Detalhe da pesquisa
1.
Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559132
2.
Randomized, Double-Blind, Placebo-Controlled Studies of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Eravacycline.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30150464
3.
The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28784679
4.
Pyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacy.
Antimicrob Agents Chemother
; 59(4): 2337-42, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645840
5.
NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.
Antimicrob Agents Chemother
; 58(5): 2657-64, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24566174
6.
Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.
Bioorg Med Chem
; 22(19): 5392-409, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155913
7.
Discovery of bacterial NADâº-dependent DNA ligase inhibitors: improvements in clearance of adenosine series.
Bioorg Med Chem Lett
; 22(1): 85-9, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22154350
8.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
Antimicrob Agents Chemother
; 55(3): 1088-96, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21189350
9.
Assessment of in vivo efficacy of eravacycline against Enterobacteriaceae exhibiting various resistance mechanisms: a dose-ranging study and pharmacokinetic/pharmacodynamic analysis.
Int J Antimicrob Agents
; 51(5): 727-732, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29325762
10.
ETX2514 is a broad-spectrum ß-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Nat Microbiol
; 2: 17104, 2017 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28665414
11.
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Sci Rep
; 5: 11827, 2015 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26168713
12.
A path from primary protein sequence to ligand recognition.
Proteins
; 50(4): 589-99, 2003 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12577265
13.
Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection.
PLoS One
; 9(3): e90382, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24595353
14.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
J Med Chem
; 57(11): 4584-97, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24828090
15.
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.
J Med Chem
; 55(15): 6916-33, 2012 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22779424
16.
In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.
ACS Chem Biol
; 7(11): 1866-72, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22908966
17.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).
J Med Chem
; 55(22): 10010-21, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043329
18.
Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Sci Rep
; 5: 14157, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26383116
19.
Genome-wide profile of oxidoreductases in viruses, prokaryotes, and eukaryotes.
J Proteome Res
; 2(6): 626-32, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14692456