RESUMO
The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.
RESUMO
BACKGROUND AND OBJECTIVE: Essential arterial hypertension (HTA) and metabolic syndrome (MS) are highly prevalent disorders, with familiar aggregation and important mortality. Late HTA diagnosis is made in a high percentage of people. The aim of this study was to diagnose HTA among hypertensive and MS patients' children. PATIENTS AND METHOD: Hypertensive and MS patients attended at primary and hypertension clinics were studied. Hypertensive patients collaborated to get their children's blood pressure measured. If high blood pressure was detected, the patients' children were referred to their family doctor in order to confirm the diagnosis of HTA. RESULTS: 118 hypertensive patients were studied. Blood pressure was measured in 117 hypertensive patients' children. Thirty-two of them (27.4%) had blood pressure > or = 130/85 mmHg. Eventually, 20 of them (62.5%) were diagnosed of HTA. 17% of the hypertensive patients' children studied were newly diagnosed of HTA. CONCLUSIONS: Screening for HTA among hypertensive and MS patients' children is useful for early diagnosis or HTA and it is cost-effective.