RESUMO
Metastatic Crohn's disease is a rare complication of Crohn's disease that has not been frequently reported in the literature. Although Crohn's disease is common in children, cutaneous manifestations are rarely a presenting sign. We report the case of a young boy who initially presented with unusual skin lesions and whose condition was diagnosed later as Crohn's disease.
Assuntos
Doença de Crohn/patologia , Dermatopatias/patologia , Doenças do Ânus/patologia , Criança , Granuloma/patologia , Humanos , Masculino , Úlceras Orais/patologiaRESUMO
Cytomegalovirus (CMV), a member of the herpesviridae family, can cause various dermatologic and systemic disorders especially in immunosuppressed subjects. However, immunocompetent individuals rarely present with cutaneous eruptions related to CMV. We describe an immunocompetent patient who developed a skin eruption and mild hepatitis related to CMV.
Assuntos
Infecções por Citomegalovirus/complicações , Imunocompetência , Dermatopatias Vesiculobolhosas/virologia , Dermatopatias Virais/complicações , Infecções por Citomegalovirus/imunologia , Feminino , Hepatite Viral Humana/imunologia , Hepatite Viral Humana/virologia , Humanos , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase/métodos , Dermatopatias Vesiculobolhosas/imunologia , Dermatopatias Virais/imunologia , Resultado do TratamentoRESUMO
BACKGROUND: Association of psoriasis vulgaris with HLA antigens reference to age at onset has been reported in different racial or ethnic populations. OBJECTIVE: Our purpose was to determine the distribution of HLA markers in the Turkish population according to the age at onset of the psoriasis vulgaris. METHODS: HLA class I and class II antigens were performed by serologic methods in a group of 100 Turkish patients with psoriasis and 201 control subjects. Patients with psoriasis were subdivided into two groups based on age at onset (below or above 40 years of age) and family history. RESULTS: The frequency of HLA A30, Cw3, Cw6, DR7, DR14, DQ8, and DQ9 antigens were significantly increased in the Turkish psoriatic patients whereas HLA A66, Cw2, Cw4 and DR11 were found to be negatively associated with psoriasis. However, there were striking differences in HLA antigens according to the age at onset of the disease. Type I, early onset was associated with a high frequency of A30, B50, Cw6 and DR7 antigens whereas patients with type II, late onset had an increased frequency of Cw7. CONCLUSIONS: We conclude that psoriasis is probably a genetically determined disease and suggest that HLA-Cw6 antigen seems to associate commonly with early onset of psoriasis in Turkish patients.
Assuntos
Idade de Início , Predisposição Genética para Doença/genética , Antígenos de Histocompatibilidade Classe II/genética , Antígenos de Histocompatibilidade Classe I/genética , Psoríase/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Frequência do Gene/genética , Humanos , Região de Controle de Locus Gênico/genética , Masculino , Pessoa de Meia-Idade , Razão de Chances , TurquiaRESUMO
Epidermodysplasia verruciformis (EV) is an autosomal recessive disease characterized by the lifelong eruption of disseminated verrucae-like lesions. Numerous treatment modalities have been used to treat EV without benefit. Recently, retinoid and interferon therapies have been found to be of value in the treatment of EV. We present a case of EV that was treated with a combination of acitretin and interferon alfa-2a.