Detalhe da pesquisa
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37362320
2.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35605346
3.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508465
4.
Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors.
Bioorg Med Chem Lett
; 30(21): 127516, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860982
5.
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Bioorg Med Chem Lett
; 28(12): 2124-2130, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779976
6.
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorg Med Chem Lett
; 28(9): 1550-1557, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631960
7.
Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Bioorg Med Chem Lett
; 26(1): 160-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584882
8.
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Bioorg Med Chem Lett
; 26(3): 936-940, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26747393
9.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988305
10.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26968652
11.
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 25(3): 717-20, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25529736
12.
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
Bioorg Med Chem Lett
; 23(1): 218-22, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23206859
13.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorg Med Chem Lett
; 23(1): 213-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200254
14.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem
; 66(3): 1941-1954, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719971
15.
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
J Med Chem
; 65(6): 4949-4971, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35235334
16.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett
; 13(6): 972-980, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707159
17.
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
J Med Chem
; 62(3): 1348-1361, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609350
18.
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir.
J Med Chem
; 61(14): 6308-6327, 2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29920093
19.
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
J Med Chem
; 61(16): 7289-7313, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30067361
20.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
ACS Med Chem Lett
; 7(6): 568-72, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326328