Detalhe da pesquisa
1.
Neonatal gastrointestinal perforation in Japan: a nationwide survey.
Pediatr Surg Int
; 33(1): 33-41, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27696212
2.
Is human chorionic gonadotropin supplementation beneficial for frozen and thawed embryo transfer in estrogen/progesterone replacement cycles?: A randomized clinical trial.
Reprod Med Biol
; 16(2): 166-169, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29259465
3.
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
J Virol
; 90(5): 2180-94, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26581995
4.
A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.
Antimicrob Agents Chemother
; 58(7): 3679-88, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752271
5.
Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1.
J Virol
; 86(24): 13384-96, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015723
6.
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Sci Adv
; 9(28): eadg2955, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436982
7.
Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.
J Virol
; 85(19): 10079-89, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813613
8.
Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors.
J Virol
; 83(7): 3059-68, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176623
9.
Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats.
Sci Rep
; 10(1): 4913, 2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32188928
10.
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
Sci Rep
; 10(1): 10664, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606378
11.
Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity.
Oncotarget
; 9(17): 13884-13893, 2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29568402
12.
Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.
mBio
; 9(2)2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29511083
13.
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
Elife
; 62017 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29039736
14.
Anti-EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half-life.
FEBS Open Bio
; 6(6): 594-602, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27419062
15.
The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection.
Curr Opin Pharmacol
; 4(5): 447-52, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15351348
16.
Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure.
J Clin Diagn Res
; 9(11): QC14-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26674361
17.
Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics.
MAbs
; 6(5): 1243-54, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25517309
18.
Multimerization of anti-(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers.
FEBS J
; 280(19): 4816-26, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23890417
19.
Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody.
Protein Eng Des Sel
; 26(5): 359-67, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23468569
20.
In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody.
Oncol Rep
; 26(4): 949-55, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21743971