Detalhe da pesquisa
1.
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist.
N Engl J Med
; 377(1): 28-40, 2017 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28525302
2.
Phase 2, double-blind, randomized, placebo-controlled study of the safety and efficacy of elagolix in women with polycystic ovary syndrome.
F S Rep
; 4(2): 206-212, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398623
3.
Low-Dose Elagolix for the Treatment of Heavy Menstrual Bleeding in Patients With Uterine Leiomyomas: A Randomized Controlled Trial.
Obstet Gynecol
; 142(5): 1068-1076, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37769311
4.
Pharmacokinetic and Pharmacodynamic Profiles of Ethinylestradiol/Norgestimate Combination or Norethindrone upon Coadministration with Elagolix 150 mg Once Daily in Healthy Premenopausal Women.
Clin Pharmacokinet
; 60(8): 1003-1013, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33748934
5.
Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.
Clin Transl Sci
; 14(4): 1611-1619, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33963686
6.
Quantitative Assessment of Elagolix Enzyme-Transporter Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.
Clin Pharmacokinet
; 59(5): 617-627, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31713224
7.
Effect of Elagolix Exposure on Clinical Efficacy End Points in Phase III Trials in Women With Endometriosis-Associated Pain: An Application of Markov Model.
CPT Pharmacometrics Syst Pharmacol
; 9(8): 466-475, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32621325
8.
Exposure-Safety Analyses Identify Predictors of Change in Bone Mineral Density and Support Elagolix Labeling for Endometriosis-Associated Pain.
CPT Pharmacometrics Syst Pharmacol
; 9(11): 639-648, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945631
9.
Assessment of Clinical Drug-Drug Interactions of Elagolix, a Gonadotropin-Releasing Hormone Receptor Antagonist.
J Clin Pharmacol
; 60(12): 1606-1616, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33045114
10.
Clinical Pharmacology of Elagolix: An Oral Gonadotropin-Releasing Hormone Receptor Antagonist for Endometriosis.
Clin Pharmacokinet
; 59(3): 297-309, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749075
11.
Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women.
J Clin Endocrinol Metab
; 105(3)2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31650182
12.
Elagolix Pharmacokinetic Profiles in Women With Renal or Hepatic Impairment.
Clin Pharmacol Drug Dev
; 8(8): 1053-1061, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570832
13.
Population Pharmacokinetics of Elagolix in Healthy Women and Women with Endometriosis.
Clin Pharmacokinet
; 57(10): 1295-1306, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29476499
14.
Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies.
Obstet Gynecol
; 132(1): 147-160, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889764
15.
Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by Elagolix in Healthy Premenopausal Women.
J Clin Endocrinol Metab
; 102(5): 1683-1691, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28323948
16.
Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study.
Fertil Steril
; 108(1): 152-160.e4, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28579415
17.
Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation.
Clin Pharmacol Ther
; 78(5): 486-500, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16321615
18.
Pharmacokinetic enhancement in HIV antiretroviral therapy: a comparison of ritonavir and cobicistat.
AIDS Rev
; 17(1): 37-46, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25586481
19.
Pharmacokinetics and safety of the lopinavir/ritonavir tablet 500/125 mg twice daily coadministered with efavirenz in healthy adult participants.
J Clin Pharmacol
; 52(8): 1248-54, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21719718
20.
A limited sampling model for estimation of total and unbound mycophenolic acid (MPA) area under the curve (AUC) in hematopoietic cell transplantation (HCT).
Ther Drug Monit
; 28(3): 394-401, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16778725