RESUMO
BACKGROUND: The global burden of periodontal diseases remains high. Population growth trends, changes in risk factors and improved tooth retention will increase the socio-economic burden of periodontitis that is responsible for 3.5 million years lived with disability, 54 billion USD/year in lost productivity and a major portion of the 442 billion USD/year cost for oral diseases. METHODS: In the context of the Milan World Exhibition 2015 "Feeding the Planet, Energy for Life," a green paper was developed and offered for global consultation by the European Federation of Periodontology. The final draft was endorsed by professional organizations around the world and is presented to stakeholders as a call for global action. RESULTS: Specific actions for the public, policymakers, educators and professional organizations have been identified in the areas of prevention, detection and care. These actions align public interest and knowledge, need for self-care, professional intervention and policies to the best scientific evidence to proactively promote periodontal health and effectively manage the global burden of periodontal diseases, in accordance with WHO/UN priorities and strategies for tackling common non-communicable diseases via the Common Risk Factor Approach. CONCLUSIONS: A strong and coherent body of evidence allows identification of actionable preventive, diagnostic and therapeutic strategies to effectively promote periodontal health and general wellbeing, and better manage the socio-economic consequences. Action requires consideration of the specific national scenarios.
Assuntos
Saúde Global , Política de Saúde , Doenças Periodontais/epidemiologia , Doenças Periodontais/prevenção & controle , Humanos , Estado Nutricional , Doenças Periodontais/diagnóstico , Doenças Periodontais/terapia , Fatores de Risco , Fatores SocioeconômicosRESUMO
Hormonal changes throughout the life cycle of women affect the therapeutic decision-making process of dentists. Recent research has provided an appreciation of how unique endocrine influences can affect oral, periodontal and peri-implant tissues. As endocrine status may modify periodontal and oral tissue responses to treatment, it is imperative that clinicians recognize, customize and appropriately alter periodontal therapy according to the specific hormonal stage of women.
Assuntos
Assistência Odontológica , Doenças Periodontais/prevenção & controle , Fenômenos Reprodutivos Fisiológicos , Saúde da Mulher , Feminino , Humanos , Menopausa/fisiologia , Ciclo Menstrual/fisiologia , Saúde Bucal , Medicina de Precisão , Gravidez , Puberdade/fisiologiaRESUMO
BACKGROUND: Gingivitis is a non-specific inflammatory lesion in response to the accumulation of oral biofilm and is a necessary precursor to periodontitis. Enhanced oral hygiene practices, including utilization of a dentifrice that could significantly improve plaque accumulation and gingival inflammation, is desirable to prevent and treat gingivitis and potentially prevent progression to periodontitis. This clinical study aimed to investigate the effect of a new stannous fluoride-containing dentifrice with 2.6% ethylenediamine tetra acetic acid (EDTA) as an anti-tartar agent to reduce plaque index and gingival index over a 3-month study period compared to other commercially-available fluoride-containing dentifrices. METHODS: This double-blind, randomized controlled clinical study evaluated plaque, gingival inflammation, and sulcular bleeding in patients using one of five commercially available fluoride-containing dentifrices The dentifrices tested contained: 0.454% stannous fluoride and 2.6% EDTA (D1), 0.24% sodium fluoride (C), and 0.454% stannous fluoride (D2-D4). One hundred fifty subjects participated over a 3-month period. Co-primary endpoints were improvements in plaque index (PI) and modified gingival index (mGI) from baseline values. No professional cleaning was performed during the study period. RESULTS: All subjects in the study demonstrated statistically significant improvements in all measures of oral hygiene over the 3-month study period. Subjects using dentifrice 1 (D1) showed statistically significantly greater reductions in PI, mGI, and modified sulcular bleeding index (mSBI) compared with all other commercially-available dentifrices tested (p < 0.00001). CONCLUSIONS: A new dentifrice with 0.454% stannous fluoride and 2.6% EDTA demonstrated significant improvements in clinical parameters associated with gingivitis compared to other sodium and stannous fluoride containing dentifrices.
Assuntos
Placa Dentária , Dentifrícios , Gengivite , Humanos , Fluoreto de Sódio/uso terapêutico , Dentifrícios/uso terapêutico , Fluoretos de Estanho/uso terapêutico , Fluoretos/uso terapêutico , Ácido Edético , Análise de Variância , Índice de Placa Dentária , Placa Dentária/tratamento farmacológico , Placa Dentária/prevenção & controle , Gengivite/tratamento farmacológico , Método Duplo-Cego , Inflamação/tratamento farmacológicoRESUMO
How does low bone mineral density alter treatment decisions? Osteoporosis and osteopenia are major health care issues that may impact on periodontal and implant therapy. Because of the prevalence of osteoporosis, understanding its etiology and the current treatment regimens for patients with low bone mineral density is essential for dental professionals. Millions of patients are now taking medications for the treatment of osteoporosis, and periodontists should be aware of the many medication options that are prescribed. The most frequently prescribed drugs are the bisphosphonates. It is important to be aware that bisphosphonates are not all the same, and patient responses to treatment may vary depending on which bisphosphonates they are taking. Due to recent concerns about bisphosphonate-induced osteonecrosis of the jaw, this paper provides guidance to help the clinician regarding decision-making about preventive and interventional dental treatment when their patient has been prescribed a bisphosphonate. An understanding of current bisphosphonates, their uses, their structural differences and their intended actions helps to improve clinical decision-making. Current knowledge regarding the effects of osteoporosis/osteopenia on periodontal diseases and alveolar bone loss is inconclusive. It is certainly clear that bisphosphonates are not indicated as an adjunctive treatment as part of periodontal therapy because of the risk of osteonecrosis. Regarding implant placement, there are no convincing data that dental implant placement is contraindicated in the osteoporotic patient. However, patients should understand the small risk of compromised bone healing following implant placement if the patient has been taking bisphosphonates. Due to the risks of osteonecrosis, dental clinicians should work closely with their medical colleagues prior to the physician prescribing oral bisphosphonates. Ideally, optimal periodontal and dental health should be established before the patient commences bisphosphonate therapy.
Assuntos
Doenças Ósseas Metabólicas/complicações , Implantes Dentários , Osteoporose/complicações , Doenças Periodontais/terapia , Perda do Osso Alveolar/terapia , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/prevenção & controle , Densidade Óssea/fisiologia , Conservadores da Densidade Óssea/efeitos adversos , Conservadores da Densidade Óssea/uso terapêutico , Doenças Ósseas Metabólicas/tratamento farmacológico , Tomada de Decisões , Humanos , Osteoporose/tratamento farmacológico , Doenças Periodontais/prevenção & controleRESUMO
CONTEXT: Inflammatory periodontal diseases exhibit an association with multiple systemic conditions. Currently, there is a lack of consensus among experts on the nature of these associations and confusion among health care providers and the public on how to interpret this rapidly growing body of science. This article overviews the current evidence linking periodontal diseases to diabetes, cardiovascular disease, osteoporosis, preterm low birth weight babies, respiratory diseases, and rheumatoid arthritis. EVIDENCE ACQUISITION: Evidence was taken from systematic reviews, clinical trials, and mechanistic studies retrieved in searches of the PubMed electronic database. The available data provide the basis for applied practical clinical recommendations. EVIDENCE SYNTHESIS: Evidence is summarized and critically reviewed from systematic reviews, primary clinical trials, and mechanistic studies CONCLUSIONS: Surrogate markers for chronic periodontitis, such as tooth loss, show relatively consistent but weak associations with multiple systemic conditions. Despite biological plausibility, shorter-term interventional trials have generally not supported unambiguous cause-and-effect relationships. Nevertheless, the effective treatment of periodontal infections is important to achieve oral health goals, as well as to reduce the systemic risks of chronic local inflammation and bacteremias. Inflammatory periodontal diseases exhibit an association with multiple systemic conditions. With pregnancy as a possible exception, the local and systemic effects of periodontal infections and inflammation are usually exerted for many years, typically among those who are middle-aged or older. It follows that numerous epidemiological associations linking chronic periodontitis to age-associated and biologically complex conditions such as diabetes, cardiovascular disease, osteoporosis, respiratory diseases, rheumatoid arthritis, certain cancers, erectile dysfunction, kidney disease and dementia, have been reported. In the coming years, it seems likely that additional associations will be reported, despite adjustments for known genetic, behavioral and environmental confounders. Determining cause-and-effect mechanisms is more complicated, especially in circumstances where systemic effects may be subtle. Currently, however, there is a lack of consensus among experts on the nature of these associations and confusion among health care providers and the public on how to interpret this rapidly growing body of science. This article overviews the current evidence linking periodontal diseases to diabetes, cardiovascular disease, osteoporosis, preterm/low birth weight babies, respiratory diseases, and rheumatoid arthritis.
Assuntos
Periodontite Crônica/complicações , Artrite Reumatoide/etiologia , Doenças Cardiovasculares/etiologia , Diabetes Mellitus/etiologia , Medicina Baseada em Evidências , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Osteoporose/etiologia , Gravidez , Doenças Respiratórias/etiologiaRESUMO
BACKGROUND: Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients. METHODS: This double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline. RESULTS: Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months. CONCLUSION: The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients.
Assuntos
Dentifrícios , Gengivite , Periodontite , Índice de Placa Dentária , Dentifrícios/uso terapêutico , Método Duplo-Cego , Humanos , Periodontite/tratamento farmacológico , Periodontite/prevenção & controle , Fluoretos de EstanhoRESUMO
OBJECTIVE: The objective of this study was to investigate the association between the antimicrobial and clinical efficacy of minocycline hydrochloride microspheres when used adjunctively with scaling and root planing. METHODS: 127 subjects with moderate-to-advanced chronic periodontitis were randomly assigned to receive either minocycline microspheres plus scaling and root planing (n = 62) or scaling and root planing alone (n = 65). Deoxyribose nucleic acid analysis and clinical data were obtained at baseline and 30 days after treatment. End points included changes in the mean sum of red complex bacteria, pocket depth, number of deep pockets, bleeding on probing, and clinical attachment level from baseline to day 30. Regression analysis determined the association between microbiological and clinical efficacy. RESULTS: Minocycline microspheres plus scaling and root planing reduced pocket depth, the number of deep pockets and bleeding on probing, and increased clinical attachment level significantly more than scaling and root planing alone (p < 0.05). Comparing minocycline microspheres plus scaling and root planing with scaling and root planing alone, the number needed to treat for a 2 mm pocket depth reduction difference was 6.5. Pocket depth reduction correlated significantly with a decrease in the numbers and proportions of red complex bacteria. Minocycline microspheres significantly improved all clinical parameters compared to scaling and root planing alone. CONCLUSIONS: The addition of minocycline microspheres to scaling and root planing led to a greater reduction in the proportions and numbers of red complex bacteria. The reduction in pocket depth was significantly correlated with the reduction of the proportions and numbers of red complex bacteria. Additionally, there were statistically greater improvements in all clinical parameters examined.
Assuntos
Antibacterianos/administração & dosagem , Periodontite Crônica/tratamento farmacológico , Bactérias Anaeróbias Gram-Negativas/efeitos dos fármacos , Minociclina/administração & dosagem , Administração Tópica , Análise de Variância , Anti-Infecciosos Locais/administração & dosagem , Periodontite Crônica/classificação , Periodontite Crônica/microbiologia , Terapia Combinada , DNA Bacteriano/análise , Placa Dentária/tratamento farmacológico , Placa Dentária/microbiologia , Raspagem Dentária , Sistemas de Liberação de Medicamentos , Feminino , Bactérias Anaeróbias Gram-Negativas/genética , Humanos , Estudos Longitudinais , Masculino , Microesferas , Pessoa de Meia-Idade , Índice Periodontal , Bolsa Periodontal/tratamento farmacológico , Bolsa Periodontal/microbiologia , Índice de Gravidade de Doença , Método Simples-Cego , Resultado do TratamentoRESUMO
BACKGROUND: Smoking increases the risk for periodontal disease and reduces the healing response. We examined the antimicrobial and clinical effects of scaling and root planing (SRP) with and without minocycline HCl 1 mg microspheres (MM) relative to smoking status in subjects with periodontitis. METHODS: A total of 127 subjects (46 never smokers, 44 former smokers, and 37 current smokers) with moderate to advanced periodontitis were randomized to receive MM + SRP (N = 62) or SRP alone (N = 65). Subgingival plaque samples collected at baseline and day 30 were examined for the presence of 40 periodontal bacteria by DNA probe analysis. RESULTS: MM + SRP reduced red-complex bacteria (RCB) numbers and proportions to a greater extent than SRP alone, irrespective of smoking status. RCB numbers were not reduced by SRP in current smokers. The difference in the reduction in numbers of RCB by SRP relative to MM + SRP in current smokers was statistically significant (P <0.05). Numbers and proportions of orange complex bacteria (OCB) were reduced in all groups treated with MM + SRP. Proportions of OCB increased in current smokers treated with SRP alone. In current smokers, MM + SRP significantly reduced probing depth (PD), increased clinical attachment level (CAL), and reduced bleeding on probing (BOP) to a greater extent than SRP alone (P <0.05). CONCLUSIONS: SRP alone was ineffective at reducing numbers or proportions of RCB or OCB in current smokers, whereas MM + SRP significantly reduced both. MM + SRP also improved PD, BOP, and CAL to a greater extent than SRP alone independent of smoking status.
Assuntos
Antibacterianos/administração & dosagem , Raspagem Dentária , Minociclina/administração & dosagem , Periodontite/microbiologia , Periodontite/terapia , Fumar/efeitos adversos , Análise de Variância , Bacteroides/efeitos dos fármacos , Contagem de Colônia Microbiana , Placa Dentária/microbiologia , Feminino , Humanos , Masculino , Microesferas , Pessoa de Meia-Idade , Índice Periodontal , Periodontite/etiologia , Porphyromonas gingivalis/efeitos dos fármacos , Método Simples-Cego , Treponema denticola/efeitos dos fármacosRESUMO
BACKGROUND: The objective of this trial was to measure the antimicrobial effects of a minocycline HCl microsphere (MM) local drug-delivery system when used as an adjunct to scaling and root planing (SRP). DNA probe analysis for 40 bacteria was used to evaluate the oral bacteria of 127 subjects with moderate to advanced chronic periodontitis. METHODS: Subjects were randomly assigned to either SRP alone (N = 65) or MM + SRP (N = 62). The primary endpoints of this study were changes in numbers and proportions of the red-complex bacteria (RCB) and the sum of Porphyromonas gingivalis, Tannerella forsythia (formally T. forsythensis), and Treponema denticola relative to 40 oral bacteria at each test site from baseline to day 30. Numbers of RCB from the five test sites were averaged to provide a value for each subject. RESULTS: MM + SRP reduced the proportion of RCB by 6.49% and the numbers by 9.4 x 10(5). The reduction in RCB proportions and numbers by SRP alone (5.03% and 5.1 x 10(5), respectively) was significantly less. In addition, MM + SRP reduced probing depth by 1.38 mm (compared to 1.01 mm by SRP alone), bleeding on probing was reduced by 25.2% (compared to 13.8% by SRP alone), and a clinical attachment level gain of 1.16 mm (compared to 0.80 mm by SRP alone) was achieved. CONCLUSION: These observations support the hypothesis that RCBs are responsible for periodontal disease and that local antimicrobial therapy using MM + SRP effectively reduces numbers of RCBs and their proportions to a greater extent than SRP alone.
Assuntos
Antibacterianos/uso terapêutico , Bactérias/efeitos dos fármacos , Minociclina/uso terapêutico , Periodontite/microbiologia , Administração Tópica , Antibacterianos/administração & dosagem , Bactérias/classificação , Bacteroides/efeitos dos fármacos , Bacteroides/isolamento & purificação , Contagem de Colônia Microbiana , Placa Dentária/microbiologia , Raspagem Dentária , Sistemas de Liberação de Medicamentos , Feminino , Hemorragia Gengival/tratamento farmacológico , Hemorragia Gengival/microbiologia , Humanos , Masculino , Microesferas , Pessoa de Meia-Idade , Minociclina/administração & dosagem , Perda da Inserção Periodontal/tratamento farmacológico , Perda da Inserção Periodontal/microbiologia , Bolsa Periodontal/tratamento farmacológico , Bolsa Periodontal/microbiologia , Periodontite/tratamento farmacológico , Porphyromonas gingivalis/efeitos dos fármacos , Porphyromonas gingivalis/isolamento & purificação , Aplainamento Radicular , Método Simples-Cego , Resultado do Tratamento , Treponema denticola/efeitos dos fármacos , Treponema denticola/isolamento & purificaçãoRESUMO
BACKGROUND: The purpose of this double-masked study was to evaluate effects of intravenous sedation (IVS) using midazolam or diazepam during periodontal procedures on patient recall, psychomotor response, oxygen saturation, and hemodynamic factors. METHODS: Seventeen patients received either two or three scheduled periodontal surgeries under IVS with midazolam, diazepam, or placebo control. Patients were monitored throughout the procedure for hemodynamic variables, percent oxygen saturation, level of recall of common objects presented at baseline, and psychomotor function via the perceptual speed test (PST). RESULTS: Fifteen patients completed the study with average titrated dosages of 3.3 and 12.1 mg for midazolam and diazepam, respectively. Within the limitations of the study, there were few differences observed between the drugs with regard to hemodynamic variables, oxygen saturation, and overall percentage of objects recalled by patients sedated with either drug. However, midazolam was found to cause a greater incidence of amnesia lasting up to 30 minutes when compared to placebo. Patients on diazepam required an average of 15 minutes longer to recover accuracy as measured by the PST. CONCLUSIONS: The results suggest that diazepam and midazolam each may have advantages for IVS. In procedures lasting over 45 minutes, diazepam appears to be more clinically advantageous including a wider margin of safety during titration and gradual recovery. Midazolam may be used for shorter procedures for faster onset of action, predictable amnesic effects, and relatively rapid recovery.
Assuntos
Pressão Sanguínea/efeitos dos fármacos , Sedação Consciente , Diazepam/administração & dosagem , Frequência Cardíaca/efeitos dos fármacos , Hipnóticos e Sedativos/administração & dosagem , Midazolam/administração & dosagem , Oxigênio/sangue , Doenças Periodontais/cirurgia , Adulto , Idoso , Período de Recuperação da Anestesia , Anestesia Dentária , Estudos Cross-Over , Método Duplo-Cego , Feminino , Humanos , Injeções Intravenosas , Masculino , Rememoração Mental/efeitos dos fármacos , Pessoa de Meia-Idade , Placebos , Desempenho Psicomotor/efeitos dos fármacos , Fatores de TempoRESUMO
For many years, dentists have recognized the importance of dental health to general health. Recent research findings point to possible associations between chronic oral infections such as periodontitis and systemic health problems. This article will review the evidence for some of these associations and explore factors that may underlie oral-systemic disease connections.
Assuntos
Doenças Cardiovasculares/etiologia , Trabalho de Parto Prematuro/etiologia , Doenças Periodontais/complicações , Infecções Respiratórias/etiologia , Infecções Bacterianas/complicações , Infecções Bacterianas/microbiologia , Doenças Cardiovasculares/microbiologia , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Doenças Periodontais/microbiologia , Gravidez , Infecções Respiratórias/microbiologiaRESUMO
This article discusses the biologic basis of periodontal disease and diabetes mellitus. Following is a consideration of the possibility of a link between diabetes and periodontal disease. Mounting evidence suggests that there is, indeed, a connection between periodontal disease and diabetes.