Detalhe da pesquisa
1.
A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism.
J Biol Chem
; 294(19): 7658-7668, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30923129
2.
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
J Pharmacol Exp Ther
; 361(2): 229-244, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193636
3.
Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aß42 lowering in rodents and rhesus monkeys.
Bioorg Med Chem Lett
; 25(17): 3488-94, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26212776
4.
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
J Biol Chem
; 286(8): 6433-48, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21118801
5.
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity.
Emerg Microbes Infect
; 11(1): 914-925, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35254215
6.
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
J Med Chem
; 65(7): 5675-5689, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332774
7.
STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors.
Mol Cancer Ther
; 21(2): 282-293, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34815361
8.
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
Am J Pathol
; 177(1): 415-23, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20489150
9.
An orally available non-nucleotide STING agonist with antitumor activity.
Science
; 369(6506)2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32820094
10.
Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival.
Cancer Res
; 67(5): 2081-8, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332337
11.
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ACS Med Chem Lett
; 10(1): 92-97, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655953
12.
High-throughput analysis of HGF-stimulated cell scattering.
J Biomol Screen
; 13(9): 847-54, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18812567
13.
Analysis of the activating mutations within the activation loop of leukemia targets Flt-3 and c-Kit based on protein homology modeling.
J Mol Graph Model
; 23(2): 153-65, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15363457
14.
FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.
PLoS One
; 9(6): e98515, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24968263
15.
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J Med Chem
; 56(6): 2294-310, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23379595
16.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
J Med Chem
; 54(12): 4092-108, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21608528
17.
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo.
Mol Cancer Ther
; 9(7): 1956-67, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20571069
18.
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Cancer Res
; 70(4): 1524-33, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20145145