Detalhe da pesquisa
1.
Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase.
J Enzyme Inhib Med Chem
; 38(1): 2231169, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37401012
2.
Phenotypic and Target-Directed Screening Yields New Acaricidal Alternatives for the Control of Ticks.
Molecules
; 27(24)2022 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36557996
3.
A strategy based on thermal flexibility to design triosephosphate isomerase proteins with increased or decreased kinetic stability.
Biochem Biophys Res Commun
; 503(4): 3017-3022, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143261
4.
Differential effects on enzyme stability and kinetic parameters of mutants related to human triosephosphate isomerase deficiency.
Biochim Biophys Acta Gen Subj
; 1862(6): 1401-1409, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29571745
5.
The effect of specific proline residues on the kinetic stability of the triosephosphate isomerases of two trypanosomes.
Proteins
; 85(4): 571-579, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002620
6.
A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease.
Proteins
; 85(7): 1190-1211, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28378917
7.
Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp.
Molecules
; 22(5)2017 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28481276
8.
3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies.
Molecules
; 20(8): 14595-610, 2015 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26274947
9.
Different contribution of conserved amino acids to the global properties of triosephosphate isomerases.
Proteins
; 82(2): 323-35, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23966267
10.
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
J Enzyme Inhib Med Chem
; 29(2): 198-204, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23406473
11.
1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.
J Enzyme Inhib Med Chem
; 28(5): 981-9, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22803666
12.
Pyrazol(in)e derivatives of curcumin analogs as a new class of anti-Trypanosoma cruzi agents.
Future Med Chem
; 13(8): 701-714, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33648346
13.
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana.
Front Cell Infect Microbiol
; 11: 641356, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33937094
14.
Native aggregation is a common feature among triosephosphate isomerases of different species.
Sci Rep
; 10(1): 1338, 2020 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992784
15.
Medical and Veterinary Importance of the Moonlighting Functions of Triosephosphate Isomerase.
Curr Protein Pept Sci
; 20(4): 304-315, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30370845
16.
Key within-membrane residues and precursor dosage impact the allotopic expression of yeast subunit II of cytochrome c oxidase.
Mol Biol Cell
; 30(18): 2358-2366, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318312
17.
The conserved salt bridge linking two C-terminal beta/alpha units in homodimeric triosephosphate isomerase determines the folding rate of the monomer.
Proteins
; 72(3): 972-9, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18300228
18.
Expression, purification and preliminary X-ray diffraction studies of the transcriptional factor PyrR from Bacillus halodurans.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 8): 692-6, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678934
19.
Three unrelated and unexpected amino acids determine the susceptibility of the interface cysteine to a sulfhydryl reagent in the triosephosphate isomerases of two trypanosomes.
PLoS One
; 13(1): e0189525, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342154
20.
Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity.
Vet Sci
; 5(3)2018 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30142944