tert-butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model.

tert-butyl hydroperoxide (tBHP), an organic peroxide, has been shown to cause irreversible damage to keratinocytes in vitro with prolonged administration at high concentrations, and reversible damage with short-term administration at low concentrations. To investigate the effects of tBHP on keratinocytes in vivo, we analysed hair growth in tBHP-treated neonatal rats. Sprague-Dawley and Long-Evans rat pups were injected subcutaneously with tBHP or vehicle once daily for 6 days, and hair growth was monitored. The tBHP-treated rats had a significant delay in hair growth. However, this delay reversed within days, and the hair coats, including hair pigmentation, of tBHP-treated and sham-treated rats were indistinguishable 2 weeks later. Histological analysis and BrdU labelling of S phase cells confirmed the delay in hair-follicle growth and its reversal in tBHP-treated rats. Our results indicated that the changes incurred in hair follicles by short-term use of high-dose oxidants in vivo are temporary and reversible.

Ahmed glaucoma drainage implant surgery in the management of refractory uveitic glaucoma: Long-term follow up. / Implante de válvula de Ahmed para el manejo del glaucoma uveítico refractario: seguimiento a largo plazo.

OBJECTIVE: To examine the long-term efficacy, safety and complications of Ahmed glaucoma drainage implant surgery in patients with refractory uveitic glaucoma. METHODS: Retrospective review of consecutive cases of patients with refractory uveitic glaucoma who underwent Ahmed glaucoma drainage implant surgery between 2004-2014. Demographic characteristics of the study population, visual acuity, intraocular pressure (IOP), number of antiglaucoma medications and operative and postoperative complications were recorded. Complete success was defined as IOP≥5 and ≤18mmHg without any medication, as qualified success if IOP≤18mmHg with one or more medications. Patients with less than 12 months of follow-up were excluded. RESULTS: 21 patients (26 eyes) were included. The mean postoperative follow-up was 53.5±31 months. Eight eyes (30%) had at least one previously failed glaucoma surgery. IOP was reduced from a mean of 30.0mmHg to 14.0mmHg at the last follow-up visit (P<.001). The number of IOP-lowering medications was reduced from a median of 2.9 preoperatively to 1.1 at the last follow-up (P<.001). Overall, 7 eyes (27%) were classified as complete success, 13 eyes (50%) were considered as qualified success, and 6 eyes (23%) met the criteria for failure. The most common postoperative complication was hypertensive phase in 12 eyes (46%). Kaplan-Meier life-table analysis showed a cumulative probability of success after Ahmed glaucoma valve implantation of 65% at 84 months. CONCLUSIONS: Ahmed glaucoma drainage implant surgery may be considered a long-term effective and safety surgical option for patients with refractory uveitic glaucoma.

[Granular cell tumor. A lingual case report]. / Tumor de células granulares. A propósito de un caso lingual.

Although the origin of granular cell tumor (GCT) is no totally clarified, a neurogenic source is generally accepted. Some think its forerunners are the Schwann cells. Despite the tongue's localisation is frequently seen, few are the papers dealing with this topic. We report the case of a patient suffering a granular cell tumor of the tongue and profit the opportunity to reconsider the followings items: clinical findings, examination, diagnosis, histology and management and course of these growths. Literature's review of the theme.

[Chronic cholesteatomatous otitis media: comparison of otoscopic, computed tomographic and surgical findings]. / Otitis media crónica colesteatomatosa: comparación de la otoscopia y TC frente a los hallazgos quirúrgicos.

A retrospective study was made of 43 patients diagnosed as chronic otitis media, with and without cholestatoma, who were treated with surgical tympanoplasty. Otoscopic and computed tomographic findings were analyzed and correlated with surgical findings in order to evaluate the diagnostic value of scans.

[Protruding jugular bulb. A review of 7 cases]. / Golfo yugular procidente. Revisión de siete casos.

The position of the jugular bulb varies greatly. A high jugular bulb procident from the temporal bone is not uncommon. Most people with this anatomic variation remain asymptomatic. We report seven cases of high jugular bulb with clinical manifestations. The anatomy, clinical manifestations, diagnosis, and management are reviewed.

[Therapeutic approach to peritonsillar abscesses]. / Nuestra actitud terapéutica ante el absceso periamigdalino.

The treatment of peritonsillar abscesses is debated. A retrospective study was made of 19 patients diagnosed as peritonsillar abscess who were treated by incision, drainage, and intravenous antibiotics. The surgical, medical and diagnosis factors that affect the management of peritonsillar abscesses are discussed.