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1.
Arch Orthop Trauma Surg ; 139(6): 877-881, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30972480

RESUMO

To clarify the role of concomitant carpal lesions in dislocated distal radius fractures (DRF), 104 consecutive patients with DRF underwent a preoperative morphological examination using CT and MRI. The study was performed between 2004 and 2006 with the aim of recording all types of concomitant carpal lesions as well as their consequences after 1 year. Carpal lesions of different types were found in all treated cases of dislocated DRF. A clinical follow-up 1 year (13.9 ± 6.5 months) after surgical treatment showed no correlation between the carpal lesions and the treatment outcome (previously described by Gologan et al. 2011). A second follow-up study ( > 10 years postoperative, range 11.2 ± 0.9 years) was initiated to find suspected later decompensations of the concomitant carpal lesions. A total of 37 of the original 104 patients could potentially be followed up: 22 patients had passed through both follow-ups and 15 could only be contacted with restrictions. 27 patients had died, 24 patients were excluded due to the presence of dementia or explicit rejection, and 16 patients could no longer be found. Using the Castaing score, the first follow-up after 1 year resulted in an average of 4.95 ± 3.1 points (range 0-12; "good result") and the second follow-up after 10 years in an average of 5.91 ± 2.9 points (range 2-14; "good result"). Again, there were no correlations with the primarily recognized carpal lesions [comparable groups 22 vs 22 (identical patients in both follow-ups); lost to follow-up rate 15.4%]. These results suggest that concomitant carpal lesions are primarily prevalent and detectable in (nearly) all dislocated DRF cases. However, with the usual protection of the wrist and the carpus after surgical treatment of DRF, these lesions often do not decompensate or require treatment, even after 10 years.


Assuntos
Ossos do Carpo , Luxações Articulares , Fraturas do Rádio , Ossos do Carpo/diagnóstico por imagem , Ossos do Carpo/cirurgia , Seguimentos , Humanos , Luxações Articulares/diagnóstico por imagem , Luxações Articulares/cirurgia , Imageamento por Ressonância Magnética , Fraturas do Rádio/diagnóstico por imagem , Fraturas do Rádio/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
2.
Orthopade ; 46(11): 969-978, 2017 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-28812121

RESUMO

The scramble for available places to study medicine in Germany continues. One of the core points within the "Master Plan 2020", which has been recently adopted, is the reform of teaching concepts at German medical faculties. In the future, students of human medicine are to be trained primarily based upon competence-oriented, integrated curricula. The present paper is intended to present modern teaching concepts and methods, as well as current examination formats, which play a special role in student training in orthopaedics and traumatology. Knowledge in the field of medical and evidence-based treatment strategies, clinical examination techniques, diagnostic/therapeutic procedures and hygienic working conditions are especially important. Individual courses with a focus on research-, practice- and competence-orientation are intended to help the students grasp the depth of the subject.


Assuntos
Docentes de Medicina , Ortopedia/educação , Ensino , Ferimentos e Lesões/cirurgia , Competência Clínica , Educação Baseada em Competências , Currículo , Avaliação Educacional , Medicina Baseada em Evidências , Alemanha , Humanos , Modelos Educacionais
3.
Zentralbl Chir ; 142(1): 61-66, 2017 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-26451960

RESUMO

Background: Since 2006 the practical year in the Mannheim Reformed Curriculum Medicine (MaReCuM) is divided into four quarters: the two required subjects (surgery and internal medicine), one elective and one of four offered fields in ambulatory medicine. Therefore students can more intensively focus on their preferences in the practical year. In the present article we describe the provided surgical training sites, the organisation of the practical year, the surgical training itself and the quality management. We provide answers to the following questions: does dividing the practical year into quarters have a (negative) influence on the grades of final exams; how interested, motivated and satisfied are students in the different (surgical) quarters of the practical year and in which quarter(s) can new generation staff be recruited? Methods: We used results of the final exams of three cohorts of the traditional Mannheim track and three cohorts of MaReCuM, as well as the results of the Mannheim Questionnaire of Satisfaction with Training Conditions in the Practical Year of Medical Education from the regular evaluation of three practical year cohorts within two years. Conclusions: Dividing the practical year into quarters is possible and can be organised together with the new "mandatory subject" ambulatory medicine. The introduction of quarters has no negative effects on the results of final exams. The assignment in the surgical field from students' perspectives with regard to motivation, interest, knowledge and satisfaction with training is comparable to surgical electives. Therefore recruitment of new staff is possible either in the surgical elective or in the surgical area of ambulatory medicine.


Assuntos
Currículo , Cirurgia Geral/educação , Modelos Educacionais , Preceptoria/organização & administração , Adulto , Atitude do Pessoal de Saúde , Estudos de Coortes , Avaliação Educacional , Feminino , Alemanha , Humanos , Masculino , Garantia da Qualidade dos Cuidados de Saúde/organização & administração , Estudantes de Medicina/psicologia , Procedimentos Cirúrgicos Operatórios/educação
4.
Arch Orthop Trauma Surg ; 136(3): 425-32, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26620044

RESUMO

INTRODUCTION: Ligamentous lesions are concomitant to dislocated distal radius fractures in a high percentage. The purpose of this study was to evaluate the relevance of intracarpal lesions. METHODS: Seventy eight of an original cohort of 104 distal radius fractures (74%) were studied over a follow-up period of one year after surgery with complete data (X-rays, CT, MRI, follow-up X-rays and questionnaire). RESULTS: Most of our radius fractures (AO 23 type: A 39, B 9, C 30) present additional lesions: 97%. One-year evaluation showed an average Castaing score of 4.5 ± 2.5 points, means a "good" result of a scale of 0-27. Fifty five of seventy eight had an "excellent" or "good" result (<6 points). No patient had more than 12 points ("fair"). CONCLUSIONS: The dislocated distal radial fracture implies severe and complex injury to the whole wrist, mostly concerning intracarpal concomitant lesions (MRI). Surgical therapy of dislocated radius fractures followed by 6 weeks relief through thermoplastic splint seems to be sufficient to achieve good 1-year results. MRI-detectable carpal lesions at the time of the radial fracture are common, but only a few of them seem to decompensate later, give symptoms and became of therapeutic relevance.


Assuntos
Ossos do Carpo/diagnóstico por imagem , Luxações Articulares/cirurgia , Ligamentos/diagnóstico por imagem , Fraturas do Rádio/cirurgia , Traumatismos do Punho/diagnóstico , Articulação do Punho/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Ossos do Carpo/patologia , Estudos de Coortes , Feminino , Humanos , Luxações Articulares/complicações , Luxações Articulares/diagnóstico , Ligamentos/patologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Fraturas do Rádio/complicações , Fraturas do Rádio/diagnóstico , Amplitude de Movimento Articular , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Traumatismos do Punho/complicações , Articulação do Punho/patologia , Adulto Jovem
5.
Radiologe ; 55(10): 859-67, 2015 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-26420600

RESUMO

BACKGROUND: Due to a more effective systemic therapy the survival of patients suffering from malignant tumors has been significantly improved but a longer life span is often associated with a higher incidence of osseous metastases. The majority of these metastases are localized in the spine causing pain, instability and neurological impairments. The interdisciplinary management of spinal metastases previously consisted of stabilization followed by fractionated external body radiation therapy. A reduction in procedural severity and morbidity as well as consideration of self-sufficiency and hospitalization time are important target parameters for these palliative patients. METHOD AND RESULTS: Kyphoplasty combined with intraoperative radiotherapy (Kypho-IORT) is one of several modern treatment options, which involves a minimally invasive procedure with local high-dose transpedicular irradiation of the spine with low-energy (50 kV) X-rays. Immediately following irradiation, stabilization of the spine is carried out using kyphoplasty via the same access route so that a single stage procedure with excellent pain reduction and good local tumor control can be achieved. This article presents clinical data for this procedure and the different fields of indications are critically reviewed and compared to other therapy options. Methodological improvements and options for further individualization of therapy are demonstrated. CONCLUSION: The Kypho-IORT procedure is a safe, feasible and beneficial modern treatment option for instant stabilization and local tumor control in patients with spinal metastases. More than 100 operations have been successfully performed so that the method can be deemed suitable for inclusion in the clinical routine. A phase II dose escalation study has now been completed and submitted for publication and a 2-arm non-inferiority trial (phase III study) for comparison with conventional irradiation is in progress.


Assuntos
Dor nas Costas/prevenção & controle , Cifoplastia/métodos , Recidiva Local de Neoplasia/prevenção & controle , Radioterapia Adjuvante/métodos , Neoplasias da Coluna Vertebral/secundário , Neoplasias da Coluna Vertebral/terapia , Dor nas Costas/etiologia , Terapia Combinada/métodos , Humanos , Cuidados Intraoperatórios/métodos , Neoplasias da Coluna Vertebral/complicações , Resultado do Tratamento
6.
Unfallchirurg ; 117(6): 528-32, 2014 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-23736970

RESUMO

BACKGROUND: Injuries due to domestic violence are a frequent occurrence in emergency departments. Although domestic violence has been well analyzed from the sociological point of view, medical data concerning patterns of injuries are rare. METHODS: Victims of domestic violence who presented at the emergency department of a maximum care hospital were included in the study. Sociodemographic data and patterns of injuries were documented. RESULTS: Of the patients who presented at the emergency room 1.4 % suffered injuries due to domestic violence and 70 % were women who had been predominantly attacked by the (ex) partner. The male victims were predominantly attacked by friends. In 88 % the head and neck were involved. Male patients were attacked with objects (as a kind of weapon) more frequently than women. A migration background was documented in 45 % of the female and 30 % of the male patients. CONCLUSION: Patterns can be easily recognized: the victims were predominantly female and were attacked by the (ex) partner. Injuries were localized to the upper part of the body. No excessive violence with life-threatening or fatal injuries was observed.


Assuntos
Centros Médicos Acadêmicos/estatística & dados numéricos , Violência Doméstica/estatística & dados numéricos , Serviço Hospitalar de Emergência/estatística & dados numéricos , Emigrantes e Imigrantes/estatística & dados numéricos , Cônjuges/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Escolaridade , Emprego/estatística & dados numéricos , Feminino , Alemanha/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Distribuição por Sexo , Fatores Socioeconômicos , Adulto Jovem
7.
Unfallchirurg ; 117(1): 48-53, 2014 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-23052706

RESUMO

BACKGROUND: The functional outcome of surgically treated dislocated fractures of the distal radius is limited and does not correlate with radiographic results. Additional carpal lesions are assumed to be the cause. This study has evaluated which carpal lesions are associated with dislocated fractures of the distal radius. MATERIAL AND METHODS: A total of 104 consecutive patients with dislocated fractures of the distal radius were included in the study. The injured wrist was examined by radiography, computed tomography (CT) and magnetic resonance imaging (MRI) to determine additional carpal lesions. RESULTS: Radiographically 51 of the 104 fractures presented as type A according to the AO classification, 10 as type B and 39 as type C. The CT scan detected that only 5 of the 51 type A fractures were exclusively metaphyseal fractures. All type A fractures were associated with ligamental lesions in MRI. CONCLUSIONS: The results of the study confirm the hypothesis that every dislocated fracture of the distal radius is a combined carpal trauma associated with additional osseous and/or ligamental lesions.


Assuntos
Ossos do Carpo/lesões , Fraturas Mal-Unidas/diagnóstico , Imageamento por Ressonância Magnética/métodos , Traumatismo Múltiplo/diagnóstico , Fraturas do Rádio/diagnóstico , Tomografia Computadorizada por Raios X/métodos , Traumatismos do Punho/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Ossos do Carpo/patologia , Ossos do Carpo/cirurgia , Feminino , Consolidação da Fratura , Fraturas Mal-Unidas/cirurgia , Humanos , Masculino , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Traumatismo Múltiplo/cirurgia , Cuidados Pré-Operatórios/métodos , Fraturas do Rádio/cirurgia , Recuperação de Função Fisiológica , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Traumatismos do Punho/cirurgia , Adulto Jovem
8.
Orthopade ; 42(9): 772-9, 2013 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-23989594

RESUMO

The Kypho-IORT procedure is a recently developed surgical technique to combine intraoperative radiotherapy with cement augmentation of the vertebra for spinal metastases. The technical feasibility and the operation principle of this new method have been described. In the following article the refinement of the standard operation procedure and the technical development of the method are described. Not only the procedural improvements but also the learning curves of the inaugurators are pointed out. Moreover, the article presents the measures which were necessary to educate trainees during surgical master classes in this new method and to transfer the method. The learning success was quantified by recording the accuracy reached by the trainees in the key procedure during hands-on cadaver exercises. Improvements of the standard operation procedure could be successfully transferred in a second master class. The method of Kypho-IORT and the demonstrated way of postgraduate education is feasible to instruct trainees. The Kypho-IORT procedure can be learnt and performed safely by running through the surgical master class.


Assuntos
Educação Médica Continuada/métodos , Cifoplastia/educação , Laminectomia/educação , Competência Profissional , Radioterapia Conformacional/métodos , Fusão Vertebral/educação , Neoplasias da Coluna Vertebral/terapia , Cadáver , Terapia Combinada/métodos , Avaliação Educacional , Alemanha , Humanos , Cifoplastia/métodos , Laminectomia/métodos , Fusão Vertebral/métodos , Resultado do Tratamento
9.
Orthopade ; 42(9): 765-71, 2013 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-23887850

RESUMO

BACKGROUND: Operative and radiotherapeutic procedures are available for the treatment of symptomatic vertebral metastases. The method for treatment of vertebral metastases presented in this article involves a combination of intraoperative radiotherapy (IORT) and kyphoplasty. METHODS AND RESULTS: Kyphoplasty-IORT allows treatment of symptomatic vertebral metastases between vertebrae T3 and L5. With the patient under intubation narcosis an extrapedicular or bipedicular access to the vertebra is selected as for conventional kyphoplasty. This is followed by insertion of special sheaths of the radiation applicator and radiation therapy is intraoperatively administered via a radiation generator (Intrabeam®, Carl Zeiss Surgical, Oberkochen, Germany). The radiation dose is 8 Gy at a depth of 5-10 mm depending on the study protocol (50 kV X-radiation). Following radiation a conventional kyphoplasty procedure (Medtronic, USA) is carried out and the vertebra stabilized with cement. CONCLUSIONS: The procedure presented demonstrates a new approach to treatment of vertebral metastases and represents a valuable alternative to previously established methods.


Assuntos
Cifoplastia/métodos , Laminectomia/métodos , Radioterapia Conformacional/métodos , Neoplasias da Coluna Vertebral/secundário , Neoplasias da Coluna Vertebral/terapia , Algoritmos , Terapia Combinada/métodos , Humanos , Neoplasias da Coluna Vertebral/diagnóstico , Resultado do Tratamento
10.
Unfallchirurg ; 116(10): 884-91, 2013 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-24097239

RESUMO

Patient safety in hospitals is difficult to define and is not measurable by operational safety parameters as in other fields. So-called adverse events (AE) are a collective of complications, failures, mistakes, errors and violations. Estimations of at least 9.2 % AEs in surgery with 0.1 % fatalities are given worldwide but there are no correlations between objective quantification of AEs and subjective or public perception of safety during the perioperative period. Patient safety during this period is mostly endangered by wound infections (safety 98 %) and nosocomial infections (safety 97 %). In spite of these facts, safety parameters for problems in anesthesia, blood transfusion, in retaining surgical instruments and so-called index events, such as patient and side identification errors are much higher. Patient safety is maintained in hospitals by objective means (surgical). Checklists have been proven to improve safety and critical incidence reporting, training and changing of attitudes could have further advantages but they are difficult to measure.


Assuntos
Lista de Checagem/métodos , Administração Hospitalar/métodos , Erros Médicos/prevenção & controle , Cultura Organizacional , Segurança do Paciente , Gestão de Riscos/organização & administração , Gestão da Segurança/organização & administração , Atitude do Pessoal de Saúde , Alemanha
12.
Eur Spine J ; 19(9): 1534-9, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20490873

RESUMO

The concept of total lumbar disc replacement (TDR) is gaining acceptance due to good clinical short-term outcome. Standard implantation is strict anterior, which poses especially above the segment L5/S1 sometimes difficulties due to the vessel configuration. Therefore, oblique implantable TDR have been invented. In oblique implantation the anterior longitudinal ligament (ALL) is only partially resected, with additional partial resection of lateral annulus fibers. This could have an impact on biomechanical properties, which has not been evaluated until now. We therefore compared the standing ap and lateral X-rays pre- and postoperative after anterior and oblique implantation of TDR in segment L4/5. Significant differences between the groups were not found. In both the anterior and oblique group, segmental lordosis showed a significant increase, whereas total lordosis as well as ap balance were unchanged. The absolute segmental lordosis increase was nearly double in the anterior group. In conclusion, both anterior and oblique implanted TDR significantly increase segmental lordosis while retaining total lordosis and ap balance. The segmental increase is lower in the oblique implanted group which is probably due to the remaining ALL. Further studies should evaluate whether this finding has any implication for the long-term outcome.


Assuntos
Artroplastia de Substituição/métodos , Disco Intervertebral/cirurgia , Vértebras Lombares/cirurgia , Adulto , Feminino , Humanos , Degeneração do Disco Intervertebral/cirurgia , Prótese Articular , Masculino , Postura , Estudos Retrospectivos
13.
Unfallchirurg ; 113(1): 69-74, 2010 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-19998019

RESUMO

Non-pathologic fractures of the neck of the femur in younger patients aged between 15 and 50 years old are rare injuries. These are so-called effectual injuries with very high energy induction due to traffic accidents, falls and sport accidents, causing healthy bones to be fractured and often leading to multiple injuries. The short-term and long-term complications of such injuries sometimes give rise to substantial problems, in particular from non-union fractures and avascular necrosis of the head of the femur. In the literature (and from some experts) the impression is occasionally given that there might be "proven" successful therapeutic procedures for the methods and in particular the timing of treatment of fractures of the neck of the femur in younger patients. This presentation has gone so far that in some cases the term "treatment malpractice" has been used in legal disputes (and judgments) (Judgment IU 5146/00, Higher Regional Court Munich; 2O 861/07 Hei, Regional District Court Ansbach; 118C 421/05, District Court Cologne). The authors have often been called upon as medical experts to comment on the current state of medical knowledge on the question of the biology of healing of fractures of the neck of the femur and the question of"verified" therapy strategies. With this in mind this article is designed to give a review of the current state of proven knowledge according to the available clinical and experimental data and last but not least to stimulate constructive discussion.


Assuntos
Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/terapia , Consolidação da Fratura , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Resultado do Tratamento , Adulto Jovem
14.
Zentralbl Chir ; 135(1): 18-24, 2010 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-20162500

RESUMO

The shortage of surgeons in the operative disciplines field has in recent years further increased. The training of a surgeon and the required lifestyle combined with the work-life balance of the surgeons are perceived as being less attractive, so that young doctors after finishing medical school rarely decide for surgical careers. Changes in the social environment outside of our clinics has resulted in a decline of the social prestige. The modified structural preconditions require a rethinking of the training processes for studying and working conditions in surgery. The quality of surgical education is therefore a cornerstone for the future development of our subject and is directly linked to the training and junior development. The CAQ meeting in Greifswald in February 2009, has focused on the teaching in surgery and developed together with medical students of different faculties solutions for the three major problem factors: teaching, training and junior development. The students are demanding clear guidelines regarding the required theoretical and practical knowledge in the form of catalogues or learning logs. The absence of intrinsic commitment to an excellent teaching and role model is due to the ongoing conflict between patient care and teaching. Because in teaching usually neither the quantity nor the quality will be systematically registered and no sanctions promote the lesson, so that the training is always considered as a last resort. One approach could be a scoring system for teaching that reflect the quantity and quality of teaching in points. The practical year needs to be reformed, since over 25% of the students spend their surgery part abroad, because they are afraid to be considered as cheap labour. Especially at this point, the lecturer is asked to reform the education of students during the practical year and to strengthen the role model for young academic teachers.


Assuntos
Educação de Pós-Graduação em Medicina/normas , Cirurgia Geral/educação , Assistentes Médicos/educação , Garantia da Qualidade dos Cuidados de Saúde/normas , Escolha da Profissão , Currículo/normas , Alemanha , Humanos
15.
GMS J Med Educ ; 36(5): Doc55, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31815165

RESUMO

Introduction: To reflect the ever-growing importance of outpatient care in medical education, MaReCuM - a reformed curriculum, also referred to as a model study programme - was introduced at the Medical Faculty Mannheim in 2006. It divided the final year of medical study into quarters and added a mandatory quarter dedicated to ambulatory medicine. This project report presents our experiences, the costs and the evaluation results connected with making specific changes to the final year of undergraduate medical study. Project description: The final-year quarter in ambulatory medicine, taught at the Medical Faculty's outpatient teaching placements, allows final-year medical students to gather practical experience in one of four elective areas in outpatient care. The parallel coursework encompasses interactive case presentations and practical reviews. Relevant curricular content on ambulatory medicine is then tested in the oral/practical section of the M3 medical examination. Results: Students are very satisfied with the academic quality of the final-year quarter in ambulatory medicine. Restructuring the final year, generating the concept and recruiting teaching placements at outpatient facilities required additional full-time positions in the beginning. Discussion: The processes of reforming MaReCuM have not only contributed to a stronger recognition of ambulatory medicine in the final year and in the clinical phase of study, but have also enabled broader opportunities for focussing individual choices during medical education. A high caliber of academics in the quarter in ambulatory medicine can be achieved with a calculable amount of organisational effort. Conclusion: Anchoring a curriculum on ambulatory medicine in medical education is possible through restructuring the final year and is received positively by students. The success of MaReCuM demonstrates the feasibility of the recommendations made by the German Council of Science and Humanities (Wissenschaftsrat).


Assuntos
Assistência Ambulatorial/métodos , Avaliação de Programas e Projetos de Saúde/métodos , Currículo/normas , Currículo/tendências , Educação de Graduação em Medicina/métodos , Educação de Graduação em Medicina/normas , Alemanha , Humanos , Avaliação de Programas e Projetos de Saúde/estatística & dados numéricos , Estudantes de Medicina/psicologia , Estudantes de Medicina/estatística & dados numéricos
16.
Physiol Res ; 56(2): 227-233, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-16555940

RESUMO

Metabolic consequences of direct muscle trauma are insufficiently defined. Their effects on the ubiquitin-proteasome pathway (UPP) of protein degradation in human skeletal muscles are as yet unknown. Thus, we investigated whether the UPP is involved in the metabolic response evoked in directly traumatized human skeletal muscles. Biopsies were obtained from contused muscles after fractures and from normal muscles during elective implant removal (control). As estimated by western blot analyses, concentrations of free ubiquitin and ubiquitin protein conjugates were similar in extracts from injured and uninjured muscles. Ubiquitin protein ligation rates were reduced after injury (1.5+/-0.2 vs. 1.0+/-0.15 fkat/microg; p=0.04). Chymotryptic-, tryptic- and caspase-like proteasome peptidase activities (total activity minus activity in the presence of proteasome inhibitors) increased significantly after trauma (p=0.04 - 0.001). Significant increases in total chymotryptic- and caspase-like activities were attributable to proteasome activation. Our results extend the possible role of the UPP in muscle wasting to direct muscle trauma. They further suggest that the effects of direct mechanical trauma are not limited to the proteasome and imply that ubiquitin protein ligase systems are also involved. Based on the potential role of the UPP in systemic diseases, it might also be a therapeutic target to influence muscle loss in critically ill blunt trauma patients, in which large proportions of muscle are exposed to direct trauma.


Assuntos
Músculo Esquelético/lesões , Músculo Esquelético/metabolismo , Atrofia Muscular/metabolismo , Complexo de Endopeptidases do Proteassoma/metabolismo , Processamento de Proteína Pós-Traducional , Ubiquitina-Proteína Ligases/metabolismo , Ubiquitina/metabolismo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Caspases/metabolismo , Quimotripsina/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/enzimologia , Atrofia Muscular/enzimologia , Fatores de Tempo , Tripsina/metabolismo
17.
Rofo ; 178(8): 801-9, 2006 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-16862507

RESUMO

PURPOSE: To evaluate the value of MDCT in the monitoring of vertebral body architecture after balloon kyphoplasty and observe morphological changes of the vertebral body. MATERIAL AND METHODS: During a period of 26 months, 66 osteoporotic fractures of the vertebral bodies were treated with percutanous balloon kyphoplasty. The height of the vertebral body, width of spinal space, sagittal indices, kyphosis und COBB angle, and cement leakage were evaluated by computed tomography before and after treatment and in a long-term follow up. Statistical analysis was performed by calculating quantitative constant parameters of descriptive key data. In addition, parametric and distribution-free procedures were performed for all questions. RESULTS: After kyphoplasty, the treated vertebral bodies showed a significant gain in the height of the leading edge (0.15 cm; p < 0.0001) and in the central part of the vertebral body (0.17 cm; p < 0.0001). The height of the trailing edge did not change significantly. A corresponding gain in the sagittal index was found. The index remained stable during follow-up. Treated vertebral bodies as well as untreated references showed a comparable loss of height over the period of one year. The shape of the vertebral bodies remained stable. In comparison to these findings, treated vertebral bodies showed a reduced loss of height. A significant change in kyphosis und the COBB angle was noted. In total, pallacos leakage was detected in 71 % of cases. CONCLUSION: MDCT is an accurate method for evaluating vertebral body architecture after treatment with balloon kyphoplasty. Morphological changes in the vertebral bodies, and complications such as pallacos leakage and progression of osteoprosis can be accurately documented. The significant increase in the vertebral body height after treatment is closely correlated with a gain in the sagittal index and reduced kyphosis and COBB angle.


Assuntos
Cateterismo/métodos , Descompressão Cirúrgica/métodos , Laminectomia/métodos , Osteoporose/diagnóstico por imagem , Fraturas da Coluna Vertebral/diagnóstico por imagem , Coluna Vertebral/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Fraturas Espontâneas/diagnóstico por imagem , Fraturas Espontâneas/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Osteoporose/complicações , Prognóstico , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Fraturas da Coluna Vertebral/etiologia , Tomografia Computadorizada por Raios X/instrumentação , Resultado do Tratamento
18.
Z Orthop Unfall ; 154(4): 352-8, 2016 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-27294478

RESUMO

INTRODUCTION: The general shortage of medical doctors in Germany can also be felt in the area of trauma and orthopaedics. Medical elective placements, in Germany known as "Famulatur", are sensitive interfaces between the theoretical university studies and the practical medical workplace. In this research project, the aim was to study how medical students perceive these types of placements and if it alters their decision making when planning their further career. METHODS: During the summer term of 2012, 9079 medical students answered an online questionnaire. Of these, the subgroup was evaluated that had had a placement of at least 4 weeks in the field of trauma and orthopaedics. Overall, 37 test items about this placement and further career steps were included in this study. Groups were evaluated separately by the item "I am considering a career in trauma and orthopaedics" (PJ-Ja) versus "I am not considering a career in trauma and orthopaedics" (PJ-Nein). RESULTS: Overall 397 students were included in this study; 55 % were female. 267 (67.3 %) stated: "I am considering a career in trauma and orthopaedics"; 130 (32.7 %) were not. There was no significant difference in age or sex between these groups (sex: χ²= 2.50, p = 0.114; age: F[1.93]< 1, p = 0.764). Specific and statistically significant differences between those groups were found in the items team integration, ward climate, qualification of teaching, training for specific knowledge in the field, practical aspects of the tasks performed, general planning and structure of the elective achievement of the teaching goals. DISCUSSION: Knowledge of satisfaction during medical elective placements is essential if one aims to inspire students for a specific medical profession. Instructors who can identify weaknesses and deficits in their training regime can therefore in the future increase the number of medical doctors who choose their speciality. The foundation of personal development has to be laid very early in the career of medical students.


Assuntos
Escolha da Profissão , Internato e Residência/estatística & dados numéricos , Satisfação no Emprego , Ortopedia , Estudantes de Medicina/estatística & dados numéricos , Traumatologia , Adulto , Feminino , Alemanha , Humanos , Masculino , Ortopedia/educação , Traumatologia/educação , Recursos Humanos , Adulto Jovem
19.
Rofo ; 177(12): 1641-8, 2005 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-16333786

RESUMO

PURPOSE: The goal of this retrospective study was to evaluate the spectrum of abdominal injuries and the reliability of computed tomography-based diagnosis in patients after polytrauma. MATERIAL AND METHODS: CT findings and clinical reports for 177 patients after polytrauma were evaluated with regard to abdominal injuries. Clinical patient reports at the time of discharge from the hospital were utilized as the standard of reference. Abdominal injuries resulting from an accident, frequent additional traumas and following therapeutic procedures were recorded. In the case of discrepancies in the reports, the CT scans were viewed retrospectively. RESULTS: In 30 out of 177 patients, 42 abdominal injuries were detected. 69 % of the injuries were caused by traffic accidents while 31 % resulted from falls. Liver and spleen injuries were the most common. 50 % of the cases were treated surgically, and the other half of the cases underwent non-surgical conservative therapy. Massive chest traumas, pelvic injuries, cerebral traumas and injuries to extremities were commonly associated with abdominal injuries. Evaluation of the discrepancies in the clinical reports showed that injury to the pancreas and the small intestine were not successfully detected on CT, thus resulting in a false negative diagnosis. Early stages of organ parenchyma laceration were also initially misdiagnosed on CT. CONCLUSION: Contrast-enhanced whole-body MSCT is a reliable and rapid method for diagnosing abdominal injuries in patients after polytrauma. Only very few patterns of injury are not detected on CT. The appearance of fluid collection in the abdomen is an indicator of possible parenchyma injury and requires further evaluation in cases of clinically suspected organ trauma.


Assuntos
Traumatismos Abdominais/diagnóstico por imagem , Traumatismo Múltiplo/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Traumatismos Abdominais/etiologia , Acidentes por Quedas , Acidentes de Trânsito , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Meios de Contraste , Emergências , Feminino , Humanos , Iohexol/análogos & derivados , Fígado/lesões , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/etiologia , Padrões de Referência , Estudos Retrospectivos , Sensibilidade e Especificidade , Baço/lesões
20.
J Hosp Infect ; 89(3): 210-4, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25623207

RESUMO

BACKGROUND: Although the need for hand hygiene (HH) is generally accepted, studies continue to document inadequate compliance. Medical students are taught about the importance of HH to prevent nosocomial infections, and receive training in the correct procedures for HH. However, personality traits (social orientation and achievement orientation) may influence HH compliance. People with high social orientation feel socially responsible and act cooperatively, and people with high achievement orientation are ambitious and competitive. AIM: To evaluate the relationship between HH compliance and personality traits of medical students. METHODS: The HH compliance of 155 students was observed during objective standardized clinical examinations (OSCEs). Social orientation and achievement orientation were measured using the corresponding scales of the Freiburg Personality Inventory - Revised. FINDINGS: Social orientation did not differ between students with high HH compliance and students with low HH compliance [F(1) = 3.87, P = 0.052, η(2) = 0.045]. For achievement orientation, a moderate effect was found between low and high HH compliance [F(1) = 11.242, P = 0.001, η(2) = 0.119], and students with high HH compliance were found to be more achievement orientated than students with low HH compliance. CONCLUSION: Achievement orientation plays a major role during OSCEs, while social orientation is less emphasized. To the authors' knowledge, this is the first study to show that HH compliance is associated with achievement orientation in achievement situations.


Assuntos
Complacência (Medida de Distensibilidade) , Desinfecção das Mãos , Personalidade , Exame Físico/métodos , Estudantes de Medicina/psicologia , Estudos de Coortes , Infecção Hospitalar/prevenção & controle , Feminino , Alemanha , Fidelidade a Diretrizes , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Exame Físico/normas
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