Detalhe da pesquisa
1.
Gαs is dispensable for ß-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by ß2-adrenergic receptor.
J Biol Chem
; 299(11): 105293, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774973
2.
Receptor sequestration in response to ß-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.
Proc Natl Acad Sci U S A
; 112(37): E5160-8, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324936
3.
Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease.
Cells
; 12(7)2023 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37048075
4.
Computationally designed GPCR quaternary structures bias signaling pathway activation.
Nat Commun
; 13(1): 6826, 2022 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369272
5.
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Clin Cancer Res
; 27(11): 3190-3200, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33568347
6.
The RanBP2/RanGAP1-SUMO complex gates ß-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.
Oncogene
; 40(12): 2243-2257, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649538
7.
A new inhibitor of the ß-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.
Nat Commun
; 8: 15054, 2017 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416805
8.
Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Clin Cancer Res
; 27(16): 4664, 2021 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34389658
9.
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Nat Commun
; 5: 4431, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25028204