dos fármacosRESUMO
OBJECTIVES: Short dental implants are frequently placed, however, little is known about the effect of the loading force regarding an enhanced crown-to-implant ratio. The aim of this study was therefore to assess bone density changes after a 3-year period, on radiographs acquired from a randomized, controlled two-centre clinical study comparing implants of 6 and 10 mm of length. MATERIALS AND METHODS: Three predefined areas were chosen on standardized X-rays in order to assess grey-scale values of the peri-implant bone: One at the tip of the apex and two at half-length on the mesial and distal sides of the implant. Radiographs at all follow-up appointments had previously been calibrated using control fields in areas of constant density. RESULTS: Around short implants, peri-implant bone displayed significantly higher differences in grey-scale values (p = .031) after 3 years, indicating a higher degree of mineralization. This phenomenon was not observed around long implants. CONCLUSIONS: A higher degree of mineralization around short implants was recorded. Whether this finding goes along with hampered bone adaptability, and accordingly, higher failure rates of short implants must be studied further in long-term clinical trials.
Assuntos
Processo Alveolar/diagnóstico por imagem , Densidade Óssea/fisiologia , Implantes Dentários para Um Único Dente , Implantação Dentária Endóssea , Planejamento de Prótese Dentária , Feminino , Seguimentos , Humanos , Masculino , Osseointegração/fisiologia , Estudos ProspectivosRESUMO
AIM: The aim of this study was to test whether or not soft tissue augmentation with a collagen matrix (VCMX) leads to a similar increase in ridge width around dental implants compared to the use of an autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS: In 12 dogs, immediate dental implants were placed with simultaneous guided bone regeneration. Three months later, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to these sites [VCMX, SCTG, sham-operated group (control)]. Dogs were sacrificed at 1 (n = 4), 2 (n = 4) or 6 months (n = 4). Descriptive histology and histomorphometric measurements for soft tissue thickness were performed on non-decalcified sections. RESULTS: The horizontal soft tissue thickness was maximal at the most coronal level (alveolar crest) at 1 month (VCMX: 2.1 ± 1.6 mm; SCTG: 2.5 ± 1.7 mm; p = 0.877) and decreased until 6 months. At 6 months, the greatest mucosal thickness was at a level 3.5 mm below the crest (VCMX: 0.8 ± 0.3 mm; SCTG: 0.7 ± 0.2 mm) (p = 0.754). Control sites revealed no relevant soft tissue augmentation at any level and any time-point. Tissue integration for VCMX and SCTG were favourable with minimal inflammatory reactions. CONCLUSIONS: Soft tissue volume augmentation at implant sites was obtained to a similar extent using VCMX and SCTG up to 2 months. Thereafter, degradation and remodelling processes were enhanced leading to a minimal increase in soft tissue thickness at 6 months for VCMX and SCTG.
Assuntos
Colágeno , Gengiva/cirurgia , Carga Imediata em Implante Dentário , Animais , Tecido Conjuntivo/transplante , Cães , Gengiva/anatomia & histologia , Masculino , Tamanho do ÓrgãoRESUMO
AIM: To assess (i) bone regeneration around implants placed early in sites with or without ridge preservation and (ii) if the bone substitute material (DBBM-C) has to be removed at implant placement. MATERIALS AND METHODS: In eight beagle dogs, three sites were randomly assigned to ridge preservation (DBBM-C plus collagen matrix (CMX)) (two sites; RP) or spontaneous healing (1 site; SH). Four weeks later, in one of the RP sites, dental implants were placed without removing the DBBM-C (RP1), whereas in RP2 and SH sites all non-integrated DBBM-C and/or granulation tissue were removed before implant placement and concomitant GBR. Histomorphometric outcomes were assessed at 4 and 12 weeks. RESULTS: The median buccal fBIC (first bone-to-implant contact) was located more apical in groups RP1: 1.34 mm (0.09; 2.96) and RP2: 1.41 mm (0.54; 2.72) than in group SH: 0.79 mm (0.26; 1.50) (p = 0.452) at 4 weeks. At 12 weeks, median buccal fBIC values were for RP1: 0.88 mm (0.00; 2.33), for RP2: 0.16 mm (0.00; 1.33) and for SH: 0.00 mm (0.00; 0.98) (p = 0.362). BIC values increased over 12 weeks in all groups. CONCLUSIONS: Ridge preservation followed by early implant placement led to higher BIC values at 12 than at 4 weeks. There is no need to remove the biomaterial at implant placement to ensure osseointegration. No relevant differences were observed between the three groups for any outcome measure.
Assuntos
Aumento do Rebordo Alveolar , Regeneração Óssea , Substitutos Ósseos/uso terapêutico , Implantes Dentários , Processo Alveolar/patologia , Processo Alveolar/fisiologia , Processo Alveolar/cirurgia , Animais , Colágeno/uso terapêutico , Cães , Regeneração Tecidual Guiada Periodontal , Masculino , Osseointegração , Distribuição Aleatória , Fatores de Tempo , CicatrizaçãoRESUMO
PURPOSE: To test whether or not one of two membranes is superior for peri-implant-guided bone regeneration in terms of clinical and histologic outcomes. MATERIAL AND METHODS: In 27 patients, 27 two-piece dental implants were placed in single-tooth gaps in the esthetic area. Buccal dehiscence and/or fenestration-type defects were regenerated using demineralized bovine bone mineral and randomly covered with either a resorbable membrane (RES) or a titanium-reinforced non-resorbable membrane (N-RES). Clinical measurements included vertical defect resolution and the horizontal thickness of regenerated bone at implant placement and at 6 months. Statistics were performed by means of nonparametric testing. RESULTS: The remaining mean vertical defect measured 4 mm (±2.07) (RES) and 2.36 mm (±2.09) (N-RES) (P = 0.044) at baseline and 0.77 mm (±0.85) (RES) and 0.21 mm (±0.80) (N-RES) (P = 0.021) at re-entry. This translated into a defect resolution of 85% (RES) and 90.7% (N-RES) (P = 0.10). The horizontal thickness after augmentation measured 3.46 mm (±0.52) (RES) and 2.82 mm (±0.50) (N-RES) (P = 0.004). The mean loss in horizontal thickness from baseline to re-entry measured 2.23 mm (SD ±1.21) (RES) and 0.14 mm (±0.79) (N-RES) (P = 0.017). The horizontal changes in thickness at the implant shoulder level were statistically significant between the groups (P = 0.0001). CONCLUSIONS: Both treatment modalities were clinically effective in regenerating bone as demonstrated by a similar horizontal thickness and vertical defect fill at 6 months. The N-RES group exhibited significantly less horizontal bone thickness reduction from baseline to follow-up.