Detalhe da pesquisa
1.
Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.
Bioorg Med Chem Lett
; 74: 128927, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35944849
2.
Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors.
Bioorg Med Chem Lett
; 44: 128082, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991626
3.
Identification of second-generation P2X3 antagonists for treatment of pain.
Bioorg Med Chem Lett
; 28(8): 1392-1396, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29548573
4.
Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.
Bioorg Med Chem Lett
; 25(21): 4777-4781, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231160
5.
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.
bioRxiv
; 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496440
6.
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
Bioorg Med Chem Lett
; 21(9): 2683-6, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21251825
7.
Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.
Bioorg Med Chem Lett
; 21(8): 2359-64, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21420857
8.
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
J Pharmacol Exp Ther
; 324(2): 416-21, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039958
9.
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
Org Lett
; 10(15): 3235-8, 2008 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18590336
10.
Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.
Bioorg Med Chem Lett
; 18(2): 755-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039571
11.
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ACS Med Chem Lett
; 9(8): 815-820, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128073
12.
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
J Med Chem
; 50(23): 5564-7, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17929795
13.
Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review.
Expert Opin Ther Pat
; 19(12): 1675-713, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19939188
14.
Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.
Org Lett
; 11(2): 345-7, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19093828
15.
Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.
Eur J Pharmacol
; 602(2-3): 250-4, 2009 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19084002
16.
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.
Bioorg Med Chem Lett
; 17(17): 4795-8, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17616394