Detalhe da pesquisa
1.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
2.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
3.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
4.
Structure-activity relationship studies of antiplasmodial aminomethylthiazoles.
Bioorg Med Chem Lett
; 24(22): 5207-11, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316314
5.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
6.
Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.
Malar J
; 12: 424, 2013 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24237770
7.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
8.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
9.
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.
Medchemcomm
; 10(12): 2118-2125, 2019 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32206243
10.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
11.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
12.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
13.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446690
14.
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model".
J Med Chem
; 64(3): 1762, 2021 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508187
15.
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
J Med Chem
; 59(21): 9890-9905, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748596
16.
Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.
J Med Chem
; 58(18): 7572-9, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26322748
17.
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
J Med Chem
; 58(21): 8713-22, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502160
18.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
J Med Chem
; 57(21): 8839-48, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313449
19.
2,4-Diaminothienopyrimidines as orally active antimalarial agents.
J Med Chem
; 57(3): 1014-22, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446664
20.
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
J Med Chem
; 56(21): 8860-71, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099149