RESUMO
BACKGROUND: As per Ayurveda, Nitya Sevaniya (NS) food items are recommended for daily intake while Nitya Asevaniya (NAS) food items should be avoided for daily intake due to their systemic wholesome and unwholesome effects after consumption, respectively. AIM AND OBJECTIVES: The present study was conducted to perform in vivo safety evaluation of selected Nitya Sevaniya and Nitya Asevaniya food items. MATERIALS AND METHODS: Thirty rats were randomly divided into five groups-each containing six Charle's Foster strain albino rats. Group 1 served as standard diet group, groups 2 and 3 served as test drug received groups namely NS50 and NS100, in which 50% and 100% mixture of Nitya Sevaniya food was administered, respectively. Group 4 and 5 as test drug received groups Nitya Asevaniya 50 (NAS50) and Nitya Asevaniya 100 (NAS100), in which 50% and 100% Nitya Asevaniya food mixtures was administered, respectively. The test diet was administered orally in the form of freshly prepared pellet twice a day ad libitum for 90 days. Parameters studied were gross behavior, body and organ weight, food and water intake, fecal and urine output, hematological and biochemical parameters, electrocardiogram and histology of various organs. RESULTS: In the NAS100 group, a significant change was observed in 20 of 47 parameters in view of pathological aspect. Among them, three parameters, i.e., platelet count, serum glutamic-oxaloacetic transaminase (SGOT) and indirect bilirubin were above normal limits, while other parameters were within the normal limits. No significant change was observed in any of the parameters in the NS50 and NS100 group after 90 days of administration as compared with the control group. CONCLUSION: Considering findings of this study, it is concluded that selected NS food items are safe while consumption of only selected Nitya Asevaniya food items (when administered in 100% dose) for 90 days have the potential of inflammatory changes in the liver, spleen; fat deposition in kidney and impairment of cardiac and renal functions.
RESUMO
BACKGROUND: Erycibe paniculata Roxb. (Family-Convolvulaceae) has been reported for its potential ethno medicinal value. Leaf, stem, bark, and root of this plant are being used either single or in the mixture of the whole part in different disease conditions by different tribes. AIMS AND OBJECTIVES: The aim and objective of this study is to assess the antioxidant activity of methanolic extracts of different parts (leaf, stem, bark, and root) of Erycibe paniculata Roxb (E. paniculata). MATERIALS AND METHODS: Different in-vitro assay such as free radical-scavenging assay by 2,2-diphenyl-1-picryl-hydrazyl-hydrate method, reducing power, super oxide radical scavenging, nitric oxide, and hydrogen peroxide scavenging assays were used to determine the antioxidant activity of different parts of E. paniculata. Ascorbic acid, sodium nitrite, and gallic acid were used as the standards for antioxidant activity. RESULTS: The percentage inhibition for all methods were plotted against different concentration and suggested that the obtained activities were concentration and dose depended. Inhibitory concentration (IC50) value of methanolic extract of leaf, stem, bark, and root of E. paniculata in different in vitro activities exhibited significant antioxidant activity. Methanolic extract of bark showed higher IC50 value in all antioxidant assays than other parts of E. paniculata. CONCLUSION: Methanolic extract of leaf, stem, bark, and root of E. paniculata has potential antioxidant activity.