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1.
J Oral Maxillofac Surg ; 76(9): 2027-2032, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29715449

RESUMO

PURPOSE: The type and extent of surgery for benign parotid tumors are a subject of debate. We aimed to measure and compare hospital stay, operative time, and complication rates associated with superficial parotidectomy (SP) and partial superficial parotidectomy (PSP). MATERIALS AND METHODS: This retrospective cohort study included all patients who underwent surgery for benign parotid gland tumors in our tertiary center between January 2006 and March 2014 and were followed up for at least 3 years. The predictor variable was the type of parotidectomy, and the main outcome parameters were operative time, hospital stay, and postoperative complications. The demographic characteristics (age and gender), clinical history, and preoperative findings were obtained from patient records. The Kolmogorov-Smirnov test, Mann-Whitney U test, and χ2 test were used to analyze the data. P < .05 was considered statistically significant. RESULTS: The sample was composed of 321 patients (184 men and 137 women) with a mean age of 54.0 ± 14.7 years (range, 18 to 87 years). Of these, 190 underwent SP and 131 underwent PSP. Pleomorphic adenoma was the most common tumor (83 patients, 53%), followed by Warthin tumor (50 patients, 32%). The mean hospital stay was 6.7 ± 2.3 days in the SP group and 4.8 ± 2.4 days in the PSP group (P < .001). The mean operative times in the SP and PSP groups were 134.0 ± 24.6 and 92.1 ± 21.9 minutes, respectively (P < .001). The overall complication rates were 21.6% and 12.2% in the SP and PSP groups, respectively (P = .031). No tumor recurrence was observed in either group. CONCLUSIONS: Compared with the SP group, the PSP group had shorter operative and hospital stay durations and fewer postoperative complications with a comparable recurrence rate. Therefore, PSP should be considered in suitable cases.


Assuntos
Tempo de Internação/estatística & dados numéricos , Duração da Cirurgia , Procedimentos Cirúrgicos Bucais/métodos , Neoplasias Parotídeas/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Parotídeas/patologia , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento
2.
Ann Otol Rhinol Laryngol ; 124(5): 378-83, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25416240

RESUMO

OBJECTIVE: This study evaluated the diagnostic value of magnetic resonance imaging (MRI) and computed tomography (CT) in prevertebral space invasion in patients with head and neck squamous cell carcinomas (HNSCC). SUBJECTS AND METHODS: This study retrospectively reviewed 197 patients with advanced primary laryngeal or hypopharyngeal carcinoma who underwent laryngectomy and neck dissection at our institution. The MRI and CT findings were compared with the surgical findings and postoperative pathology. RESULTS: In 191 patients, the macro- and microscopic margins of the surgical specimens were tumor-free. In the remaining 6 patients, prevertebral space involvement was observed intraoperatively. MRI predicted the absence of prevertebral fascia invasion in 40 of 42 patients with a negative predictive value of 100% and specificity of 95.2%, while the negative predictive value and specificity of CT were 99.2% and 88.2%, respectively. CONCLUSION: Preservation of the retropharyngeal fat plane on MRI reliably predicts the absence of prevertebral space fixation in patients with advanced HNSCC.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias Hipofaríngeas/patologia , Neoplasias Laríngeas/patologia , Imageamento por Ressonância Magnética/métodos , Tomografia Computadorizada por Raios X/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/diagnóstico por imagem , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Humanos , Neoplasias Hipofaríngeas/diagnóstico por imagem , Neoplasias Laríngeas/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço
3.
J Craniofac Surg ; 26(1): e36-7, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25565238

RESUMO

A 44-year-old man developed a slow-growing painless left superolateral orbital mass that extended into the frontal sinus with a complaint of ptosis. Magnetic resonance imaging revealed a heterogenous hyperintense lesion confined to the left frontal bone and superior orbit. The osteoplastic frontal sinus approach was performed to drain supraorbital cholesterol granuloma cyst and for curetting the capsule. Orbitofrontal cholesterol granuloma characteristically arises in the diploe of the superolateral frontal bone. The traditional approach for a primarily orbitofrontal cholesterol granuloma is the transorbital approach including anterior orbitotomy or lateral orbitotomy. However, the osteoplastic approach should be kept in mind as an alternative aprroach for the management of supraorbital lesions in patients with well-pneumatized frontal sinus.


Assuntos
Seio Frontal/cirurgia , Granuloma/cirurgia , Órbita/cirurgia , Doenças Orbitárias/cirurgia , Retalhos Cirúrgicos , Adulto , Blefaroptose/etiologia , Blefaroptose/cirurgia , Colesterol , Granuloma/complicações , Granuloma/diagnóstico , Humanos , Masculino , Doenças Orbitárias/complicações , Doenças Orbitárias/diagnóstico , Procedimentos de Cirurgia Plástica
4.
J Craniofac Surg ; 26(6): 1933-5, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26267561

RESUMO

The aim of our study was to present our retrospective experience in the single-stage surgical reconstruction of 21 tracheal stenosis (TS) patients during the last 17 years, considering the characteristics of the treated stenosis, surgical procedures performed, and postoperative outcomes and complications. All demographic and clinical data were collected retrospectively. Chest and neck computed tomography (CT) scans were performed to assess the stenosis, including length, location, and glottic involvement. The stenotic area was evaluated endoscopically according to an adapted Myer and Cotton grading scale. The aetiology of the (TS) was intubation related in 18 patients and idiopathic in three patients. The duration of intubation was 13.00 ±â€Š6.83 days (range, 1 hour to 27 days). According to the Myers-Cotton classification, mean stage of stenosis for the study group was 3.33 ±â€Š0.66 (range, 2-4). Mean length of the stenosis was 2.05 ±â€Š0.80 (range, 1-3.5) cm. The mean number of stenotic segment involved was 3.67 ±â€Š1.24 (range, 2-6). Mean follow-up for the study group, excluding two patients who died in the postoperative period, was 57 (range, 12-326) months. Of the 19 patients who survived, postoperative decannulation was achieved in 16 patients (76.19%), and decannulation was not achieved in 3 patients (14.29%) who are still on a T-tube. Of the 16 patients who are decannulated successfully, additional procedures were applied in 9 patients. Segmental resection with primary anastomosis is an effective method and can be used as the first option in selected patients of (TS).


Assuntos
Anastomose Cirúrgica/métodos , Procedimentos de Cirurgia Plástica/métodos , Estenose Traqueal/cirurgia , Adolescente , Adulto , Extubação , Causas de Morte , Criança , Endoscopia/métodos , Feminino , Seguimentos , Humanos , Intubação Intratraqueal/efeitos adversos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Retrospectivos , Taxa de Sobrevida , Fatores de Tempo , Tomografia Computadorizada por Raios X/métodos , Estenose Traqueal/classificação , Resultado do Tratamento , Adulto Jovem
5.
J Craniofac Surg ; 25(6): 1998-2001, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25377986

RESUMO

AIM: The aims of this study were to compare radiofrequency tissue reduction (RFTR) and electrocautery (EC) techniques by assessing preoperatively and 8 weeks postoperatively the visual analog scale (VAS), inspiratory peak flowmetry (IPF), and magnetic resonance imaging (MRI) volume measurement of the inferior turbinate and to see whether EC still stands as a valid treatment of inferior turbinate hypertrophy. METHODS: A total of 36 patients were included in the study. An equal number of patients were chosen randomly from 2 groups. Inferior turbinate volumes measured by MRI, IPF, the VAS, and the Sinonasal Outcome Test-20 were used to determine the efficacy of treatment and to compare the 2 groups. RESULTS: Postoperative IPF increase, VAS score decrease, and Sinonasal Outcome Test-20 score decrease were statistically more significant in the EC group, compared with the RFTR group. Although statistically not significant, postoperative inferior turbinate MRI volume decrease was more evident in the EC group when compared with the RFTR group. CONCLUSIONS: Both RFTR and EC techniques could be used as an effective treatment of choice for inferior turbinate hypertrophy, and EC technique is superior to RFTR technique to achieve high efficiency.


Assuntos
Ablação por Cateter/métodos , Eletrocoagulação/métodos , Obstrução Nasal/cirurgia , Conchas Nasais/cirurgia , Adulto , Feminino , Humanos , Hipertrofia/cirurgia , Capacidade Inspiratória/fisiologia , Imageamento por Ressonância Magnética , Masculino , Obstrução Nasal/etiologia , Obstrução Nasal/fisiopatologia , Medição da Dor , Estudos Prospectivos , Resultado do Tratamento , Conchas Nasais/patologia
6.
J Craniofac Surg ; 25(4): 1515-8, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24905944

RESUMO

The aim of our study was to determine the effectiveness of intratympanic α-lipoic acid injection as an otoprotective agent against cisplatin-induced ototoxicity in guinea pigs. Twenty-four adult male albino guinea pigs with normal hearing were divided into 4 groups. The guinea pigs received intraperitoneal cisplatin in group 1, intraperitoneal cisplatin and intratympanic α-lipoic acid in group 2, intratympanic α-lipoic acid in group 3, as well as intraperitoneal cisplatin and intratympanic saline in group 4. Distortion-product otoacoustic emission measurements were obtained for both ears at the following time points: before administration (baseline recording) and on day 3 (72 h later). In group 1 (cisplatin), significant deterioration was observed at all frequencies on day 3 (P < 0.05). In group 2 (cisplatin + α-lipoic acid), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P > 0.05). In group 3 (α-lipoic acid), no significant difference was observed between baseline and day 3 (P > 0.05). In group 4 (cisplatin + saline), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P > 0.05). Cisplatin-induced hearing loss in the guinea pigs may be limited to some extent by the concomitant use of α-lipoic acid. Dose-dependent changes in the possible effects of α-lipoic acid need further investigation. Future morphologic studies may contribute to expose clearly the protective effect of α-lipoic acid.


Assuntos
Antineoplásicos/toxicidade , Antioxidantes/uso terapêutico , Cisplatino/toxicidade , Cóclea/efeitos dos fármacos , Substâncias Protetoras/uso terapêutico , Ácido Tióctico/uso terapêutico , Vestíbulo do Labirinto/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Orelha Média , Cobaias , Perda Auditiva/induzido quimicamente , Injeções , Injeções Intraperitoneais , Masculino , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Fatores de Tempo
7.
J Craniofac Surg ; 24(5): 1716-9, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24036762

RESUMO

OBJECTIVE: This study evaluated the outcome in adult patients with laryngotracheal stenosis (LTS) and assessed the effect of procedures on their quality-of-life scores. METHODS: The study included 15 adult patients with LTS (11 males [73.3%], 4 females [26.7%]; mean age, 32 years [range, 10-52 years]) treated at the Department of Otolaryngology Head and Surgery Clinic, Izmir Atatürk Research Hospital, Turkey, from 1997 to 2008. Success of the surgery is evaluated by decanullation rate, Short form-36 (SF-36), and the Medical Research Council dyspnea scale. RESULTS: The etiology of the LTS was intubation related in 14 cases (93.3%) and idiopathic in 1 case. According to the Myers-Cotton classification, 2 (13%), 8 (54%), and 5 (33%) patients were at stages 2 to 4, respectively. Fourteen patients had a mean follow-up of 57 months (range, 24-256 months). The stenotic segment involved 1 to 3 cm (mean, 1.7 cm) of trachea, and 2 to 5 tracheal rings (mean, 3.1) were resected. Postoperative decannulation was achieved in 13 patients (86.6%). In the short form-36 questionnaire, all of the parameters except for "role-emotional" were found to be significant (P < 0.01). The Medical Research Council dyspnea scale assessment revealed a significant (P < 0.001) decrease postoperatively. CONCLUSIONS: Segmental resection with primary anastomosis is an effective method and can be used as the first option in selected cases of advanced stenosis.


Assuntos
Intubação Intratraqueal/efeitos adversos , Laringoestenose/cirurgia , Estenose Traqueal/cirurgia , Adolescente , Adulto , Criança , Constrição Patológica , Feminino , Humanos , Laringoestenose/etiologia , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Qualidade de Vida , Estenose Traqueal/etiologia , Turquia , Adulto Jovem
8.
Kulak Burun Bogaz Ihtis Derg ; 23(1): 15-20, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23521407

RESUMO

OBJECTIVES: This study aims to evaluate the complications of tracheoesophageal puncture (TEP) for voice restoration and speech valves in patients undergoing total laryngectomy. PATIENTS AND METHODS: Between January 2006 and June 2011, 47 male patients (mean age 62.8±1.2 years; range 41 to 80 years) who underwent TEP and speech valve for voice restoration after total laryngectomy were retrospectively analyzed. Secondary TEP was performed and Provox indwelling voice prosthesis were inserted in all patients. Demographic, disease and treatment characteristics of patients were recorded. Complications related to TEP and speech valves, the management of complications and clinical conditions of complete closure of TEP were also recorded. RESULTS: Tracheoesophageal puncture and speech valve related complications were observed in 20 patients. The majority of complications were minor complications including granulation tissue formation (n=2, 4.2%), deglutition of prosthesis (n=6, 12.7%) and TEP enlargement/leakage around prosthesis (n=9, 19.1%). Major complications were observed in three patients. Two of them were life-threatening complications; a mediastinitis (n=1, 3.1%) and paraesophageal abscess (n=1, 3.1%), and both appeared in the first month of the postoperative period. The overall complication rate was 42.6% during mean follow-up of 15.3 months. Tracheoesophageal fistula enlargement (n=9, 19.1%) was the most common minor complication and the most common cause of complete closure of TEP in this study. CONCLUSION: Tracheoesophageal puncture for voice restoration is not an entirely innocent procedure without any complications. Patients should be monitored for TEP-related complications in the early and late postoperative period.


Assuntos
Esôfago/cirurgia , Laringectomia/efeitos adversos , Laringe Artificial/efeitos adversos , Punções/efeitos adversos , Traqueia/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/secundário , Carcinoma de Células Escamosas/cirurgia , Neoplasias de Cabeça e Pescoço/secundário , Humanos , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Voz Esofágica/métodos
9.
Kulak Burun Bogaz Ihtis Derg ; 22(6): 348-53, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23176700

RESUMO

Synovial sarcomas (SS) account for 7-8% of soft-tissue cancers and 3-5% of all cases with head and neck involvement. Synovial sarcoma of the infratemporal fossa is very rare In this article, we report the fourth case of SS of infratemporal fossa and the first case with intracranial extension via the foramen ovale. A 31-year-old man admitted with a one-year history of intense pain in his right jaw. On physical examination, there was only hyperesthesia over the right mandible side. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a mass in the infratemporal fossa and intracranial extension from the foramen ovale. The mass was surgically removed en bloc. Postoperative pathological examination reported the mass as a biphasic-type synovial sarcoma. The patient who received postoperative chemoradiotherapy had no recurrent disease for one year. The patient is still being followed in our clinic.


Assuntos
Sarcoma Sinovial/patologia , Neoplasias Cranianas/patologia , Osso Esfenoide , Osso Temporal , Adulto , Quimiorradioterapia Adjuvante , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Masculino , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/cirurgia , Sarcoma Sinovial/terapia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/cirurgia , Neoplasias Cranianas/terapia , Osso Esfenoide/patologia , Osso Temporal/patologia , Articulação Temporomandibular/patologia , Tomografia Computadorizada por Raios X
10.
Eur Arch Otorhinolaryngol ; 267(5): 673-7, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-19771442

RESUMO

Tympanosclerosis is a sequel of chronic otitis media characterized by the deposition of calcareous plaques following hyaline degeneration in the fibrous layer of the tympanic membrane and inside middle ear mucosa. It usually results from prior middle ear infections. In this study, results of treatment and clinical findings of the patients with tympanosclerosis are presented. Our objective is to determine the changes in middle ear caused by tympanosclerosis and intervene in the more problematic zone and find out the more useful treatment protocol for patients. Preoperative features, middle ear findings detected during surgery and postoperative hearing levels of the patients who were operated in our clinic between January 1996 and June 2006 due to tympanosclerosis were evaluated. Surgical treatment was performed on a total of 37 patients including 25 females and 12 males between ages of 11 and 71. Preoperative tympanic membranes perforations were presented at a rate of 91% and average airway bone gap was 37.8 dB. Bilateral involvement was present in 59%. Conductive-type hearing loss was present at a rate of 81%, whereas mixed-type hearing existed at a rate of 19%. Sclerotic plaques were most commonly localized in the attic with a rate of 72%. Post-op outcome was found to be 27% in the patients with air bone gap between 0-20 dB. The best hearing result belonged to type 1 patients. Cases in which stapes footplate was fixated had the worst result in terms of hearing. Teflon piston was only applied in one patient. Our tympanoplasty success was found to be 67%. The most common treatment method of tympanosclerosis is surgery. Stapedectomy is recommended in surgery instead of mobilization techniques. However, there is often recurrence and there is no curative treatment. Therefore rehabilitation with hearing device can be preferred as an adjunct. In the recent experimental studies, good results with topical or systemic agents have also been promising.


Assuntos
Procedimentos Cirúrgicos Otológicos/métodos , Membrana Timpânica/patologia , Membrana Timpânica/cirurgia , Adolescente , Adulto , Idoso , Criança , Doença Crônica , Feminino , Perda Auditiva Condutiva/diagnóstico , Perda Auditiva Condutiva/etiologia , Perda Auditiva Condutiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa/patologia , Otite Média/complicações , Cuidados Pré-Operatórios/estatística & dados numéricos , Esclerose/etiologia , Esclerose/patologia , Esclerose/cirurgia , Perfuração da Membrana Timpânica/complicações , Perfuração da Membrana Timpânica/epidemiologia , Adulto Jovem
11.
Eur Arch Otorhinolaryngol ; 267(5): 715-20, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-19851778

RESUMO

Nasal breathing is completely ceased after total laryngectomy. This results in some structural changes in the nasal mucosa, which has been described in numerous studies. This study investigates the changes that appear in the paranasal sinus mucosa. Eight patients who had undergone total laryngectomy at least 1-year ago were enrolled. Under general anesthesia, maxillary sinuses were examined with an endoscope inserted through canine fossa. 1-2 mm mucosal tissues for biopsy were taken from posterior wall of the maxillary sinus. Specimens were evaluated under an electron microscope. Control tissues for biopsy were obtained from two patients who had been operated for other reasons and analyzed under transmission electron microscopy. Results showed that in the control specimens, the epithelial cells appeared normal under transmission electron microscopy. Samples taken from two larygectomees in their first postoperative year were also completely normal. Samples from other larygectomees demonstrated ciliary loss, abundant degenerative vacuoles in ciliated epithelial cells and detachments in the interepithelial junctional complexes. The intracellular respiratory mechanisms such as the mitochondria, golgi complex and endoplasmic reticulum cisternae, and the integrity of the cellular or the nuclear membrane were spared. We conclude that the cessation of nasal breathing resulted in degenerative changes that could be reversible in the transmission electron microscopic examination of maxillary sinus mucosa. These changes emerged after 2 years following total laryngectomy. Nevertheless, these changes did not have any negative influence on the clinical outcome in this group of patients.


Assuntos
Laringectomia , Seio Maxilar/ultraestrutura , Microscopia Eletrônica/métodos , Mucosa Nasal/ultraestrutura , Animais , Cães , Humanos , Respiração
12.
Eur Arch Otorhinolaryngol ; 266(1): 117-20, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18542980

RESUMO

We evaluated the risk of occult contralateral neck involvement according to T stage and ipsilateral neck stage in centrally located supraglottic laryngeal cancer. The side largely involved by the tumor was defined as ipsilateral and the other side was defined as contralateral in terms of the neck dissection side. We retrospectively analyzed clinical and pathologic data from a group of 189 centrally located supraglottic cancer patients in which bilateral neck dissection was part of the primary treatment. Among 378 neck dissection specimens, the rate of bilateral metastasis was 33/189 (17.5%). The rate of occult metastases in the contralateral side were 33/75 (44%) and 6/114 (5.3%), when ipsilateral neck was pN+ and pN-, respectively. Clinically or pathologically positive ipsilateral nodes and the extracapsular spread in the ipsilateral positive nodes displayed significantly higher risk of contralateral metastases. The incidence of occult contralateral metastases did not seem to be affected significantly by T stage of the tumor. Our retrospective study confirmed that the probabilistic criteria of the incidence of contralateral occult metastases in supraglottic laryngeal cancer with tumor largely involving one side and crossing the midline. On the basis of our data, there is a high prevalence of contralateral metastases in tumors with clinically or pathologically positive ipsilateral lymph nodes. The extracapsular spread of the nodes is also an important determinant of the contralateral involvement.


Assuntos
Carcinoma de Células Escamosas/secundário , Glote/patologia , Neoplasias Laríngeas/patologia , Linfonodos/patologia , Recidiva Local de Neoplasia/patologia , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/cirurgia , Distribuição de Qui-Quadrado , Estudos de Coortes , Feminino , Humanos , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/cirurgia , Laringectomia/métodos , Linfonodos/cirurgia , Metástase Linfática , Masculino , Esvaziamento Cervical , Invasividade Neoplásica/patologia , Recidiva Local de Neoplasia/mortalidade , Estadiamento de Neoplasias , Probabilidade , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
13.
Eur Arch Otorhinolaryngol ; 266(5): 663-7, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-18795310

RESUMO

This study analyzed the ototoxic effects of boric acid solutions. Boric acid solutions have been used as otologic preparations for many years. Boric acid is commonly found in solutions prepared with alcohol or distilled water but can also be found in a powder form. These preparations are used for both their antiseptic and acidic qualities in external and middle ear infections. We investigated the ototoxic effect of boric acid solutions on guinea pigs. We are unaware of any similar, previously published study of this subject in English. The study was conducted on 28 young albino guinea pigs. Prior to application of the boric acid solution under general anesthesia, an Auditory Brainstem Response (ABRs) test was applied to the right ear of the guinea pigs. Following the test, a perforation was created on the tympanic membrane of the right ear of each guinea pig and small gelfoam pieces were inserted into the perforated area. Test solutions were administered to the middle ear for 10 days by means of a transcanal route. Fifteen days after inserting the gelfoams in all of the guinea pigs, we anasthesized the guinea pigs and removed the gelfoams from the perforated region of the ear and then performed an ABRs on each guinea pig. The ABRs were within the normal range before the applications. After the application, no significant changes were detected in the ABRs thresholds in neither the saline group nor the group administered boric acid and distilled water solution; however, significant changes were detected in the ABRs thresholds of the Gentamicine and boric acid and alcohol solution groups. We believe that a 4% boric acid solution prepared with distilled water can be a more reliable preparation than a 4% boric acid solution prepared with alcohol.


Assuntos
Ácidos Bóricos/efeitos adversos , Otopatias/induzido quimicamente , Orelha Média/efeitos dos fármacos , Inseticidas/efeitos adversos , Animais , Limiar Auditivo , Ácidos Bóricos/administração & dosagem , Otopatias/diagnóstico , Potenciais Evocados Auditivos do Tronco Encefálico , Cobaias , Inseticidas/administração & dosagem , Masculino , Soluções
14.
Eur Arch Otorhinolaryngol ; 266(11): 1681-6, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19756681

RESUMO

The purpose of this report is to review the experience of our institution with conservative surgery for laryngeal cancer. In this retrospective study, a review was made of 85 patients treated with conservation surgery between 1998 and 2005. At least 2 years of follow-up period (mean 46.6 months) was achieved for all the patients. We evaluated age, tobacco and alcohol intake, T stage, histopathological differentiation and localization of tumor, subglottic extension, anterior commissure invasion, vocal cord mobility, surgical margins, type of surgery applied, and post-operative radiotherapy (pRT) applied. Local control and 2-year survival rates were estimated. We managed with horizontal, vertical, and horizontovertical laryngectomies in 55, 26, and 4 patients, respectively. 28 patients were scheduled to have pRT. The actuarial and overall local control rates were 82.4 and 94.1%, respectively. On univariable analysis, significant factors for increased recurrences were positive resection margins, low differentiation of tumor, alcohol consumption and incompletion of the planned pRT. The 2-year survival rate was 60 and 95.7% for patients with and without local recurrence, respectively. Conservation surgery is a safe procedure for laryngeal cancer in proper endications.


Assuntos
Carcinoma/cirurgia , Neoplasias Laríngeas/cirurgia , Laringectomia , Recidiva Local de Neoplasia/epidemiologia , Adulto , Idoso , Carcinoma/mortalidade , Carcinoma/patologia , Estudos de Coortes , Humanos , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/patologia , Masculino , Pessoa de Meia-Idade , Radioterapia Adjuvante , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
15.
Kulak Burun Bogaz Ihtis Derg ; 19(3): 146-50, 2009.
Artigo em Turco | MEDLINE | ID: mdl-19857193

RESUMO

OBJECTIVES: The aim of this study is to evaluate risk factors for stomal recurrence and to state and emphasize the importance of these factors. PATIENTS AND METHODS: This study was carried out retrospectively on 119 patients (116 males, 3 females; mean age 56.8 years; range 31 to 86 years) with larynx cancer who underwent total laryngectomy. All patients were examined for T-stage and location of primary tumor, tracheotomy (preoperative or postoperative) opening time, modality of applied treatment, presence of pharyngeal stoma fistula and presence of cervical lymph node metastasis in the postoperative period. RESULTS: Five patients (4.2%) out of 119 had stomal recurrence. Development period of stomal recurrence after laryngectomy was found to be between six months and three years (mean: 16.6 months). CONCLUSION: The treatment of this fatal complication is very difficult, and it has a poor prognostic nature. As a result, presence of subglottic involvement and advanced tumors in our cases are considered as main risk factors.


Assuntos
Laringectomia/efeitos adversos , Recidiva Local de Neoplasia/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/mortalidade , Recidiva Local de Neoplasia/cirurgia , Prognóstico , Fatores de Risco
16.
Otolaryngol Head Neck Surg ; 136(2): 291-5, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17275557

RESUMO

OBJECTIVE: This study evaluates the vocal cord and arytenoid mobility in relation to the tumoral involvement of the cricoarytenoid joint (CAJ), thyroarytenoid (TA) muscle, and posterior cricoarytenoid (PCA) muscle in whole-organ sections of total laryngectomy specimens. STUDY DESIGN AND SETTING: The study was prospectively carried out between 1998 and 2003 and involved 133 primary squamous cell carcinoma cases of larynx or pyriform sinus that were treated with total laryngectomy. Preoperative mobility of vocal cords and arytenoids were evaluated separately and correlated with histopathologic findings. RESULTS: In cases with fixed vocal cord CAJ, TA muscle, and PCA muscle were involved in 42.4%, 72.9%, and 27.1% of the cases, respectively, while in cases with fixed arytenoid these structures were affected in 40%, 66.3%, and 25.3% of the cases. Weight effect seemed to play a role in 60% and 50% of the cases of supraglottic and pyriform sinus carcinoma, respectively. CONCLUSION: Careful evaluation of the mobility of the cord arytenoid unit separately helps the surgeon to better understand the patterns of tumoral extension guiding for the appropriate surgery which should be undertaken.


Assuntos
Cartilagem Aritenoide/patologia , Carcinoma de Células Escamosas/patologia , Neoplasias Hipofaríngeas/patologia , Neoplasias Laríngeas/patologia , Prega Vocal/patologia , Carcinoma de Células Escamosas/cirurgia , Humanos , Neoplasias Hipofaríngeas/cirurgia , Neoplasias Laríngeas/cirurgia , Laringectomia , Invasividade Neoplásica , Estudos Prospectivos
17.
Acta Otolaryngol ; 127(11): 1202-6, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17851904

RESUMO

CONCLUSION: Dissecting levels 2 and 3 and sparing the dissection of level 4 and the contralateral neck when frozen section results are negative are reasonable options for the selective dissection of cN0 necks. Our findings show that dissection of level 5 is considered unnecessary, unless there is overt metastasis. OBJECTIVE: The level of node involvement and recurrence rates were assessed in cN0 laryngeal and hypopharyngeal carcinoma patients in order to develop appropriate guidelines for the treatment of the neck. MATERIALS AND METHODS: A total of 328 cN0 necks operated with selective dissection were reviewed retrospectively. Patients were monitored for at least 24 months and regional recurrences were evaluated. RESULTS: The prevalence of level 4 occult metastases was 3.4%; 1.5% of them were isolated to level 4. We observed regional recurrence in 5.6% of the necks. No case of metastasis or regional relapse was observed in level 5.


Assuntos
Neoplasias Hipofaríngeas/cirurgia , Neoplasias Laríngeas/cirurgia , Excisão de Linfonodo/métodos , Esvaziamento Cervical/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Neoplasias Hipofaríngeas/secundário , Neoplasias Laríngeas/secundário , Linfonodos/patologia , Linfonodos/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Estudos Retrospectivos , Resultado do Tratamento
18.
Acta Otolaryngol ; 136(9): 933-6, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27092981

RESUMO

OBJECTIVES: To present retrospective experience in Meyer-Cotton grade 3 tracheal stenosis of 17 patients treated by T-tube, considering the characteristics of the treated stenosis, surgical procedures performed, and post-operative outcomes and complications. METHODS: All demographic and clinical data were collected retrospectively. Chest and neck computed tomography scans were performed to assess the stenosis, including length, location, and glottic involvement. The stenotic area was evaluated endoscopically according to an adapted Meyer and Cotton grading scale. RESULTS: The aetiology of the tracheal stenosis was intubation-related in all cases. The duration of intubation ranged between 1 hour to 40 days. According to the Myers-Cotton classification, all patients were at stage 3. Mean length of the stenosis was 26.58 ± 12.02 (range =15-70) mm. Mean follow-up for the study group was 60.16 ± 34.10 (range =18-137) months. Two patients died during follow-up, one due to stroke, one due to chronic lymphocytic leukemia; no deaths were attributable to TS. The remaining 15 patients could be evaluated up to the present time. Post-operative decannulation was achieved in three of 15 patients (20%), and decannulation was not achieved in 12 of 15 patients (80%). CONCLUSION: T-tube is not an effective treatment of tracheal stenosis.


Assuntos
Laringoscopia/instrumentação , Estenose Traqueal/terapia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Falha de Tratamento , Adulto Jovem
19.
Otolaryngol Head Neck Surg ; 155(5): 797-804, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27221573

RESUMO

OBJECTIVE: We investigated the value of lymph node density (LND) as a predictor of survival in patients with laryngeal squamous cell carcinoma (SCC) and positive neck node (pN+) after laryngectomy. STUDY DESIGN: Case series with chart review. SETTING: Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. SUBJECTS AND METHODS: We reviewed the records of 289 patients with newly diagnosed primary laryngeal carcinomas who underwent partial or total laryngectomy and combined neck dissection at a tertiary referral center between June 2006 and December 2014. Patients with pN+ laryngeal SCC (n = 101) were included in the study. Overall survival (OS) and disease-free survival (DFS) were used to evaluate the prognostic significance of LND. RESULTS: In 101 patients with pN+ laryngeal SCC, LND ≥0.09 and number of metastatic lymph nodes >4 were significantly associated with OS and DFS but not the overall tumor, node, and metastasis stage. Forward stepwise Cox regression analysis revealed that LND ≥0.09 was the only independent predictor of both DFS and OS. Furthermore, the odds ratio of LND ≥0.09 was 10 times higher in patients with regional recurrence when compared patients without regional recurrence. CONCLUSIONS: LND was the only independent prognostic predictor of OS and DFS in patients with pN+ laryngeal SCC. Moreover, patients with LND ≥0.09 were significantly associated with high risk of regional recurrence. Thus, patients with LND ≥0.09 are at high risk of regional recurrence and death and may be considered for adjuvant chemoradiation.


Assuntos
Neoplasias Laríngeas/patologia , Metástase Linfática/patologia , Adulto , Idoso , Feminino , Humanos , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/cirurgia , Laringectomia , Masculino , Pessoa de Meia-Idade , Esvaziamento Cervical , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida , Turquia/epidemiologia
20.
Clin Dermatol ; 32(1): 141-52, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24314388

RESUMO

The external ear is composed of the auricle (pinna) and the external auditory canal. Both of these structures contain elastic cartilage (except the earlobe) and a small amount of subcutaneous fat, which are covered by skin. The skin of the cartilaginous canal contains hair cells, sebaceous (lipid-producing) glands, and apocrine (ceruminous) glands; this is in contrast with the osseous canal, which contains neither glands nor hair follicles. The auricle is susceptible to environmental influences and trauma. Due to its exposed locale, the ear is particularly vulnerable to the effects of ultraviolet light and, consequently, to preneoplastic and neoplastic skin lesions. The ear also has a sound-receiving function and a location that is both visible and aesthetically obvious, thereby drawing considerable attention from the patient. Dermatologic diseases on the external ear are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, family practitioners, and general and plastic surgeons are regularly consulted about cutaneous lesions on the ear. These lesions can be grouped into three main categories: (1) infectious; (2) tumoral; and (3) noninfectious inflammatory. The purposes of this contribution are to review various dermatologic diseases of the external ear and to update current diagnosis and treatment information related to these conditions.


Assuntos
Otopatias/diagnóstico , Otopatias/terapia , Orelha Externa , Dermatopatias/diagnóstico , Dermatopatias/terapia , Doença de Bowen/diagnóstico , Queimaduras/terapia , Carcinoma Basocelular/diagnóstico , Congelamento das Extremidades/terapia , Humanos , Melanoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/terapia
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