Comparison of 2D simultaneous multi-slice and 3D GRASE readout schemes for pseudo-continuous arterial spin labeling of cerebral perfusion at 3 T.

OBJECTIVE: In this perfusion magnetic resonance imaging study, the performances of different pseudo-continuous arterial spin labeling (PCASL) sequences were compared: two-dimensional (2D) single-shot readout with simultaneous multislice (SMS), 2D single-shot echo-planar imaging (EPI) and multishot three-dimensional (3D) gradient and spin echo (GRASE) sequences combined with a background-suppression (BS) module. MATERIALS AND METHODS: Whole-brain PCASL images were acquired from seven healthy volunteers. The performance of each protocol was evaluated by extracting regional cerebral blood flow (rCBF) measures using an inline morphometric segmentation prototype. Image data postprocessing and subsequent statistical analyses enabled comparisons at the regional and sub-regional levels. RESULTS: The main findings were as follows: (i) Mean global CBF obtained across methods was were highly correlated, and these correlations were significantly higher among the same readout sequences. (ii) Temporal signal-to-noise ratio and gray-matter-to-white-matter CBF ratio were found to be equivalent for all 2D variants but lower than those of 3D-GRASE. DISCUSSION: Our study demonstrates that the accelerated SMS readout can provide increased acquisition efficiency and/or a higher temporal resolution than conventional 2D and 3D readout sequences. Among all of the methods, 3D-GRASE showed the lowest variability in CBF measurements and thus highest robustness against noise.

Magnetic Resonance Elastography of the Brain.

Magnetic resonance elastography (MRE) is an emerging noninvasive technique, an alternative to palpation for quantitative assessment of biomechanical properties of tissue. In MRE, tissue stiffness information is obtained by a 3-step process, propagating mechanical waves in the tissues, measuring the wave propagation using modified magnetic resonance (MR) pulse sequences, and generating the quantitative stiffness maps from the MR images. MRE is clinically used in patients with liver diseases, whereas its applications in other organs are still being investigated. At present, the pediatric studies are in the initial stage and preliminary results promise to provide additional information about tissue characteristics.