Detalhe da pesquisa
1.
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.
Nat Chem Biol
; 13(5): 486-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28244987
2.
Clinical activity of carfilzomib correlates with inhibition of multiple proteasome subunits: application of a novel pharmacodynamic assay.
Br J Haematol
; 173(6): 884-95, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27071340
3.
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity.
J Med Chem
; 66(1): 345-370, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36529947
4.
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.
Blood
; 114(16): 3439-47, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19671918
5.
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.
PLoS One
; 16(11): e0259241, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34731180
6.
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion.
J Cell Biol
; 164(1): 79-88, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14699088
7.
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.
Cancer Res
; 67(13): 6383-91, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17616698
8.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
Cancer Res
; 79(13): 3251-3267, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31040157
9.
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
Cancer Cell
; 33(5): 905-921.e5, 2018 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29763624
10.
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
J Med Chem
; 60(4): 1343-1361, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28191850
11.
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment.
J Immunother Cancer
; 5(1): 101, 2017 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254508
12.
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Cell Rep
; 18(3): 601-610, 2017 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28099841
13.
Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).
J Med Chem
; 58(24): 9480-97, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26565666
14.
Drug discovery in the ubiquitin regulatory pathway.
Drug Discov Today
; 8(16): 746-54, 2003 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12944097
15.
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.
Mol Cancer Ther
; 13(4): 890-901, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24523301
16.
Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
J Med Chem
; 60(7): 3217, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28328205
17.
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events.
Clin Cancer Res
; 17(9): 2734-43, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21364033
18.
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.
Nat Med
; 15(7): 781-7, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19525961
19.
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).
J Med Chem
; 52(9): 3028-38, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19348473
20.
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity.
Proc Natl Acad Sci U S A
; 99(8): 5424-9, 2002 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-11959998