Detalhe da pesquisa
1.
Preclinical toxicology profile of squalene epoxidase inhibitors.
Toxicol Appl Pharmacol
; 401: 115103, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32522582
2.
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Proc Natl Acad Sci U S A
; 113(5): 1387-92, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787889
3.
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Proc Natl Acad Sci U S A
; 113(52): 15084-15089, 2016 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956631
4.
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.
J Immunother Cancer
; 10(5)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35606087
5.
Quantitation of ivosidenib in human plasma via LC-MS/MS and its application in clinical trials.
Bioanalysis
; 13(11): 875-889, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33998826
6.
Quantitation of uridine and L-dihydroorotic acid in human plasma by LC-MS/MS using a surrogate matrix approach.
J Pharm Biomed Anal
; 192: 113669, 2021 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33120310
7.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
J Clin Invest
; 131(10)2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822774
8.
Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach.
Bioanalysis
; 12(16): 1149-1159, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32757862
9.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33082276
10.
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun
; 10(1): 97, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626872
11.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626880
12.
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Leukemia
; 36(3): 869-872, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34743189
13.
Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis.
Toxicol Sci
; 151(2): 261-70, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26919959
14.
Simultaneous determination of oxysterols, cholesterol and 25-hydroxy-vitamin D3 in human plasma by LC-UV-MS.
PLoS One
; 10(4): e0123771, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25875771