Plasma sLRP-1 Level Independently Relates to a Higher Risk of Moderate-Severe Stenosis by Gensini Score in Acute Coronary Syndrome Patients.

Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) plays a crucial role in facilitating inflammation, lipid accumulation, and atherosclerosis, and the latter factors are involved in the pathology of cardiovascular diseases. This study aimed to explore the ability of plasma sLRP-1 for reflecting stenosis degree in acute coronary syndrome (ACS) patients. sLRP-1 was detected from plasma by enzyme-linked immunosorbent assay in 169 ACS patients and 77 non-ACS subjects (as controls) after admission. Our study illustrated that sLRP-1 was increased in ACS patients versus controls (P < 0.001). Meanwhile, sLRP-1 was positively correlated with body mass index (P = 0.021), white blood cells (P = 0.009), neutrophils (P = 0.002), cardiac troponin I (P = 0.009), and brain natriuretic peptide (P = 0.008) in ACS patients. Notably, sLRP-1 was positively associated with the Gensini score (P = 0.002) and Gensini score stratified stenosis severity (P = 0.004) in ACS patients. After adjustment, sLRP-1 [odds ratio (OR) = 1.333, P = 0.045] independently estimated a higher risk of moderate-severe stenosis, so did numbers of coronary artery lesions (OR = 2.869, P = 0.001), but ejection fraction forecasted a lower risk (OR = 0.880, P = 0.012). Interestingly, a combination of sLRP-1, ejection fraction, and numbers of coronary artery lesions exhibited a good ability to estimate moderate-severe stenosis risk with an area under the curve (95% confidence interval) of 0.845 (0.783-0.906). In summary, increased plasma sLRP-1 represents an aggravated inflammation, impaired cardiac function, and especially a higher stenosis severity in ACS patients.

Metal-carbon hybrid materials induced persulfate activation: Application, mechanism, and tunable reaction pathways.

Proper wastewater treatment has always been the focus of human society, and many researchers have been working to find efficient and stable wastewater treatment technologies. Persulfate-based advanced oxidation processes (PS-AOPs) mainly rely on persulfate activation to form reactive species for pollutants degradation and are considered to be one of the most effective wastewater treatment technologies. Recently, metal-carbon hybrid materials have been diffusely used for PS activation because of their high stability, abundant active sites, and easy applicability. Metal-carbon hybrid materials can successfully overcome the shortcomings of onefold metal catalysts and carbon catalysts by combing the complementary advantages of the two components. This article reviews recent studies about metal-carbon hybrid materials-mediated PS-AOPs for wastewater decontamination. The interactions of metal and carbon materials, as well as the active sites of metal-carbon hybrid materials, are introduced first. Then, the application and mechanism of metal-carbon hybrid materials-mediated PS activation are presented in detail. Lastly, the modulation methods of metal-carbon hybrid materials and their tunable reaction pathways were discussed. The prospect of future development directions and challenges is proposed to facilitate metal-carbon hybrid materials-mediated PS-AOPs to take a step further for practical application.

A review of polybrominated diphenyl ethers and novel brominated flame retardants in Chinese aquatic environment: Source, occurrence, distribution, and ecological risk assessment.

Due to the widespread commercial production and use of brominated flame retardants (BFRs) in China, their potential impact on human health development should not be underestimated. This review searched the literature on Polybrominated diphenyl ethers and Novel brominated flame retardant (PBDEs and NBFRs) (broad BFRs) in the aquatic environment (including surface water and sediment) in China over the last decade. It was found that PBDEs and NBFRs entered the aquatic environment through four main pathways, atmospheric deposition, surface runoff, sewage effluent and microplastic decomposition. The distribution of PBDEs and NBFRs in the aquatic environment was highly correlated with the local economic structure and population density. In addition, a preliminary risk assessment of existing PBDEs and PBDEs in sediments showed that areas with high-risk quotient values were always located in coastal areas with e-waste dismantling sites, which was mainly attributed to the historical legacy of electronic waste. This research provides help for the human health development and regional risk planning management posed by PBDEs and NBFRs.