[Enzyme reamination of phosphororganic analogs of aspartate and glutamate]. / Fermentativnoe pereaminirovanie fosfororganicheskikh analogov aspartata i glutamata.

Phosphonous and phosphonic analogues of aspartate and glutamate are substrates of semireaction of enzymatic transamination catalysed by aspartate aminotransferase.

[Organophosphate analogs of biologically active compounds. XIV. Halophosphonate analogs of ATP as acetyl CoA carboxylase inhibitors]. / Fosfororganicheskie analogi biologicheski aktivnykh soedinenii. XIV. Galoidfosfonatnye analogi ATP kak ingibitory Ac CoA-karboksilazy.

Halophosphonate ATP analogues pp[CHBr]pA and p[CHBr]ppA synthesised from bromomethylenebisphosphonate and adenosine derivatives, proved to be effective competitive inhibitors of Ac-CoA-carboxylase (CE 6.4.1.2) from rat liver (Ki = 0,2 mM). The inhibitory effects of both analogues were reversible and higher than those of some other ATP analogues. Another enzyme, Ac-CoA-synthetase (CE 6.2.1.1), with a different mode of ATP-cleavage showed wider specificity to ATP-analogues than Ac-CoA-carboxylase.

[Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids]. / Ingibirovanie angiotenzinprevrashchaiushchego fermenta iz pochek byka fosfororganicheskimo analogami aminokislot.

Reactions of amino acid phosphoorganic derivatives with angiotensin-converting enzyme (dipeptidyl carboxypeptidase) were studied. Substitution of the amino acid carboxyl group by HS- or P(O) (OH)2-groups did not cause the enzyme considerable inhibition. The enzymatic activity was inhibited by 20-50% in presence of 1 X 10(-3) M Asp, Met and Cys phosphoorganic derivatives. These amino acid derivatives may be used as potential antihypertensive drugs because of their metabolic stability and inhibitory action on the enzyme.

[The formation of ATP from adenosine 5'-phosphoroimidazolide and pyrophosphate catalyzed by valyl-tRNA-synthetase]. / Kataliziruemoe valil-t PNK-sintetazoi obrazovanie ATP iz adenozin-5-fosfoimidazolida i pirofosfata

The formation of 32P-ATP from adenosine 5'-phosphoroimidazolide and 32P-pyrophosphate brought about valine: tRNA-ligase of E. coli is demonstrated in the standard conditions of pyrophosphate exchange for aminoacyl-tRNA synthetases. The role the enzyme as specific matrix is suggested.