Detalhe da pesquisa
1.
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(12): 3715-20, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21571529
2.
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2148-50, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20206516
3.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071223
4.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660943
5.
Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.
J Med Chem
; 50(21): 5161-7, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880055
6.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
7.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552