[Pharmacodynamics, pharmacokinetics and clinical effectiveness of captopril in patients with hypertension]. / Farmakodinamika, farmakokinetika i klinicheskaia éffektivnost' kaptoprila u bol'nykh gipertonicheskoi bolezn'iu.

Captopril was tested for pharmacokinetics. Its hypotensive effect was compared with plasma renin activity (PRA) and blood captopril levels in single and prolonged administrations of its various doses in 58 hypertensive patients. When a single dose (25 mg) of captopril was given, a relationship was found between its hypotensive effect and higher blood concentration, baseline PRA. The detection rate of its antihypertensive effect was not related to the baseline PRA. The efficient and safe dose of captopril was shown to be 75-150 mg daily, maintaining its blood concentration within ranges of 75-175 ng/ml.

[Pharmacologic effects of peripheral vasodilators in patients with secondary pulmonary hypertension]. / Farmakologicheskie éffekty perifericheskikh vazodilatatorov u bo'lnykh so vtorichnoi legochnoi gipertenziei.

A single dose of capoten (25 mg) and prazosin (I mg) was given to 82 patients with stable pulmonary hypertension and chronic non-specific pulmonary diseases and to 34 patients with the above condition and arterial hypertension. Systolic and diastolic pressure in the system of the pulmonary artery and total pulmonary and total peripheral resistance were decreased; capoten exhibited more pronounced hypotensive effect. Unidirectional changes were revealed in the course treatment. Combined use of capoten, prazosin and euphilline produced the additional hypotensive effect on pulmonary circulation. Capoten and prazosin had no direct broncholytic effect.

[The effect of fenigidin (nifedipine) and verapamil on renin activity, the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension]. / Vliianie fenigidina (nifedipina) i verapamila na aktivnost' renina, uroven' ionizirovannogo kal'tsiia i al'dosterona v plazme krovi i pokazateli gemodinamiki u krys so spontannoi gipertenziei.

Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil.