Prospective, randomized, controlled, noninferiority clinical trial to evaluate the safety and efficacy of absorbable macroporous polysaccharide composites as adjunct to hemostasis during open surgery.

BACKGROUND: To address intraoperative bleeding in cardiac surgery, reducing blood transfusion requirements, is mandatory to achieve effective hemostasis. Hemostatic agents may limit localized persistent bleeding. The introduction of carboxymethyl-chitosan component into the hemostatic agent and the application of the radiation crosslinking technique maintain its capacity for achieving intraoperative hemostasis, thus increasing the clinical utility. METHODS: A prospective, noninferiority and randomized controlled clinical trial to compare the safety and efficacy of absorbable macroporous polysaccharide composites (AMPC, treatment group) with compound microporous polysaccharide hemostatic powder (CMPHP, control group) (2:1 ratio) as adjuncts to hemostasis in open surgery. The main indication was used for hemostasis in various traumatic hemorrhage areas, including cardiothoracic, vascular, and general surgery. The primary endpoint was success rate of hemostasis within 300 s (at a 10% noninferiority margin). The secondary endpoint was hemostasis time. Both endpoints were assessed in the modified intention-to-treat (MITT) population. Safety parameters were assessed. This study is fully compliant with the CONSORT statement. RESULTS: Randomized patients in AMPC and CMPHP groups were 168 and 84, respectively. In MITT population, the success rates of hemostasis within 300 s were 98.8% (163 of 165) in AMPC and 94.0% (78 of 83) in CMPHP (treatment difference 4.8% [95% CI -0.57% to 10.20%]). AMPC was thus noninferior to CMPHP. Hemostasis time (median [interquartile range]) with AMPC (87 [52.5, 180] s) was better than CMPHP (110 [54.5, 181] s). Changes in laboratory parameters over time and shifts to abnormal values were typical of surgeries and similar between two groups. No noticeable adverse effects associated with AMPC or CMPHP were observed. CONCLUSIONS: AMPC is well tolerated as topical hemostatic agent, noninferior to commercial CMPHP, and exhibits excellent safety. This study provides a novel hemostatic agent which appears to offer significant clinical advantage in various hemorrhage areas.

Magnetic Anisotropy: Structural Correlation of a Series of Chromium(II)-Amidinate Complexes.

Systematic substituent variations on amidinate ligands bring delicate changes of CrN4 coordination in a family of chromium(II) complexes with the common formula of Cr(RNC(CH3)NR)2, where R = iPr (1), Cy (2), Dipp (Dipp = 2, 6-diisopropylphenyl) (3), and tBu (4). With the largest substituent group, 4 shows the largest distortion of the N4 coordination geometry from square-planar to seesaw shape, which leads to its field-induced single-molecule magnet (SMM) behavior. This is an indication that 4 has the strongest axial magnetic anisotropy and/or optimized magnetic relaxation process. Combined with high-frequency/field electron paramagnetic resonance (HF-EPR) experiments and ab initio calculations, we deduce that the smallest energy gap between ground 4Ψ0 and the first excited 4Ψ1 orbitals in 4 contributes the most to its strongest magnetic anisotropy. Moreover, the lower E value of 4 ensures its being a field-induced SMM. Specifically, the D and E values were found to be correlated to the dihedral angle between the ΔN1CrN2 and ΔN3CrN4 triangles, indicating that distortion from ideal square-planar geometry to the seesaw help increase axial magnetic anisotropy and suppress the transversal part. Thus, the study on this system not only expands the family of Cr(II)-based SMMs but also contributes to a deeper understanding of magneto-structural correlation in four-coordinate Cr(II) SMMs.

S, N co-doped graphene quantum dots decorated CdSe for enhanced photoelectric properties.

Cadmium selenide and S, N co-doped graphene quantum dots (CdSe/S, N-GQDs) nanocomposites were synthesized via a solvothermal method. The results show that S, N-GQDs have a grain size of around 5 nm and an average height of 0.5 nm, which contains only 1-2 layers of graphene sheets. The CdSe/S, N-GQDs composites exhibit distinct lattice fringes with a layer spacing of 0.24 and 0.35 nm, corresponding to (1120) and (111) crystal planes of S, N-GQDs and the cubic CdSe, respectively. The photoelectric properties of CdSe/S, N-GQDs were evaluated under ultraviolet light (365 nm) irradiation. Compared with CdSe and CdSe/GQDs, CdSe/S, N-GQDs composites have the largest photocurrent density of 4.286 × 10-5 A cm-2, which is about 10.5 times and 7.5 times as high as that of CdSe and CdSe/GQDs, respectively. The increase in photocurrent density of CdSe/S, N-GQDs can be attributed to the incorporation of S and N to promote separation of photogenerated carriers. Moreover, S, N-GQDs are nano-fragments of graphene, which can provide a larger specific surface area and greatly increase the contact surface with CdSe. In addition, the photoelectric properties of CdSe/S, N-GQDs composites can be adjusted by varying the doping ratio. When the doping ratio is 1:1, CdSe/S, N-GQDs have the best photoelectric performance.

Photochemically Tuned Magnetic Properties in an Erbium(III)-Based Easy-Plane Single-Molecule Magnet.

The magnetic properties of single-molecule magnets can be controlled by external conditions such as light, pressure, and temperature. Among these conditions, photochemical control is the best approach due to the accessibility and rapid conduction of light. In this work, an Er(III)-based complex with photoactive ligand bpe, [Er(nat)3·MeOH·bpe] (1, bpe = 1,2-bis(2-pyridyl)ethylene, nat = 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione), was synthesized. The auxiliary ligand nat and cyclized ligand bpe stacked reasonably in the crystal structure. Two molecules of 1 experienced the [2, 2]-cycloaddition reaction under the UV irradiation in the solid state and [{Er(nat)3MeOH}2(tpcb)] (2, tpcb = tetrakis(4-pyridyl)cyclobutane) was produced. The slight change in the structure around Er(III) ions leads to the different magnetic properties, which illustrates the photochemical control of the magnetic properties of single-molecule magnets.

Tracking the Process of a Solvothermal Domino Reaction Leading to a Stable Triheteroarylmethyl Radical: A Combined Crystallographic and Mass-Spectrometric Study.

A new free carbon radical was obtained in a microwave-assisted solvothermal reaction of the primary amine (1-methyl-1H-benzo[d]imidazol-2-yl)methanamine with FeCl3 ⋅6 H2 O in methanol at 140 °C. Through a combination of crystallography and electrospray ionization mass spectrometry, the reaction process was studied. The longest domino reaction includes 14 steps and forms up to 12 new covalent bonds (9 C-N and 3 C-C bonds) and 3 five-membered heterocycles. For the first time, the homolytic cleavage of a C-O bond was used to synthesize a triarylmethyl radical.

Series of Single-Ion and 1D Chain Complexes Based on Quinolinic Derivative: Synthesis, Crystal Structures, HF-EPR, and Magnetic Properties.

By utilizing the quinolinic derivative, 8-carboxymethoxy-2-carboxylicquinoline (L), five transition metal coordination complexes, [M(L)(H2O)3]·H2O] (M = Mn (1), Co (2)), [Ni(L)(H2O)2] (3), and {[M(L)](H2O)} n (M = Ni (4), Cu (5)), were synthesized by hydrothermal methods employing similar synthetic strategies. The crystal structures, magnetism and high-field EPR were characterized for the obtained compounds. 1-3 are mononuclear compounds. 1 and 2 have pentagonal bipyramidal geometry, while 4 and 5 exhibit one-dimensional zig-zag chain. Direct current magnetic and EPR studies demonstrate that compound 2 has large and positive D value (∼70.4 cm-1), indicating the easy plane magnetic anisotropies of 2. This D value is the largest one in the reported Co(II) complexes with pentagonal bipyramidal geometry. Field-induced slow magnetic relaxation behavior was observed for 2 by the dynamic ac magnetic susceptibility measurements. The dc magnetic susceptibility studies of 4 and 5 give similar weak MII-MII antiferromagnetic interactions ( J = -1.50 and -3.55 K for 4 and 5, respectively). High-field EPR results show that 4 can be considered as a quantum antiferromagnet.

Series of Highly Stable Lanthanide-Organic Frameworks Constructed by a Bifunctional Linker: Synthesis, Crystal Structures, and Magnetic and Luminescence Properties.

By utilizing a preselected functional ligand produced by 1 H-imidazole-4,5-dicarboxylic acid, three isostructural lanthanide coordination polymers (CPs), denoted as {[Ln2(OH)2(L)2]·(DMF)·(H2O)4} n (Ln = Gd (1), Eu (2), Dy (3); L = 1-(4-carboxybenzyl)imidazole-4-carboxylic acid), containing a 1D infinite [Ln4(OH)4] subchain have been successfully constructed. The highly connected mode between the multifunctional ligand and 1D building units is responsible for the exceptional chemical stability of three lanthanide CPs. In addition, a study of the magnetic properties reveals that 1 displays a large magnetic entropy change (-Δ Sm = 30.33 J kg-1 K-1 with T = 2 K and Δ H = 7 T). Furthermore, genetic algorithm and quantum Monte Carlo methods were combined to simulate the magnetic coupling parameters of compound 1, shedding light on the effect of linking bridges on magnetic propagation. 2 shows intense luminescence in the range of 350-710 nm. Comparably, magnetic studies of 3 reveal the existence of a metamagnetic transformation from an antiferromagnetic interaction to a ferromagnetic interaction along with a decrease in temperature. Through fitting of the results of HF-EPR measurements, a component of the g tensor is obtained, g|| = 16.4(5), indicating the large anisotropy of 3.

Two-Coordinate Co(II) Imido Complexes as Outstanding Single-Molecule Magnets.

The pursuit of single-molecule magnets (SMMs) with better performance urges new molecular design that can endow SMMs larger magnetic anisotropy. Here we report that two-coordinate cobalt imido complexes featuring highly covalent Co═N cores exhibit slow relaxation of magnetization under zero direct-current field with a high effective relaxation barrier up to 413 cm-1, a new record for transition metal based SMMs. Two theoretical models were carried out to investigate the anisotropy of these complexes: single-ion model and Co-N coupling model. The former indicates that the pseudo linear ligand field helps to preserve the first-order orbital momentum, while the latter suggests that the strong ferromagnetic interaction between Co and N makes the [CoN]+ fragment a pseudo single paramagnetic ion, and that the excellent performance of these cobalt imido SMMs is attributed to the inherent large magnetic anisotropy of the [CoN]+ core with |MJ = ± 7/2⟩ ground Kramers doublet.

Evaluation of Tc-99m-3PRGD2 Integrin Receptor Imaging in the Differential Diagnosis of Breast Lesions and Comparison With Mammography.

PURPOSE: The aims of this study were to evaluate and compare efficacies of Tc-99m-3PRGD2 integrin receptor imaging under variety of conditions for the diagnosis of breast lesions, in addition to comparison with mammography. MATERIALS AND METHODS: Seventy-two female patients with established breast lesions were recruited. All patients were examined by Tc-99m-3PRGD2 integrin receptor imaging and mammography. Whole-body scan and SPECT/CT were acquired at dual time points of 2 and 4 h after injection using standard protocol. The processed images were evaluated by visual and semi-quantitative analysis. Mammography was performed using up and down and internal and external oblique views. The gold standard of diagnosis was based on histopathological findings. RESULTS: Sensitivity greater than 85.0% and accuracy greater than 80.0% were observed under any technical method. For dense mammary gland, the sensitivity, specificity, and accuracy of Tc-99m-3PRGD2 SPECT/CT 4-h imaging and mammography were 95.2, 75.0, and 90.7%, and 71.4, 58.3, and 68.5% respectively. Combined two methods' sensitivity, specificity, and accuracy for detection of breast cancer can reach 98.3, 86.7, and 96.0%. CONCLUSIONS: Tc-99m-3PRGD2-based molecular imaging is a sensitive method for the differential diagnosis of breast lesions. Particularly, Tc-99m-3PRGD2-SPECT/CT has better diagnostic value in dense mammary gland as compared with mammography. Combining two methods can significantly improve the diagnostic efficiency.

Field-Induced Slow Magnetic Relaxation in an Octacoordinated Fe(II) Complex with Pseudo-D2d Symmetry: Magnetic, HF-EPR, and Theoretical Investigations.

An octacoordinated Fe(II) complex, [FeII(dpphen)2](BF4)2·1.3H2O (1; dpphen = 2,9-bis(pyrazol-1-yl)-1,10-phenanthroline), with a pseudo-D2d-symmetric metal center has been synthesized. Magnetic, high-frequency/-field electron paramagnetic resonance (HF-EPR), and theoretical investigations reveal that 1 is characterized by uniaxial magnetic anisotropy with a negative axial zero-field splitting (ZFS) (D ≈ -6.0 cm-1) and a very small rhombic ZFS (E ≈ 0.04 cm-1). Under applied dc magnetic fields, complex 1 exhibits slow magnetic relaxation at low temperature. Fitting the relaxation time with the Arrhenius mode combining Orbach and tunneling terms affords a good fit to all the data and yields an effective energy barrier (17.0 cm-1) close to the energy gap between the ground state and the first excited state. The origin of the strong uniaxial magnetic anisotropy for 1 has been clearly understood from theoretical calculations. Our study suggests that high-coordinated compounds featuring a D2d-symmetric metal center are promising candidates for mononuclear single-molecule magnets.

Insights into Magnetic Interactions in a Monodisperse Gd12 Fe14 Metal Cluster.

The largest Ln-Fe metal cluster [Gd12 Fe14 (µ3 -OH)12 (µ4 -OH)6 (µ4 -O)12 (TEOA)6 (CH3 COO)16 (H2 O)8 ]⋅(CH3 COO)2 (CH3 CN)2 ⋅(H2 O)20 (1) and the core-shell monodisperse metal cluster of 1 a@SiO2 (1 a=[Gd12 Fe14 (µ3 -OH)12 (µ4 -OH)6 (µ4 -O)12 (TEOA)6 (CH3 COO)16 (H2 O)8 ]2+ ) were prepared. Experimental and theoretical studies on the magnetic properties of 1 and 1 a@SiO2 reveal that encapsulation of one cluster into one silica nanosphere not only effectively decreases intermolecular magnetic interactions but also significantly increases the zero-field splitting effect of the outer layer Fe3+ ions.

Large Easy-Plane Magnetic Anisotropy in a Three-Coordinate Cobalt(II) Complex [Li(THF)4 ][Co(NPh2 )3 ].

Magnetic anisotropy is the key element in the construction of single-ion magnets, a kind of nanomagnets for high-density information storage. This works describes an unusual large easy-plane magnetic anisotropy (with a zero-field splitting parameter D of +40.2 cm-1 ), mainly arising from the second-order spin-orbit coupling effect in a trigonal-planar CoII complex [Li(THF)4 ][Co(NPh2 )3 ], revealed by combined studies of magnetism, high frequency/field electron paramagnetic resonance spectroscopy, and ab initio calculations. Meanwhile, the field-induced slow magnetic relaxation in this complex was mainly attributed to the Raman process.

Supramolecular Interactions Direct the Formation of Two Structural Polymorphs from One Building Unit in a One-Pot Synthesis.

Two polymorphs of supramolecular isomers, a discrete dimer and a zig-zag chain, having the same chemical composition, [Mn(Hbit)Cl2 ] (Hbit=1-methyl-2-(1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazole), were obtained solvothermally in a one-pot synthesis. The isomers differ in a number of ways: orange blocks versus pale-yellow needles, triclinic P1‾ versus orthorhombic Pbcn, double µ2 -Cl versus alternate single and triple µ2 -Cl, coordination number 5 versus 6, and antiparallel versus parallel near-neighbor orientation of Hbit. The packing in each case is driven by the supramolecular interactions, H-bonds (N-H⋅⋅⋅Cl, C-H⋅⋅⋅Cl) and π⋅⋅⋅π overlaps, calculated to be in the range 20-36 kcal mol-1 . Calculations gave a difference of only 2 kcal mol-1 in favor of the dimer, which confirms with the observation of principally the dimer at short reaction time. ESI-MS spectra of the dissolved crystals reveal the same fragments with similar distributions. The presence of two fragments at m/z 286.96 [MnIV (Hbit)Cl-2H]+ and 323.94 [MnIII (Hbit)Cl2 ]+ indicates that [Mn(Hbit)Cl2 ] is the building unit in both cases; thus, the different orientations of the ligands lead to the two polymorphs stabilized by the respective supramolecular interactions. Importantly, the chain form represents the first example with alternate single and triple µ2 -Cl bridges. The magnetic interactions are weakly antiferromagnetic in both cases, with J in the range 0.07-0.34 cm-1 ; however, high-field EPR analysis reveals moderate magneto-anisotropy with D=0.26(1) cm-1 , E=0.06(1) cm-1 and D=0.17(1) cm-1 , E=0.03(1) cm-1 , respectively.

Slow Magnetic Relaxations in Cobalt(II) Tetranitrate Complexes. Studies of Magnetic Anisotropy by Inelastic Neutron Scattering and High-Frequency and High-Field EPR Spectroscopy.

Three mononuclear cobalt(II) tetranitrate complexes (A)2[Co(NO3)4] with different countercations, Ph4P+ (1), MePh3P+ (2), and Ph4As+ (3), have been synthesized and studied by X-ray single-crystal diffraction, magnetic measurements, inelastic neutron scattering (INS), high-frequency and high-field EPR (HF-EPR) spectroscopy, and theoretical calculations. The X-ray diffraction studies reveal that the structure of the tetranitrate cobalt anion varies with the countercation. 1 and 2 exhibit highly irregular seven-coordinate geometries, while the central Co(II) ion of 3 is in a distorted-dodecahedral configuration. The sole magnetic transition observed in the INS spectroscopy of 1-3 corresponds to the zero-field splitting (2(D2 + 3E2)1/2) from 22.5(2) cm-1 in 1 to 26.6(3) cm-1 in 2 and 11.1(5) cm-1 in 3. The positive sign of the D value, and hence the easy-plane magnetic anisotropy, was demonstrated for 1 by INS studies under magnetic fields and HF-EPR spectroscopy. The combined analyses of INS and HF-EPR data yield the D values as +10.90(3), +12.74(3), and +4.50(3) cm-1 for 1-3, respectively. Frequency- and temperature-dependent alternating-current magnetic susceptibility measurements reveal the slow magnetization relaxation in 1 and 2 at an applied dc field of 600 Oe, which is a characteristic of field-induced single-molecule magnets (SMMs). The electronic structures and the origin of magnetic anisotropy of 1-3 were revealed by calculations at the CASPT2/NEVPT2 level.

Bone age recognition based on mask R-CNN using xception regression model.

Background and Objective: Bone age detection plays an important role in medical care, sports, judicial expertise and other fields. Traditional bone age identification and detection is according to manual interpretation of X-ray images of hand bone by doctors. This method is subjective and requires experience, and has certain errors. Computer-aided detection can effectually enhance the validity of medical diagnosis, especially with the fast development of machine learning and neural network, the method of bone age recognition using machine learning has gradually become the focus of research, which has the advantages of simple data pretreatment, good robustness and high recognition accuracy. Methods: In this paper, the hand bone segmentation network based on Mask R-CNN was proposed to segment the hand bone area, and the segmented hand bone region was directly input into the regression network for bone age evaluation. The regression network is using an enhancd network Xception of InceptionV3. After the output of Xception, the convolutional block attention module is connected to refine the feature mapping from channel and space to obtain more effective features. Results: According to the experimental results, the hand bone segmentation network model based on Mask R-CNN can segment the hand bone region and eliminate the interference of redundant background information. The average Dice coefficient on the verification set is 0.976. The mean absolute error of predicting bone age on our data set was only 4.97 months, which exceeded the accuracy of most other bone age assessment methods. Conclusion: Experiments show that the accuracy of bone age assessment can be enhancd by using the Mask R-CNN-based hand bone segmentation network and the Xception bone age regression network to form a model, which can be well applied to actual clinical bone age assessment.

Clinical Features and Prognosis of Uncommon Metastatic Breast Cancer: A Retrospective Analysis of 82 Cases.

With the improvement of diagnostic techniques, numerous uncommon metastases derived from breast cancer were reported. However, very few studies explored the clinical characteristics and prognostic patterns of these patients. A total of 82 cases of uncommon metastatic breast cancer (MBC) registered at our hospital from January 1, 2010, to July 1, 2022, were selected for this retrospective study. The diagnoses of uncommon metastases were based on pathology, and the potential prognostic indicators (overall survival [OS], uncommon disease-free interval [uDFI], and remaining survival [RS]) were estimated. The uncommon metastases involved distant soft tissue, parotid gland, thyroid, digestive system, urinary system, reproductive system, bone marrow, and pericardium. Stepwise multivariate Cox regression analysis indicates age ≤ 35 is an independent risk factor of poor outcome of OS, uDFI, and RS in uncommon MBC patients. Meanwhile, uncommon metastasis combined with common visceral metastasis is an independent risk factor for poor RS of uncommon MBC patients, with a hazard ratio of 6.625 (95% confidence interval = 1.490-29.455, P = .013). Post hoc pairwise comparisons showed that uncommon MBC patients who developed bone-only metastasis survived longer than those concomitant with common visceral metastasis (P = .029). Although the incidence is low, uncommon MBC may involve multiple metastatic sites. The delayed diagnosis of uncommon metastases could lead to systemic progression of the disease. However, patients who only develop uncommon metastasis have a significantly better prognosis than that of those combined with common visceral metastasis. Even for those complicated by bone-only metastasis, active treatment of bone metastases can still achieve substantially longer survival.

Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo.

Breast cancer is one of the most common malignant tumors in women and it is the most frequently diagnosed cancer in the world. Ampelopsin (AMP) is a purified component from the root of Ampelopsis grossedentata. It is reported that AMP could significantly inhibit the proliferation of breast cancer cells. However, the antitumor mechanism against breast cancer has not yet been fully elucidated. The purpose of this work was to study the role of AMP against breast cancer MDA-MB-231 cells and to further investigate the underlying mechanism. PI3K/AKT/mTOR plays a very important role in tumor cell growth and proliferation and we hypothesize that AMP may inhibit this pathway. In the present work, the results showed that AMP could significantly inhibit the growth of breast cancer MDA-MB-231 cells in vitro and in vivo. In addition, treatment with AMP decreased the levels of PI3K, AKT and mTOR, as well as cyclin B1 expression, followed by p53/p21 pathway activation to arrest the cell cycle at G2/M. Moreover, it demonstrated a positive association between cyclin B1 and PI3K/AKT/mTOR levels. Importantly, this pathway was found to be regulated by cyclin B1 in MDA-MB-231 cells treated with AMP. Also, it was observed that cyclin B1 overexpression attenuated cell apoptosis and weakened the inhibitory effects of AMP on cell proliferation. Together, AMP could inhibit breast cancer MDA-MB-231 cell proliferation in vitro and in vivo, due to cell cycle arrest at G2/M by inactivating PI3K/AKT/mTOR pathway regulated by cyclin B1.

TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor outcome and lacks of approved targeted therapy. Overexpression of epidermal growth factor receptor (EGFR) is found in more than 50% TNBC and is suggested as a driving force in progression of TNBC; however, targeting EGFR using antibodies to prevent its dimerization and activation shows no significant benefits for TNBC patients. Here we report that EGFR monomer may activate signal transducer activator of transcription-3 (STAT3) in the absence of transmembrane protein TMEM25, whose expression is frequently decreased in human TNBC. Deficiency of TMEM25 allows EGFR monomer to phosphorylate STAT3 independent of ligand binding, and thus enhances basal STAT3 activation to promote TNBC progression in female mice. Moreover, supplying TMEM25 by adeno-associated virus strongly suppresses STAT3 activation and TNBC progression. Hence, our study reveals a role of monomeric-EGFR/STAT3 signaling pathway in TNBC progression and points out a potential targeted therapy for TNBC.

Early Application of Palbociclib Plus Endocrine Therapy in HR+/HER2- Metastatic Breast Cancer: A Better Choice Based on Data From the Chinese Population.

Background: Palbociclib is the most widely used cyclin-dependent kinase 4/6 inhibitor in China, but its early application efficacy on Chinese metastatic breast cancer (MBC) patients was reported deficiently. Methods: Between February 2019 to December 2021, 95 female hormone receptor-positive (HR+)/human epidermal growth factor receptor-2 negative (HER2-) patients with MBC received palbociclib combined with AI or fulvestrant were retrospectively analyzed in our center. The primary outcome was progression-free survival (PFS). The objective response rate and clinical benefit rate (CBR) were evaluated. Results: The median follow-up period was 15 months (range from 2 to 37). Palbociclib performed superiorly when applicated in first-and-second line therapy than in later lines (P = .002). Palbociclib combined with AI or fulvestrant had a median PFS of 34 months (95% confidence interval [CI] = 6.87-61.13) and 12 months (95%CI = 7.76-16.24), respectively. Univariate subgroup analysis showed that the previous history of salvage chemotherapy (P = .015) and the presence of liver metastases (P < .001) significantly affected the efficacy of palbociclib. Despite the existence of liver metastases and primary endocrine resistance, which are two independent predictors of poor prognosis, early application of palbociclib in advanced stage can bring further benefits to these two groups of patients, rather than choosing salvage chemotherapy in the first place. Conclusion: Palbociclib combined with endocrine therapy has a favorable efficacy and acceptable toxicity in HR+/HER2- Chinese MBC patients. Better performance can be seen when palbociclib was applicated in the early stage.

Magnetic anisotropy of two tetrahedral Co(II)-halide complexes with triphenylphosphine ligands.

Recently, the choice of ligand and geometric control of mononuclear complexes, which can affect the relaxation pathways and blocking temperature, have received wide attention in the field of single-ion magnets (SIMs). To find out the influence of the coordination environment on SIMs, two four-coordinate mononuclear Co(II) complexes [NEt4][Co(PPh3)X3] (X = Cl-, 1; Br-, 2) have been synthesized and studied by X-ray single crystallography, magnetic measurements, high-frequency and -field EPR (HF-EPR) spectroscopy and theoretical calculations. Both complexes are in a cubic space group Pa3̄ (No. 205), containing a slightly distorted tetrahedral moiety with crystallographically imposed C3v symmetry through the [Co(PPh3)X3]- anion. The direct-current (dc) magnetic data and HF-EPR spectroscopy indicated the anisotropic S = 3/2 spin ground states of the Co(II) ions with the easy-plane anisotropy for 1 and 2. Ab initio calculations were performed to confirm the positive magnetic anisotropies of 1 and 2. Frequency- and temperature-dependent alternating-current (ac) magnetic susceptibility measurements revealed slow magnetic relaxation for 1 and 2 at an applied dc field. Finally, the magnetic properties of 1 and 2 were compared to those of other Co(II) complexes with a [CoAB3] moiety.