What Is the Rate of Antimicrobial Resistance of a Prosthetic Joint Infection in a Major Orthopaedic Centre?

Periprosthetic joint infections (PJIs) are important factors in decreasing the success of hip and knee arthroplasties. It is a necessity to explore the epidemiological data and develop applications for rational antibiotic use, to address future infection control concerns. We aimed to investigate the microorganisms that were responsible and the related antibiograms in 121 patients with PJI, who were managed by two-stage revision surgery. Patients' data records, demographics, comorbidities, sites of arthroplasty, synovial fluid and deep tissue culture results and antibiotic treatment were summarized on a standardized case report form. There were 43 (35.5%) culture-negative PJI cases and 12 (9.9%) polymicrobial growths. The causative pathogens included Gram-positive (50.4%) and Gram-negative microorganisms (23.1%) and fungi (0.8%). Methicillin resistance was 64.3% for S. aureus and 89.5% for coagulase-negative staphylococcus (CoNS). The extended spectrum beta lactamase (ESBL) rate for Enterobacteriaceae was 68.4%. This study shows that antibiotic resistance is encountered in more than half of the cases, which is valid for all microorganisms most common in PJI. The success of treatment decreases significantly in cases where antibiotic-resistant microorganisms are isolated or in cases where the culture is negative.

Systematic triage and treatment of earthquake victims: Our experience in a tertiary hospital after the 2023 Kahramanmaras earthquake.

OBJECTIVES: The aim of this study was to evaluate the benefits of our triage system in acceleration of intervention for the musculoskeletal injuries and clinical follow-ups of trauma patients admitted to our center after the Kahramanmaras earthquake. PATIENTS AND METHODS: Between February 6th, 2023 and February 20th, 2023, a total of 439 patients (207 males, 232 females; mean age: 37.1±19.1 years; range, 1 to 94 years) with earthquake-related musculoskeletal injuries after the Kahramanmaras earthquake were retrospectively analyzed. Data including age, sex, referral city information, removal time from the rubbles, physical examination findings, clinical photos, fasciotomy and amputation stumps and levels, and X-ray images and computed tomography images of all patients were shared and archived in the WhatsApp (Meta Platforms, Inc.® ATTN/CA, USA) group called 'Earthquake' created by orthopedic surgeons. To complete the patient interventions as soon as possible and to ensure order, the patients were distributed with the teams in order through this group by the consultant orthopedic surgeon. The treatments were applied and recorded according to the skin and soft tissue conditions, and fractures of the patients. All treatments were carried out with a multi-disciplinary approach. RESULTS: Of the patients, 16.2% were children. Lower limb injuries constituted 59.07% of musculoskeletal injuries. Upper limb, pelvic, and spinal cord injuries were observed in 21.9%, 12.7%, and 6.25%, respectively. Conservative treatment was applied to 183 (41.68%) patients. The most common surgical intervention was debridement (n=136, 53.1%). External fixation was applied in the first stage to 21 (8.2%) patients with open fractures. The mean removal time from the rubbles was 32.1±29.38 h. A total of 118 limb fasciotomy operations were applied to the patients. Fifty limb amputations were performed in 40 patients at the last follow-up due to vascular insufficiency and infection. CONCLUSION: Based on our study results, we believe that a triage system using a good communication and organization strategy is beneficial to prevent treatment delay and possible adverse events in future disasters.

Role of Biomarkers in Periprosthetic Joint Infections.

Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1-3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies.

Comparison of tension band wiring and plate fixation in Mayo type 2A olecranon fractures.

OBJECTIVES: This study aims to compare clinically and functionally patients who had previously undergone tension band wiring (TBW) or plate fixation (PF) procedure due to the diagnosis of Mayo type 2A olecranon fracture in our clinic. PATIENTS AND METHODS: Data of 92 patients (51 males, 41 females; mean age 42.3±12.6 years; range, 16 to 75 years) operated on for olecranon fractures between January 2014 and December 2018 were recorded retrospectively. Forty-four patients received TBW and 48 patients received PF treatment. Their Disabilities of the Arm, Shoulder, and Hand (DASH) and Mayo scores and elbow range of motion (ROM) measurements were used for clinical and functional evaluations. Data including the time to return to work, revision rate, and follow-up time were also recorded. RESULTS: The mean follow-up time was 38.2±17.2 months. Patients returned to work in 9.2±4.1 weeks in the TBW group and 7.8±3.6 weeks in the PF group (p=0.279). The revision rate was 14% in the TBW group and 2% in the PF group (p=0.335). The mean DASH score was 10.0±1.8 in the TBW group and 7.7±1.2 in the PF group (p=0.001). The mean Mayo score was 84.0±9.3 in the TBW group and 88.3±9.1 in the PF group (p=0.049). For elbow flexion-extension ROM, 4° of difference was measured in favor of the PF group (p=0.043). Mean Mayo score, mean DASH score, and mean flexion-extension ROM values were statistically significantly different between the two groups. CONCLUSION: Both surgical techniques are suitable and reliable in the treatment of olecranon fractures. Although TBW treatment is low-cost and simple to apply, its biggest disadvantage is a high rate of secondary surgery for implant removal due to irritation of the skin.

Comparative Analysis of Single Lateral Locked Plate and Double Locked Plate Application in the Treatment of Bicondylar Tibial Plateau Fractures.

Background and objective Bicondylar tibial plateau fractures (BTPFs) have been controversial in terms of surgery planning, due to articular joint surface comminution, severe soft tissue injury, and the risk of complications. The aim of this study was to conduct a clinical, functional, and radiologic comparison of the dual locked plate (DLP) and single lateral locked plate (SLLP) techniques. Methods Retrospectively analysed were 54 patients who underwent surgical treatment with DLP or SLLP due to the diagnosis of BTPFs, between January 2018 and June 2020. Patients were evaluated in the clinic with regard to their demographic characteristics, mechanisms of injury, follow-up periods, measurement of the range of motion degrees, functional scores, and radiographic parameters. The Knee Injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score (Lysholm) and Oxford Knee Score (OKS) were chosen as the functional scores. The condylar width, medial proximal tibial angle (MPTA), posterior tibial slope (PTS) and fracture union time were calculated radiographically. Results The patients in the DLP group achieved significantly higher scores for all three scales when the KOOS, Lysholm, and OKS, respectively (P = 0.008, P = 0.048, P = 0.006), were compared. Radiographically, the mean increase in the condylar width of 1.72 mm in the DLP group and 2.59 mm in the SLLP group was measured (P = 0.010, P = 0.010, respectively). The mean decrease in MPTA was 1.75° in the DLP group and 3.54° in the SLLP group, which was statistically significant (P = 0.005, P = 0.001, respectively). An increase in the posterior tibial slope was measured at a mean of 1.8° in the DLP group and 1.4° in the SLLP group (P = 0.001, P = 0.008, respectively). On the other hand, when the condylar width, MPTA and PTS between the DLP and SLLP groups were compared, no significant difference was found (P = 0.179, P = 0.247, P = 0.611, respectively). Conclusion Better results were obtained in patients who underwent the DLP procedure when compared to those who had the SLLP. There was no radiographic difference between the two surgical procedures. Although DLP is an effective and reliable method in the treatment of BTPFs, the SLLP procedure also provides satisfactory results in patients with appropriate indications.