Sepsis: Updated definitions and optimized management. / Sepsis: Diagnostik und Therapie im Wandel Aktuelle Strategien gegen eine lebensbedrohliche Erkrankung.

Sepsis is newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunction will be determined by an increase in the Sepsis-related Organ Failure Assessment (SOFA) score. The updated definition should facilitate earlier recognition and more timely management of patients with sepsis. Sepsis should be treated as quickly and efficiently as possible as soon as it has been identified. This implies rapid administration of antibiotics and fluids.

[Multidrug-resistant bacteria require new treatment options]. / Multiresistente Erreger erfordern neue Konzepte. Infektionsprävention in der Onkologie.

By now multidrug-resistant bacteria are a common cause of infections, especially in immunocompromised patient. These infections have to be treated with last resort antibiotics, such as colistin for the treatment of drug-resistant enterobacteriaceae or acinetobacter spp. Additionally the prevention of infections plays an important role in protecting critically ill patients.