1.
Genome Biol
; 23(1): 114, 2022 05 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35578363
RESUMO
Technological development has enabled the profiling of gene expression and chromatin accessibility from the same cell. We develop scREG, a dimension reduction methodology, based on the concept of cis-regulatory potential, for single cell multiome data. This concept is further used for the construction of subpopulation-specific cis-regulatory networks. The capability of inferring useful regulatory network is demonstrated by the two-fold increment on network inference accuracy compared to the Pearson correlation-based method and the 27-fold enrichment of GWAS variants for inflammatory bowel disease in the cis-regulatory elements. The R package scREG provides comprehensive functions for single cell multiome data analysis.
Assuntos
Cromatina , Sequências Reguladoras de Ácido Nucleico , Cromatina/genética , Expressão Gênica , Redes Reguladoras de Genes , Análise de Célula Única
2.