Detalhe da pesquisa
1.
Absorption, metabolism and excretion of 14C-emvododstat following repeat daily oral dose administration in human volunteers using a combination of microtracer radioactivity and high radioactivity doses.
Drug Metab Dispos
; 2023 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37852795
2.
A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor.
Eur J Clin Pharmacol
; 79(8): 1073-1080, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37278823
3.
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor.
Xenobiotica
; 52(2): 152-164, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34846990
4.
Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients.
Clin Pharmacol Ther
; 115(3): 525-534, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38065572
5.
Phase Ib Study of Unesbulin (PTC596) Plus Dacarbazine for the Treatment of Locally Recurrent, Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma.
J Clin Oncol
; : JCO2301684, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38684039
6.
A pharmacokinetic drug-drug interaction study between rosuvastatin and emvododstat, a potent anti-SARS-CoV-2 (COVID-19) DHODH (dihydroorotate dehydrogenase) inhibitor.
Pharmacol Res Perspect
; 11(2): e01076, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36938928
7.
Pharmacokinetics of Dacarbazine and Unesbulin and CYP1A2-Mediated Drug Interactions in Patients With Leiomyosarcoma.
Clin Transl Sci
; 2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38129988
8.
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.
Front Oncol
; 12: 832816, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35223511
9.
Pharmacokinetics and Safety of PTC596, a Novel Tubulin-Binding Agent, in Subjects With Advanced Solid Tumors.
Clin Pharmacol Drug Dev
; 10(8): 940-949, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33440067
10.
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Mol Cancer Ther
; 20(10): 1846-1857, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34315764
11.
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Virus Res
; 292: 198246, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33249060
12.
The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines.
bioRxiv
; 2020 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32793904