Detalhe da pesquisa
1.
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg Med Chem Lett
; 26(24): 5926-5930, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27876318
2.
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Bioorg Med Chem Lett
; 26(13): 3202-3206, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080178
3.
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
PLoS One
; 17(12): e0271145, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36477212
4.
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
ACS Med Chem Lett
; 11(3): 358-364, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184970
5.
A new silicon lewis acid for highly enantioselective mannich reactions of aliphatic ketone-derived hydrazones.
J Am Chem Soc
; 130(21): 6676-7, 2008 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18444641
6.
Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.
Biochem Pharmacol
; 151: 282-290, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29408488
7.
ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J Clin Invest
; 128(10): 4485-4500, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30024858
8.
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
J Med Chem
; 59(19): 9005-9017, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690427
9.
Highly enantioselective Mannich reactions with α-aryl silyl ketene acetals and imines.
Org Lett
; 13(4): 816-8, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21235253
10.
Kinetic resolution of protected alpha-amino acid derivatives by a chiral O-nucleophilic acyl transfer catalyst.
J Am Chem Soc
; 128(13): 4230-1, 2006 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16568989
11.
Kinetic resolution of alpha-acetoxy N-acyl oxazolidinethiones by a chiral O-nucleophilic acyl transfer catalyst.
J Am Chem Soc
; 127(39): 13502-3, 2005 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190706