Internally Functionalized Dendrimers Based on Fully Substituted 1,2,3-Triazoles.

Being one important class in dendrimer chemistry, internally functionalized dendrimers (IFDs) are still exiguous. Here, the first construction of IFDs involving fully substituted 1,2,3-triazole rings as interior functionality carriers is demonstrated. Through divergent or convergent synthetic protocols established on the efficient iridium-catalyzed annulation of internal 1-thioalkynes with organic azides, sequence-controlled heterolayered dendrimers with different branched structures are achieved in a convenient manner. 1 H NMR, mass spectrometry, and size exclusion chromatography characterizations well identify their architecture and high purity.