RESUMO
Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.
Assuntos
Acetatos/farmacologia , Antioxidantes/farmacologia , Inibidores da Agregação Plaquetária/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Difosfato de Adenosina/farmacologia , Animais , Peroxidação de Lipídeos/efeitos dos fármacos , Medições Luminescentes , Malondialdeído/sangue , Coelhos , Relação Estrutura-Atividade , Fatores de TempoAssuntos
Coagulação Sanguínea/efeitos dos fármacos , Diabetes Mellitus/sangue , Gliclazida/uso terapêutico , Compostos de Sulfonilureia/uso terapêutico , Adulto , Idoso , Diabetes Mellitus/tratamento farmacológico , Humanos , Pessoa de Meia-Idade , Agregação Plaquetária/efeitos dos fármacos , TromboelastografiaRESUMO
Experiments on rabbits proved that amidopyrin, sulphatizonicotinoilamine-guanidine, chlorpromazine, triphthazine, euphylline and tedamine inhibit aggregation of thrombocytes and unidirectionally have an effect on the carbohydrate metabolism enzymes in these cells, both in vitro and in vivo following their single and coursewise introduction. They also activate the lactate- and glyceraldehide-3-phosphate-dehydrogenase and reduce the activity of glucose-6-phosphate-dehydrogenase.
Assuntos
Plaquetas/enzimologia , Agregação Plaquetária/efeitos dos fármacos , Aminofilina/farmacologia , Aminopirina/farmacologia , Animais , Plaquetas/efeitos dos fármacos , Metabolismo dos Carboidratos , Clorpromazina/farmacologia , Ativação Enzimática/efeitos dos fármacos , Guanidinas/farmacologia , Técnicas In Vitro , Coelhos , Trifluoperazina/farmacologiaRESUMO
The influence of four agents--pyrazolidinedione derivatives on the ADP-induced aggregation and activity of glycolytic enzymes--glyceraldehydrophosphate dehydrogenase and lactate dehydrogenase (GAPD, LDG) and of the anatomic oxidation enzyme--glucose-6-phosphate dehydrogenase (G-6-PD) was studied. The substances known by a conventional designation of MYaK-38, No-13 and No-2 are shown to display an antiaggregational action. Amidopyrine was found to depress the adhesive capacity of blood platelets, to activate GAPD and LDG and to lower the activity of G-6-PD.