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1.
J Korean Med Sci ; 27(7): 788-93, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22787376

RESUMO

This study represents the first epidemiological study based on the national registry of primary immunodeficiencies (PID) in Korea. Patient data were collected from 23 major hospitals. A total of 152 patients with PID (under 19 yr of age), who were observed from 2001 to 2005, have been entered in this registry. The period prevalence of PID in Korea in 2005 is 11.25 per million children. The following frequencies were found: antibody deficiencies, 53.3% (n = 81), phagocytic disorders, 28.9% (n = 44); combined immunodeficiencies, 13.2% (n = 20); and T cell deficiencies, 4.6% (n = 7). Congenital agammaglobulinemia (n = 21) and selective IgA deficiency (n = 21) were the most frequently reported antibody deficiency. Other reported deficiencies were common variable immunodeficiencies (n = 16), X-linked agammaglobulinemia (n = 15), IgG subclass deficiency (n = 4). Phagocytic disorder was mostly chronic granulomatous disease. A small number of patients with Wiskott-Aldrich syndrome, hyper-IgE syndrome, and severe combined immunodeficiency were also registered. Overall, the most common first manifestation was pneumonia. This study provides data that permit a more accurate estimation PID patients in Korea.


Assuntos
Síndromes de Imunodeficiência/epidemiologia , Adolescente , Agamaglobulinemia/congênito , Agamaglobulinemia/epidemiologia , Distribuição por Idade , Criança , Pré-Escolar , Imunodeficiência de Variável Comum/epidemiologia , Feminino , Doenças Genéticas Ligadas ao Cromossomo X/epidemiologia , Humanos , Deficiência de IgA/epidemiologia , Deficiência de IgG/epidemiologia , Lactente , Recém-Nascido , Síndrome de Job/epidemiologia , Masculino , Prevalência , Sistema de Registros , República da Coreia/epidemiologia , Imunodeficiência Combinada Severa/epidemiologia , Distribuição por Sexo , Inquéritos e Questionários , Síndrome de Wiskott-Aldrich/epidemiologia , Adulto Jovem
2.
Allergy Asthma Immunol Res ; 11(2): 222-230, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30661314

RESUMO

PURPOSE: Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide. METHODS: Twenty healthcare facilities (secondary or tertiary hospitals) belonging to the Korean Academy of Pediatric Allergy and Respiratory Diseases (KAPARD) participated. Questionnaires were given to patients currently receiving treatment in the form of inhalant useor oral intake or transdermal patch for mild to moderate asthma. RESULTS: A total of 1,838 patients responded to the questionnaire. Mean age was 5.98 ± 3.79 years (range: 0-18 years). With help from their caregivers, the percentage of patients that answered "taking as prescribed" was 38.04% for inhalant users, 50.09% for oral medication users and 67.42% for transdermal users. Transdermal patch users had significantly greater adherence compared to the other 2 groups (P < 0.001). The 34.15% of inhalant users, 70.33% of oral medication users and 93.00% of transdermal patch users felt that their medication delivery system was "Easy" or "Very easy" to use (P < 0.001). "Method of administration" was deemed to be the most difficult part of the treatment regimen to follow, and 76.7% of patients preferred once-daily administration (i.e., "Frequency of administration"). CONCLUSIONS: Asthma medication adherence in young children was found to be better in the transdermal patch group. This may be due to requiring fewer doses and easy to follow instructions. From an adherence point of view, the transdermal patch seems more useful for long-term asthma control in children compared to oral or inhaled medicine.

3.
Respir Med ; 150: 8-14, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30961955

RESUMO

BACKGROUND: Bronchiectasis is a chronic pulmonary disease characterized by progressive and irreversible bronchial dilatation. The aim of the present study was to investigate the etiologies and clinical features of bronchiectasis in Korean children. METHODS: We performed a retrospective review of the medical records for children diagnosed with bronchiectasis between 2000 and 2017 at 28 secondary or tertiary hospitals in South Korea. RESULTS: A total of 387 cases were enrolled. The mean age at diagnosis was 9.2 ±â€¯5.1 years and 53.5% of the patients were boys. The most common underlying cause of bronchiectasis was preexisting respiratory infection (55.3%), post-infectious bronchiolitis obliterans (14.3%), pulmonary tuberculosis (12.3%), and heart diseases (5.6%). Common initial presenting symptoms included chronic cough (68.0%), recurrent pneumonia (36.4%), fever (31.1%), and dyspnea (19.7%). The most predominantly involved lesions were left lower lobe (53.9%), right lower lobe (47.1%) and right middle lobe (40.2%). No significant difference was observed in the distribution of these involved lesions by etiology. The forced expiratory volume in 1 s (FEV1) levels were lowest in cases with interstitial lung disease-associated bronchiectasis, followed by those with recurrent aspiration and primary immunodeficiency. CONCLUSIONS: Bronchiectasis should be strongly considered in children with chronic cough and recurrent pneumonia. Long-term follow-up studies on pediatric bronchiectasis are needed to further clarify the prognosis and reduce the disease burden in these patients.


Assuntos
Bronquiectasia/diagnóstico , Bronquiectasia/etiologia , Bronquiectasia/terapia , Pneumopatias/epidemiologia , Infecções Respiratórias/complicações , Adolescente , Bronquiectasia/fisiopatologia , Bronquiolite Obliterante/complicações , Bronquiolite Obliterante/epidemiologia , Criança , Pré-Escolar , Tosse/diagnóstico , Tosse/etiologia , Dispneia/diagnóstico , Dispneia/etiologia , Feminino , Febre/diagnóstico , Febre/etiologia , Volume Expiratório Forçado/fisiologia , Cardiopatias/complicações , Cardiopatias/epidemiologia , Humanos , Pneumopatias/patologia , Masculino , Pneumonia/diagnóstico , Pneumonia/etiologia , Prognóstico , Recidiva , República da Coreia/epidemiologia , Testes de Função Respiratória/métodos , Infecções Respiratórias/epidemiologia , Estudos Retrospectivos , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/epidemiologia
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