Detalhe da pesquisa
1.
P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.
Bioorg Med Chem Lett
; 21(5): 1532-5, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295466
2.
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Bioorg Med Chem Lett
; 21(5): 1536-40, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295467
3.
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
Bioorg Med Chem Lett
; 18(6): 2062-6, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291642
4.
9-hydroxyazafluorenes and their use in thrombin inhibitors.
J Med Chem
; 48(7): 2282-93, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801822
5.
Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors.
J Med Chem
; 47(12): 2995-3008, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15163182
6.
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles.
Bioorg Med Chem Lett
; 16(2): 338-42, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16257203
7.
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.
Bioorg Med Chem Lett
; 15(11): 2771-5, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911253
8.
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
Bioorg Med Chem Lett
; 13(16): 2781-4, 2003 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12873514
9.
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position.
Bioorg Med Chem Lett
; 13(20): 3477-82, 2003 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-14505652