Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28562588
2.
A cocrystal structure of dengue capsid protein in complex of inhibitor.
Proc Natl Acad Sci U S A
; 117(30): 17992-18001, 2020 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32669438
3.
Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J Virol
; 94(24)2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32907977
4.
Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.
Adv Exp Med Biol
; 1062: 187-198, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29845534
5.
A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J Biol Chem
; 291(16): 8541-8, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26872970
6.
Structural basis of mycobacterial inhibition by cyclomarin A.
J Biol Chem
; 288(43): 30883-91, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24022489
7.
NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.
J Biol Chem
; 288(18): 12891-900, 2013 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23511634
8.
Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.
J Virol
; 87(9): 5291-5, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408636
9.
Ligand-bound structures of the dengue virus protease reveal the active conformation.
J Virol
; 86(1): 438-46, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22031935
10.
Key features of the interaction between Pcf11 CID and RNA polymerase II CTD.
Nat Struct Mol Biol
; 12(2): 144-51, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15665873
11.
Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.
Biochemistry
; 48(19): 4040-9, 2009 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19317456
12.
Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.
Nucleic Acids Res
; 35(1): 87-99, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17151076
13.
Rna14-Rna15 assembly mediates the RNA-binding capability of Saccharomyces cerevisiae cleavage factor IA.
Nucleic Acids Res
; 32(11): 3364-75, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15215336
14.
Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J Med Chem
; 59(8): 3935-52, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26984786
15.
The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism.
J Mol Biol
; 318(2): 361-71, 2002 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12051843
16.
The dengue virus NS5 protein as a target for drug discovery.
Antiviral Res
; 119: 57-67, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25912817
17.
Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.
Eur J Med Chem
; 106: 144-56, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26544629
18.
Direct inhibitors of InhA are active against Mycobacterium tuberculosis.
Sci Transl Med
; 7(269): 269ra3, 2015 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25568071
19.
Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine.
Antiviral Res
; 111: 78-81, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25241250
20.
Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus.
Virology
; 450-451: 250-7, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24503088