RESUMO
The paper studies the modifications occurring in the prevalence of anti-protein gag antibodies during the evolution of the infection in a paediatric population iatrogenically infected and not submitted to antiretroviral treatment. The study was performed by annual clinical examination of children and by laboratory determinations: western-blot, p24 Ag assay, determination of lymphocyte population by flowcytometry. The predictive capacity of p17 antibodies was revealed, their occurrence after seroconversion pointing to a favourable evolution, with a longer asymptomatic period; the disappearance of these antibodies during the disease indicates a more advanced stage of the disease. The disappearance of p24 and p55 antibodies during the evolution of the disease shows a more advanced stage of the disease, both clinically and as concerning the immunosuppression degree.
Assuntos
Produtos do Gene gag/imunologia , Anticorpos Anti-HIV/sangue , Antígenos HIV/imunologia , Infecções por HIV/diagnóstico , Proteínas Virais , Biomarcadores/sangue , Pré-Escolar , Progressão da Doença , Proteína do Núcleo p24 do HIV/imunologia , Infecções por HIV/sangue , Infecções por HIV/imunologia , Humanos , Precursores de Proteínas/imunologia , Testes Sorológicos , Produtos do Gene gag do Vírus da Imunodeficiência HumanaRESUMO
In an attempt to elucidate the causes which led to the high percentage of HIV infection in the infantile population in Romania, the paper deals with the study of the evolution of the infection process, in the 0-6 years age group; the process was separately studied in children from closed collectivities (5,318 sera) and children living with their families (2,462). The study of the various patterns obtained with sera analysed by western-blot allowed of concluding that the massive spreading of the infection in both types of infantile population occurred in 1991-1992, the most intense process being reported in the 0-2 years age group (children from closed collectivities). The differences between the evolution of HIV infection epidemic in the above mentioned infantile populations and that noticed in adults are shown.
Assuntos
Sorodiagnóstico da AIDS , Infecções por HIV/epidemiologia , Adulto , Western Blotting , Criança , Pré-Escolar , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/transmissão , Ensaio de Imunoadsorção Enzimática , Contaminação de Equipamentos , Saúde da Família , Feminino , Infecções por HIV/imunologia , Infecções por HIV/transmissão , Soroprevalência de HIV , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Orfanatos/estatística & dados numéricos , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Prevalência , Kit de Reagentes para Diagnóstico , Romênia/epidemiologia , Estudos Soroepidemiológicos , Reação TransfusionalRESUMO
The paper is an attempt to study the effect of repeated boosters with Di-Te vaccine in positive children. The efficacy of their administration (vaccinal coverage degree, level of secreted antitoxins, the persistency of the immune response) and their influence upon the subsequent evolution of HIV infection are investigated.
Assuntos
Vacina contra Difteria e Tétano/imunologia , Infecções por HIV/imunologia , Adolescente , Criança , Antitoxina Diftérica/sangue , Anticorpos Anti-HIV/sangue , Humanos , Imunização Secundária , Antitoxina Tetânica/sangueAssuntos
Síndrome da Imunodeficiência Adquirida/etiologia , HIV-1/patogenicidade , HIV-2/patogenicidade , Síndrome da Imunodeficiência Adquirida/imunologia , Síndrome da Imunodeficiência Adquirida/microbiologia , Formação de Anticorpos/imunologia , Antígenos CD/imunologia , HIV-1/imunologia , HIV-2/imunologia , Humanos , Imunidade Celular/imunologia , Depleção Linfocítica , Sistema Nervoso/imunologia , Sistema Nervoso/microbiologiaRESUMO
I. Contribution of the reticuloendothelial system to the defence of the organism against endotoxins: phagocytic function, blood clearance and detoxifying function. II. Endotoxin--liver cell interaction. A) The effects of endotoxin on the parenchymatous liver cell; morphofunctional alterations: endotoxicosis as a "set of hepatic metabolic lesions". B) The sensitivity to endotoxin of organisms whose liver has undergone a functional alteration. III. Intrahepatic detoxification of endotoxin--an enzymatic process:--the role of enzymes oxidizing fatty acids;--the role of enzymes containing SH groups; --the role of tryptophane-oxygenase. IV. Conclusions.