Detalhe da pesquisa
1.
CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition.
Drug Metab Dispos
; 52(5): 432-441, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485279
2.
Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection.
Antimicrob Agents Chemother
; 67(1): e0134822, 2023 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36519892
3.
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor.
Nature
; 531(7594): 386-9, 2016 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26983541
4.
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
Antimicrob Agents Chemother
; 65(9): e0060221, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34125594
5.
In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.
Drug Metab Dispos
; 48(12): 1283-1292, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037043
6.
Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.
Drug Metab Dispos
; 47(12): 1433-1442, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582395
7.
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
J Hepatol
; 68(5): 912-921, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247724
8.
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
J Hepatol
; 68(5): 922-931, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247725
9.
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
Antimicrob Agents Chemother
; 56(6): 3359-68, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22430955
10.
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Antimicrob Agents Chemother
; 56(7): 3767-75, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526308
11.
ß-D-2'-α-F-2'-ß-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Bioorg Med Chem Lett
; 22(18): 5924-9, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892115
12.
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.
Sci Transl Med
; 14(633): eabl8282, 2022 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34968150
13.
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
J Biol Chem
; 285(45): 34337-47, 2010 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20801890
14.
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methylguanosine.
Antimicrob Agents Chemother
; 55(6): 2566-75, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21444700
15.
Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.
Bioorg Med Chem Lett
; 21(15): 4642-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21704526
16.
Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.
Clin Transl Sci
; 14(5): 1924-1934, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34058067
17.
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Antimicrob Agents Chemother
; 54(8): 3187-96, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516278
18.
2'-deoxy-2'-α-fluoro-2'-ß-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorg Med Chem Lett
; 20(24): 7376-80, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21050754
19.
Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR).
Front Pharmacol
; 11: 620197, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33551819
20.
Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir.
Drug Metab Pharmacokinet
; 35(3): 334-340, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345577