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Herein, the design and development of a new one-pot and metal-free oxidative C-H activation/aza-Prins type cyclization of alkynylamines is reported. The scope of this method was demonstrated by the preparation of ten new pyrido[2,1-a]isoquinolines in moderate to high yields (38-92%). Furthermore, a mechanistic proposal for the alkyne aza-Prins cyclization is described based on DFT calculations.
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PURPOSE: To assess complications of hip endoscopy in patients with subgluteal space pathologies. METHODS: This was a retrospective study of patients diagnosed with sciatic nerve entrapment (SNE), ischiofemoral impingement (IFI), and rupture of the proximal origin of the hamstring muscles (RHM) who underwent a hip endoscopy from January 2012 to December 2018, after a minimum of 3 months of conservative management without satisfactory results. Complications were documented and graded using the adapted system of Clavien-Dindo. Revision surgeries were classified as treatment failures. Function was evaluated by the Western Ontario McMaster Universities Osteoarthritis Index before and 12 months after the surgical procedure. RESULTS: A total of 97 hips with subgluteal space pathologies were treated with hip endoscopy. This total consisted of 77 hips with SNE, 5 with IFI, 12 with SNE + IFI, and 3 hips with RHM. Minor (Clavien-Dindo I-II) and major (Clavien-Dindo III-V) complications occurred in 7.22% (7) (95% confidence interval 3.54%-14.15%) and 12.37% (12) (95% confidence interval 7.22%-20.39%). Grade II, III, and IV complications were reported in 7.22% (7), 7.22%, and 5.15% (5) hips, respectively. Temporary nerve injury of the sciatic nerve, hematoma, and permanent nerve injury of the posterior femoral cutaneous nerve were the most common grade II, grade III, and grade IV complications, respectively. The revision rate was 6.19% (6) and entrapment of the sciatic nerve was the main cause of reoperation. No statistically significant differences were found between cases with and without complications in the Western Ontario McMaster Universities Osteoarthritis Index scores evaluated before and after surgery (P > .05). CONCLUSIONS: A high rate of complications associated with hip endoscopy were observed in patients with SNE, IFI, and RHM. Sciatic nerve and posterior femoral cutaneous nerve injury were the most frequent events. LEVEL OF EVIDENCE: IV, case series type.
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Artroplastia de Quadril , Luxação do Quadril , Endoscopia , Luxação do Quadril/cirurgia , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/cirurgia , Humanos , Reoperação , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: Ischiofemoral impingement is considered to be an uncommon and difficult pathology to diagnose with respect to hip pain etiology. The objective was to describe the clinical results of endoscopic lesser trochanter resection via a posterior approach in patients with Ischiofemoral impingement. METHODS: This was a retrospective observational study of consecutive patients with Ischiofemoral impingement, who underwent endoscopic resection of the lesser trochanter via a posterior approach, between 2015 and 2018. Clinical results were evaluated using the ischiofemoral impingement test, long-stride walking test, modified Harris Hip Score (mHHS) and the Oxford scale to assess the strength of the iliopsoas muscle as well as the presence of complications. Preoperative and postoperative ischiofemoral space was measured to assess whether the resection of the lesser trochanter was adequate. RESULTS: 16 hips in 13 patients (mean age: 34.4 ± 12.1 years, 11 women) with a follow-up period between 24 and 59 months were included. Preoperative ischiofemoral space ranged from 6.4 to 22.4 mm, a measure > 17.0 mm was achieved in 15 hips without the presence of pain in IFI test and long-strides walking test. Function improved postoperatively, as reflected by a higher mean mHHS (preoperative: 44.6 ± 21.5, postoperative: 81.2 ± 15.1, p < 0.05). After surgery, the strength of the iliopsoas muscle was not decreased compared to the preoperative measure. Three complications were reported, including two cases that required revision surgery. CONCLUSIONS: Endoscopic resection of the lesser trochanter via posterior approach provides satisfactory outcomes with symptom relief and good functional results in patients with Ischiofemoral impingement. It is important to discuss the benefits and risks when offering this treatment choice. LEVEL OF EVIDENCE: Level IV.
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Impacto Femoroacetabular , Quadril , Artralgia , Pré-Escolar , Endoscopia , Feminino , Impacto Femoroacetabular/cirurgia , Fêmur/cirurgia , Articulação do Quadril , Humanos , DorRESUMO
Lane detection for traffic surveillance in intelligent transportation systems is a challenge for vision-based systems. In this paper, a novel pixel-entropy based algorithm for the automatic detection of the number of lanes and their centers, as well as the formation of their division lines is proposed. Using as input a video from a static camera, each pixel behavior in the gray color space is modeled by a time series; then, for a time period τ , its histogram followed by its entropy are calculated. Three different types of theoretical pixel-entropy behaviors can be distinguished: (1) the pixel-entropy at the lane center shows a high value; (2) the pixel-entropy at the lane division line shows a low value; and (3) a pixel not belonging to the road has an entropy value close to zero. From the road video, several small rectangle areas are captured, each with only a few full rows of pixels. For each pixel of these areas, the entropy is calculated, then for each area or row an entropy curve is produced, which, when smoothed, has as many local maxima as lanes and one more local minima than lane division lines. For the purpose of testing, several real traffic scenarios under different weather conditions with other moving objects were used. However, these background objects, which are out of road, were filtered out. Our algorithm, compared to others based on trajectories of vehicles, shows the following advantages: (1) the lowest computational time for lane detection (only 32 s with a traffic flow of one vehicle/s per-lane); and (2) better results under high traffic flow with congestion and vehicle occlusion. Instead of detecting road markings, it forms lane-dividing lines. Here, the entropies of Shannon and Tsallis were used, but the entropy of Tsallis for a selected q of a finite set achieved the best results.
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BACKGROUND: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in limited-resources settings where laboratory facilities are scarce. This study aimed to develop a risk score for prevalent undiagnosed CKD using data from four settings in Peru: a complete risk score including all associated risk factors and another excluding laboratory-based variables. METHODS: Cross-sectional study. We used two population-based studies: one for developing and internal validation (CRONICAS), and another (PREVENCION) for external validation. Risk factors included clinical- and laboratory-based variables, among others: sex, age, hypertension and obesity; and lipid profile, anemia and glucose metabolism. The outcome was undiagnosed CKD: eGFR < 60 ml/min/1.73m2. We tested the performance of the risk scores using the area under the receiver operating characteristic (ROC) curve, sensitivity, specificity, positive/negative predictive values and positive/negative likelihood ratios. RESULTS: Participants in both studies averaged 57.7 years old, and over 50% were females. Age, hypertension and anemia were strongly associated with undiagnosed CKD. In the external validation, at a cut-off point of 2, the complete and laboratory-free risk scores performed similarly well with a ROC area of 76.2% and 76.0%, respectively (P = 0.784). The best assessment parameter of these risk scores was their negative predictive value: 99.1% and 99.0% for the complete and laboratory-free, respectively. CONCLUSIONS: The developed risk scores showed a moderate performance as a screening test. People with a score of ≥ 2 points should undergo further testing to rule out CKD. Using the laboratory-free risk score is a practical approach in developing countries where laboratories are not readily available and undiagnosed CKD has significant morbidity and mortality.
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Insuficiência Renal Crônica/diagnóstico , Insuficiência Renal Crônica/epidemiologia , Índice de Gravidade de Doença , Adulto , Idoso , Estudos de Coortes , Estudos Transversais , Feminino , Seguimentos , Humanos , Hipertensão/diagnóstico , Hipertensão/epidemiologia , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Peru/epidemiologia , Prevalência , Insuficiência Renal Crônica/fisiopatologia , Fatores de RiscoRESUMO
A highly efficient metal-free catalytic system for the aerobic photocyanation of tertiary amines with visible light is reported. The use of air as terminal oxidant offers an improved safety profile compared with pure oxygen, the used compact fluorescent lamp (CFL) light sources are highly economical, and no halogenated solvents are required. This system not only proves to be effective for a wide variety of trialkylamines, pharmaceuticals, and alkaloids but remarkably also allows the lowest catalyst loading (0.00001 mol% or 0.1 ppm) ever reported for an organic dye. Bruylants reactions and C-alkylation/decyanations were performed on the obtained α-aminonitriles to demonstrate the postfunctionalization of complex molecules. The catalytic system is furthermore applied in the short and effective syntheses of the alkaloids (±)-crispine A and the tetraponerines T7 and T8.
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Alcaloides/química , Aminas/química , Isoquinolinas/síntese química , Metais/química , Alquilação , Catálise , Isoquinolinas/química , Luz , Estrutura Molecular , OxirreduçãoRESUMO
When the products of a Strecker reaction of 1,2,3,4-tetrahydroisoquinolines with aromatic aldehydes are quaternized with alkyl triflates and subsequently treated with base, a ring expansion to 6,7,8,13-tetrahydro-5H-dibenzo[c,f]azonine-5-carbonitriles takes place. The nine-membered cyclic products can be obtained in good yields (78-89%) in a process involving the [1,4]-sigmatropic rearrangement of a nitrile-stabilized ammonium ylide. The reaction sequence provides a new, simple, and efficient method for the synthesis of these unusual N-heterocycles.
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Trypanosoma cruzi hosts can serve as a source of infection for animals, vectors, and humans, contributing to the establishment of Chagas disease (CD) in a given area. Traditionally, the Department of Córdoba has not been considered a transmission area for CD; however, the report of several acute cases of Chagas disease highlights the importance of studying the dynamics of disease transmission in this region. This study aimed to detect T. cruzi in domestic and wild mammals in the department of Córdoba. In 2017, a cross-sectional descriptive study was conducted in six villages in two municipalities in the department of Córdoba. Blood samples from dogs living in the zones were collected in EDTA vacutainer tubes for domestic mammals. Wild mammals were collected using Sherman and Tomahawk traps and mist nets in crops and peridomiciles. T. cruzi DNA was detected using the kinetoplast DNA (kDNA) variable region and the tandem repeat satellite region of T. cruzi as molecular targets. We sampled 168 dogs and 146 wild mammals. The detected prevalence of T. cruzi was 6.37%; the TcI lineage was found in D. marsupialis, H. anomalus, and one canine. A specimen of D. marsupialis with TcI and TcII lineages was also identified. T. cruzi DNA was detected in domestic and wild animals in the study area, indicating the circulation of the parasite in peridomestic environments. D. marsupialis may represent an important host in maintaining this region's wild and domestic cycle.
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Global changes have increased the risk of emerging infectious diseases, which can be prevented or mitigated by studying host-parasite interactions, among other measures. Bats and their ectoparasitic flies of the families Streblidae and Nycteribiidae are an excellent study model but, so far, our knowledge has been restricted to fragmented records at a local scale. To help boost research, we assembled a data set of bat-fly interactions from 174 studies published between 1904 and 2022 plus three original data sets. Altogether, these studies were carried out at 650 sites in the Neotropics, mainly distributed in Mexico, Brazil, Argentina, southern USA, and Colombia, among other countries. In total, our data set contains 3984 interaction records between 237 bat species and 255 fly species. The bat species with the largest number of recorded interactions were Carollia perspicillata (357), Artibeus jamaicensis (263), and Artibeus lituratus (228). The fly species with the largest number of recorded interactions were Trichobius joblingi (256), Megistopoda aranea (235), and Megistopoda proxima (215). The interaction data were extracted, filtered, taxonomically harmonized, and made available in a tidy format together with linked data on bat population, fly population, study reference, sampling methods and geographic information from the study sites. This interconnected structure enables the expansion of information for each interaction record, encompassing where and how each interaction occurred, as well as the number of bats and flies involved. We expect BatFly to open new avenues for research focused on different levels of ecological organization and spatial scales. It will help consolidate knowledge about ecological specialization, resource distribution, pathogen transmission, and the drivers of parasite prevalence over a broad spatial range. It may also help to answer key questions such as: Are there differences in fly prevalence or mean infestation across Neotropical ecoregions? What ecological drivers explain those differences? How do specialization patterns vary among fly species in the Neotropics? Furthermore, we expect BatFly to inspire research aimed at understanding how climate and land-use changes may impact host-parasite interactions and disease outbreaks. This kind of research may help us reach Sustainable Development Goal 3, Good Health and Wellbeing, outlined by the United Nations. The data are released under a Creative Commons Attribution 4.0 International License.
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Quirópteros , Dípteros , Parasitos , Animais , Brasil/epidemiologia , Interações Hospedeiro-ParasitaRESUMO
The Stevens rearrangement of nitrile-stabilized ammonium ylides in conjunction with the reductive removal of the nitrile function permits the facile construction of α-branched amines from α-aminonitriles. We employed this reaction sequence for the preparation of (±)-laudanosine, (±)-laudanidine and (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine from two closely related and readily accessible bicyclic α-aminonitriles. The final products were obtained in high to almost quantitative yields (71-98%) from the quaternary ammonium salts obtained by N-alkylation of these starting materials.
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Benzilisoquinolinas/síntese química , Alcaloides de Berberina/síntese química , Isoquinolinas/síntese química , Nitrilas/química , Compostos de Amônio Quaternário/síntese química , Quinolizinas/síntese química , Benzilisoquinolinas/química , Alcaloides de Berberina/química , Isoquinolinas/química , Estrutura Molecular , Compostos de Amônio Quaternário/química , Quinolizinas/química , EstereoisomerismoRESUMO
This study investigated whether sedentary behaviour modulates skeletal-muscle repair and tissue inflammatory response after cardiotoxin (CTX)-induced injury. Singly caged rats spent 8 weeks either as a sedentary group (SED, n = 15) or as a control group (EX, n = 15)caged with running wheels for voluntary running. All rats had each tibial anterior muscle infused either with CTX (CTX; right muscle) or saline solution (Sham; left muscle) and were sacrificed (n = 5 per group) on the 1st, 7th, and 15th day post-injection (dpi). Histological and immunohistochemical analyses were used to calculate myotube percentage and fibrosis accretion, and quantify the number of neutrophils and M1 and M2 macrophage subtypes. The SED group showed an increased number of both neutrophils and M1 macrophages (7th and 15th dpi) compared to the EX group (p < 0.01). The EX group showed an increased number of M2 macrophages on the 1st dpi. On the 7th dpi, the SED group showed a lower myotube percentage compared to the EX group (p < 0.01) and on the 15th dpi showed only 54% of normal undamaged fibres compared to 90% from the EX group (p < 0.01). The SED group showed increased fibrosis on both the 7th and 15th dpi. Our results show that sedentary behaviour affects the inflammatory response, enhancing and prolonging the Th1 phase, and delays and impairs the SMR process.
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The integration of the circular economy in agriculture has promoted sustainable innovation in food production systems such as horticulture. The present paper illustrates how horticulture is transitioning to the circular economy. This research field's performance approaches and trends were assessed through a bibliometric and text-mining analysis of the literature. Our findings revealed that circular horticulture is a recent research field that is constantly growing. Its approach has been neither systemic nor integrative but fragmented. Bioeconomy, urban agriculture, recycled nutrients, biochar, fertigation, and desalination have been positioned as research hotspots. Vegetables and fruits are the most studied crops. Resource circulation has focused primarily on biowaste recovery to provide benefits such as biofertilizers and linear-substrate substitutes, and on water reuse for the establishment of hydroponic systems. The One Health approach is scarcely explored and, therefore, weakly articulated, wherein the absence of assessment methodologies encompassing the health of ecosystems, animals, and people is a notable limitation. Science-policy interfaces between One Health and food systems need to be improved. Lastly, greenhouse technologies are aligned with bioenergy, sustainable materials, and sensing technologies. Challenges and directions for future research have been raised to promote the redesign of horticultural production systems, integrating long-term circularity.
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Ecossistema , Saúde Única , Agricultura/métodos , Animais , Horticultura , ÁguaRESUMO
The aim of the study was to assess the feasibility and reliability of physical fitness field tests used in the "Fuprecol kids" study among Colombian preschool children aged 3-5 years. A total of 90 preschoolers aged 3-5 years participated in the study. Weight, height, waist circumference, cardiorespiratory fitness (CRF), musculoskeletal fitness (handgrip strength and standing broad jump), speed-agility (4 × 10 m shuttle run), and flexibility (sit and reach test) components were tested twice (two weeks apart). The feasibility of the tests (preschoolers able to complete the test) ranged from 96% in the CRF test to 100% in the musculoskeletal fitness, speed-agility, and flexibility tests. Overall, the %TEMs were 0.625% for the weight, 0.378% for the height, 1.035% for the body mass index, and 0.547 % for the waist circumference. In addition, all tests were substantial reliable, for CRF (in stages and laps, concordance correlation coefficient = 0.944 and 0.941, respectively) in both sexes and flexibility (concordance correlation coefficient = 0.949) in girls. There were no significant differences in fitness test-retest mean differences in the boys (P > 0.05), except in CRF (laps P = 0.017). In girls, there were differences in CRF (stages (P = 0.017) and laps (P= 0.013)), and flexibility (P = 0.002) variables. The results from this study indicate that the "Fuprecol kids" battery of tests, administered by physical education teachers, was reliable and feasible for measuring components of physical fitness in preschoolers in a school setting in Colombia.
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Teste de Esforço , Aptidão Física/fisiologia , Índice de Massa Corporal , Pré-Escolar , Colômbia/epidemiologia , Estudos de Viabilidade , Feminino , Indicadores Básicos de Saúde , Humanos , Masculino , Reprodutibilidade dos TestesRESUMO
Data regarding the prevalence of metabolic syndrome (MTS) in Andean populations are limited. We evaluated the prevalence of MTS according to American Heart Association/National Heart, Lung and Blood Institute criteria among 1878 subjects in the PREVENCION study in Peru. In women, the most common component was low HDL cholesterol (60.9%) followed by abdominal obesity (36.9%). In men, the most common component was elevated triglycerides (52.0%) followed by low HDL cholesterol (32.5%), whereas the prevalence of abdominal obesity was 14%. Abnormal fasting glucose was the least common component in men (5.4%) and women (5.0%). The prevalence of MTS was significantly higher in women compared to men (23.2% versus 14.3%) and increased steeply with age, particularly in women (p<0.0001). Using body mass index (BMI>or=30kg/m2) instead of waist circumference as a component of the MTS lead to equivalent prevalence estimates of MTS in men but significantly underestimated the prevalence in women. The MTS is highly prevalent among Peruvian Andeans, particularly in older women. The pattern of MTS components in this Andean population is characterized by a high prevalence of dyslipidemia and a relatively low prevalence of elevated fasting glucose. Further studies are required to characterize genetic and environmental determinants of these patterns.
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Síndrome Metabólica/epidemiologia , Adulto , Idoso , Índice de Massa Corporal , HDL-Colesterol/sangue , Estudos Transversais , Feminino , Humanos , Indígenas Sul-Americanos/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Peru/epidemiologia , Prevalência , População Branca/estatística & dados numéricosRESUMO
Dysfunction affecting cardiac or pulmonary systems has been postulated as a major factor in sudden death in epilepsy (SUDEP). Whilst the majority of studies of cardiorespiratory function have focused on changes during seizures, here we investigate whether epilepsy influences basal respiratory parameters in patients with temporal lobe epilepsy (TLE) during the interictal period. Spirometry was performed in 10 females and 10 males. Measurements of Vital Capacity (VC), Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1) and ratios of FEV1 to FVC (FEV1/FVC) were obtained, and these values were analyzed as percentages of predicted values. None of the patients had chronic obstructive pulmonary disease and no significant alterations in respiratory function tests were found among these patients. No association between seizure frequency, antiepileptic drugs and SUDEP could be found in this study. Although the study did not identify any specific respiratory abnormality in TLE patients during the interictal period, re-evaluation of clinical data on pulmonary disorders in people with epilepsy should be better investigated.
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Epilepsia do Lobo Temporal/fisiopatologia , Volume Expiratório Forçado/fisiologia , Mecânica Respiratória/fisiologia , Capacidade Vital/fisiologia , Adulto , Feminino , Humanos , Masculino , EspirometriaRESUMO
Chagas disease (CD) is a systemic parasitic infection caused by the flagellated form of Trypanosoma cruzi. Córdoba department, located in the Colombian Caribbean Coast, was not considered as a region at risk of T. cruzi transmission. In this article, we describe the first acute CD case in Salitral village in Sahagún, Córdoba, confirmed by microscopy and serological tests. Our results draw attention to a new scenario of transmission of acute CD in nonendemic areas of Colombia and highlight the need to include CD in the differential diagnosis of febrile syndromes in this region.
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Latin America is undergoing the epidemiologic transition that occurred earlier in developed countries, and is likely to face a gigantic epidemic of heart disease in the next few years unless urgent action is taken. The first essential component of any effective cardiovascular disease (CVD) control program is to establish reliable estimates of cardiovascular disease-related morbidity and mortality. However, such data from population-based studies in Latin America are still lacking. In this paper, we present the design and operation of PREVENCION (Estudio Peruano de Prevalencia de Enfermedades Cardiovasculares, for Peruvian Study of the Prevalence of Cardiovascular diseases). PREVENCION is an ongoing population-based study on a representative sample of the civilian non-institutionalized population of the second largest city in Peru. Its population is comparable to the rest of the Peruvian urban population and closely resembles other Latin American populations in countries such as Bolivia and Ecuador. Our study will contribute to the enormous task of understanding and preventing CVD in Latin America.
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Doenças Cardiovasculares/prevenção & controle , Ensaios Clínicos como Assunto/métodos , Vigilância da População , Doenças Cardiovasculares/epidemiologia , Humanos , Incidência , Peru/epidemiologiaRESUMO
Las lesiones digitales distales han fomentado un gran debate referente a su tratamiento, que puede ser: quirúrgico o conservador. El tratamiento, en definitiva, siempre se encamina a lograr cubrir los tejidos expuestos y epitelizar el pulpejo del dedo afectado. Durante muchas décadas, ha existido la evidencia de que la cicatrización secundaria puede ser beneficiosa y logra resultados favorables; sin embargo, por diferentes motivos ha quedado rezagada frente a la opción quirúrgica. Presentamos el caso de un paciente con amputación traumática del extremo distal del 3er dedo de la mano derecha, que fue tratado de forma conservadora, y se logró buenos resultados estéticos y funcionales. Revisamos en la literatura la validez y equivalencia entre el resultado conservador y el quirúrgico
Distal digital injuries have presented a great debate regarding its treatment, it could be: Surgical and conservative. The treatment is always aimed at achieving coverage of exposed tissues and epithelialization of the affected finger pulp. There has been evidence for many decades that secondary healing can be beneficial for the patient with favorable results, however, due to different aspects, it has lagged behind the surgical option. We present a case of a patient with traumatic amputation of the distal end of the 3rd finger of the right hand, which was treated conservatively, finding good aesthetic and functional results over time. We review in the literature the validity and equivalence in the conservative and surgical result.Keywords: digital amputation, hand, pulp injury, conservative treatment, secondary scarring.
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Humanos , Masculino , Adulto , Dedos , Mãos , Amputação Traumática , Terapêutica , Ferimentos e Lesões , Tratamento ConservadorRESUMO
El quiste óseo aneurismático es una lesión ósea benigna que se presenta a edad temprana; su comportamiento suele ser agresivo por lo cual, la resección quirúrgica y la prevención de su recidiva son los pilares fundamentales de el tratamiento. Presentamos el caso de una paciente de 6 años de edad residente en Gualaceo, Ecuador, con masa de crecimiento progresivo y deformante en el codo izquierdo. Por las características de los exámenes de imagen y el cuadro sintomático se dignostica quiste óseo aneurismático que fue tratado con cirugía de resección intralesional y terapia adyuvante (fresado de alta velocidad, coagulación térmica y crioterapia). Se confirmó el diagnostico mediante el estudio histopatológico posquirúrgico
The aneurysmal bone cyst is a benign osseous lesion of presentation at an early age whose behavior is usually aggressive, so its surgical resection and the prevention of its recurrence is the fundamental pillar for the treatment. We present the case of a girl of 6 years of age living in Gualaceo, Ecuador, with a mass of progressive and deforming growth in the left elbow. By characteristics in the imaging tests and clinical picture it was considered as an aneurysmal bone cyst which was treated with intralesional resection surgery and adjuvant therapy (high speed burr, thermal coagulation and cryotherapy). The diagnosis was confirmed with postoperative histopathological study
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Humanos , Feminino , Criança , Cistos Ósseos , Crioterapia , Cistos Ósseos Aneurismáticos , Fotocoagulação , OrtopediaRESUMO
El género Carollia es un grupo diverso de murciélagos neotropicales. La similitud de caracteres morfométricos y alto grado de diversidad, dificulta la identificación precisa de las especies del género. Pese a ser un género común en Colombia, no existen reportes citogenéticos para la región Caribe, por tanto, se caracterizó su cariotipo y morfometría craneal, aportando datos citogenéticos útiles para dilucidar la taxonomía del género. Se realizaron muestreos en fragmentos de bosque y reservas de la sociedad civil del departamento de Córdoba. Se capturaron 15 individuos (6 machos, 9 hembras) obteniendo valores promedios de antebrazo de 41.92 mm, tibia de 18.49 mm y peso de 16.80 g, además de los valores obtenidos para las medidas craneales, dentales y mandibulares que confirman que el material fue correctamente catalogado como C. perspicillata. Cinco ejemplares fueron cariotipados (3 machos, 2 hembras), contabilizando 262 metafases. El número diploide de C. perspicillata se determinó de 2n = 20/XX para hembras y 2n = 21XY1Y2 para machos con Número Fundamental = 36. Por bandeo G se encontró homogeneidad en los pares 1, 2, 3 y 5. Con este trabajo, se incrementa la representatividad geográfica de los estudios citogenéticos de C. perspicillata para la costa norte de Colombia, conservando normalidad en cuanto al número cromosómico reportado.
The Carollia genus is a diverse group of bats from the Neotropical region, the similarity of its morphometric characters and high level diversity make it difficult to pinpoint the exact identification of species from this genus along its distribution. However, despite the Carollia being common for Colombia, there does not exist some cytogenetic research for Colombian Caribbean region, therefore, it characterized its karyotype and cranial morphometry, providing useful data that can contribute to taxonomic identification of the genus. The specimens of C. perspicillata samples were collected in forest fragments and civil society reserves in the Córdoba department, Colombia. Captured 15 individuals (6 males and 9 females) obtaining average forearm values of 41.92 mm, tibia 18.49 mm and weight 16.80 g, in addition to the values obtained for the cranial, dental and mandibular measurements that confirm that the material was catalogued correctly as C. perspicillata. Five specimens were used for the karyotype analysis (3 males, 2 females), counting 262 metaphases. The diploid number of C. perspicillata was determined from 2n = 20/XX for females and 2n = 21XY1Y2 for males with Fundamental Number = 36. By band G, homogeneity was found in pairs 1, 2, 3 and 5. This research increases the geographic representativeness of the cytogenetic studies of C. perspicillata for the northern of Colombia, preserving normality in terms of the chromosomal number reported.