Detalhe da pesquisa
1.
Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Kidney Int
; 104(4): 724-739, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399974
2.
Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease.
Molecules
; 27(11)2022 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684355
3.
Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle.
Mol Pharmacol
; 99(2): 114-124, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33268552
4.
Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model.
Bioorg Med Chem
; 27(19): 115014, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358358
5.
Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents.
Bioorg Med Chem Lett
; 28(3): 529-532, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29295794
6.
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 27(16): 3909-3914, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28666737
7.
Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis.
Nat Commun
; 15(1): 645, 2024 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38245505
8.
Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation.
Cell Mol Gastroenterol Hepatol
; 15(2): 439-461, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36229019
9.
Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease.
Eur J Med Chem
; 239: 114517, 2022 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732081
10.
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
J Med Chem
; 64(2): 1037-1053, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417443
11.
TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation.
Nat Commun
; 11(1): 4012, 2020 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32782388
12.
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease.
J Med Chem
; 63(8): 4171-4182, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285676
13.
Dopamine neuron induction and the neuroprotective effects of thyroid hormone derivatives.
Sci Rep
; 9(1): 13659, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31541140
14.
Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
J Med Chem
; 62(2): 575-588, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30623649
15.
Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.
Eur J Med Chem
; 101: 716-35, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218650
16.
Correction to Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
J Med Chem
; 62(5): 2849, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30811938